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2.7.7.14: ethanolamine-phosphate cytidylyltransferase

This is an abbreviated version!
For detailed information about ethanolamine-phosphate cytidylyltransferase, go to the full flat file.

Word Map on EC 2.7.7.14

Reaction

CTP
+
Ethanolamine phosphate
=
diphosphate
+
CDP-ethanolamine

Synonyms

CTP-phosphoethanolamine cytidylyltransferase, CTP:ethanolaminephosphate cytidylyltransferase, CTP:phosphoethanolamine CT, CTP:phosphoethanolamine cytidylyltransferase, CTP:phosphoethanolamine cytidylyltransferase gene, cytidylyltransferase, ethanolamine phosphate, ECT, ET, ethanolamine phosphate cytidylyltransferase, ethanolamine-phosphate cytidylyltransferase, Pcyt2, Pcyt2alpha, Pcyt2beta, PECT1, phosphoethanolamine cytidyltransferase, phosphoethanolamine cytidylyltransferase, phosphorylethanolamine transferase, Tb11.01.5730

ECTree

     2 Transferases
         2.7 Transferring phosphorus-containing groups
             2.7.7 Nucleotidyltransferases
                2.7.7.14 ethanolamine-phosphate cytidylyltransferase

Engineering

Engineering on EC 2.7.7.14 - ethanolamine-phosphate cytidylyltransferase

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PROTEIN VARIANTS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
H226A
mutation in histidine residue in the HxGH motif of the C-terminal CT domain. Decrease in activity
H229A
mutation in histidine residue in the HxGH motif of the N-terminal CT domain. Activity similar to wild-type activity
H35A
mutation in histidine residue in the HxGH motif of the N-terminal CT domain. Complete loss of activity
H38A
mutation in histidine residue in the HxGH motif of the N-terminal CT domain. Strong decrease in activity
H244A
inactive C-domain mutant, presence of the mutant reduces splice variant Pcyt2alpha homodimerization and activity
H244Y
inactive C-domain mutant, presence of the mutant reduces splice variant Pcyt2alpha homodimerization and activity
H35A
inactive N-domain mutant, presence of the mutant reduces splice variant Pcyt2alpha homodimerization and activity
H35Y
inactive N-domain mutant, presence of the mutant reduces splice variant Pcyt2alpha homodimerization and activity
H146A
site-directed mutagenesis, the mutant is almost inactive
H422A
site-directed mutagenesis, the mutant shows increased kcat and Vmax with ethanolamine phosphate compared to the wild-type enzyme