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2.7.7.15: choline-phosphate cytidylyltransferase

This is an abbreviated version!
For detailed information about choline-phosphate cytidylyltransferase, go to the full flat file.

Word Map on EC 2.7.7.15

Reaction

CTP
+
phosphocholine
=
diphosphate
+
CDP-choline

Synonyms

AtCCT1, CCT, CCT-alpha, CCT1, CCT2, CCTalpha, CCTalpha236, CCTbeta, CCTbeta2, CCTbeta3, CDP-choline pyrophosphorylase, CDP-choline synthetase, choline phosphate cytidylyltransferase, choline-phosphate cytidylyltransferase A, choline-phosphate cytidylyltransferase-alpha, cholinephosphate cytidylyltransferase, CpCCT1, cpcT, CTalpha, CTbeta2, CTP-phosphocholine cytidylyltransferase, CTP:cholinephosphate cytidylyltransferase, CTP:phosphocholine cytidylyltransferase, CTP:phosphocholine cytidylyltransferase alpha, CTP:phosphocholine cytidylyltransferase alpha-isoform, CTP:phosphocholine cytidylyltransferase beta2, CTP:phosphocholine cytidylyltransferase beta3, CTP:phosphocholine cytidylyltransferase CCT, CTP:phosphocholine cytidylyltransferase-alpha, CTP:phosphocholine cytidylyltransferase-beta2, CTP:phosphocholine cytidylyltranspherase alpha, CTP:phosphorylcholine cytidylyltransferase, CTP:phosphorylcholine cytidylyltransferase CCT1, CTP:phosphorylcholine cytidylyltransferase CCT2, cytidine diphosphocholine pyrophosphorylase, cytidylyltransferase, cytidylyltransferase, choline phosphate, LmjF.18.1330, More, PCYT1A, PF3D7_1316600, PfCCT, phosphocholine cytidylyltransferase, phosphocholine cytidylyltransferase alpha, phosphorylcholine cytidylyltransferase, phosphorylcholine transferase, phosphorylcholine:CTP cytidylyltransferase

ECTree

     2 Transferases
         2.7 Transferring phosphorus-containing groups
             2.7.7 Nucleotidyltransferases
                2.7.7.15 choline-phosphate cytidylyltransferase

Disease

Disease on EC 2.7.7.15 - choline-phosphate cytidylyltransferase

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DISEASE
TITLE OF PUBLICATION
LINK TO PUBMED
Acidosis
Effects of hypoxia, glucose deprivation and acidosis on phosphatidylcholine synthesis in HL-1 cardiomyocytes. CTP:phosphocholine cytidylyltransferase activity correlates with sarcolemmal disruption.
Adenocarcinoma
Phosphatidylcholine synthesis regulates triglyceride storage and chylomicron secretion by Caco2 cells.
Adenocarcinoma of Lung
PCYT1A suppresses proliferation and migration via inhibiting mTORC1 pathway in lung adenocarcinoma.
Brain Diseases
Kinetic and biochemical properties of CTP:choline-phosphate cytidylyltransferase from the rat brain.
Brain Ischemia
CDP-choline significantly restores phosphatidylcholine levels by differentially affecting phospholipase A2 and CTP: phosphocholine cytidylyltransferase after stroke.
Cytidine-5'-diphosphocholine affects CTP-phosphocholine cytidylyltransferase and lyso-phosphatidylcholine after transient brain ischemia.
Carcinoma
Increased expression of cytosolic chaperonin CCT in human hepatocellular and colonic carcinoma.
Carcinoma, Embryonal
Subunits of the eukaryotic cytosolic chaperonin CCT do not always behave as components of a uniform hetero-oligomeric particle.
Carcinoma, Hepatocellular
Expression of phosphatidylethanolamine N-methyltransferase in Yoshida ascites hepatoma cells and the livers of host rats.
Expression of phosphatidylethanolamine N-methyltransferase-2 in McArdle-RH7777 hepatoma cells inhibits the CDP-choline pathway for phosphatidylcholine biosynthesis via decreased gene expression of CTP:phosphocholine cytidylyltransferase.
Increased expression of cytosolic chaperonin CCT in human hepatocellular and colonic carcinoma.
Phosphatidylethanolamine methylation and hepatoma cell growth.
Phosphatidylethanolamine N-methyltransferase: unexpected findings from curiosity-driven research.
Cerebral Palsy
Morphometric analysis of acetabular dysplasia in cerebral palsy: three-dimensional CT study.
Choline Deficiency
Choline deficiency causes translocation of CTP:phosphocholine cytidylyltransferase from cytosol to endoplasmic reticulum in rat liver.
Effect of choline deficiency on CTP: phosphocholine cytidylyltransferase and choline kinase activities in rat liver subcellular fractions.
choline-phosphate cytidylyltransferase deficiency
Polyploid formation via chromosome duplication induced by CTP:phosphocholine cytidylyltransferase deficiency and Bcl-2 overexpression: identification of two novel endogenous factors.
Cone-Rod Dystrophies
Mutations in PCYT1A cause spondylometaphyseal dysplasia with cone-rod dystrophy.
Mutations in PCYT1A, encoding a key regulator of phosphatidylcholine metabolism, cause spondylometaphyseal dysplasia with cone-rod dystrophy.
Mutations in the PCYT1A gene are responsible for isolated forms of retinal dystrophy.
Novel mutations in PCYT1A are responsible for spondylometaphyseal dysplasia with cone-rod dystrophy.
Dehydration
Identification and characterization of CTP:phosphocholine cytidylyltransferase CpCCT1 in the resurrection plant Craterostigma plantagineum.
Endometriosis
Polymorphic variants of folate and choline metabolism genes and the risk of endometriosis-associated infertility.
Fatty Liver
Mutations disrupting the Kennedy phosphatidylcholine pathway in humans with congenital lipodystrophy and fatty liver disease.
Mutations in the PCYT1A gene are responsible for isolated forms of retinal dystrophy.
Fetal Death
Polymorphic variants of genes involved in choline pathway and the risk of intrauterine fetal death.
Gaucher Disease
Changes in macrophage morphology in a Gaucher disease model are dependent on CTP:phosphocholine cytidylyltransferase alpha.
Phosphatidylcholine synthesis is elevated in neuronal models of Gaucher disease due to direct activation of CTP:phosphocholine cytidylyltransferase by glucosylceramide.
Infections
c-Jun N-terminal kinase regulates CTP:phosphocholine cytidylyltransferase.
Chronic Pseudomonas aeruginosa infection reduces surfactant levels by inhibiting its biosynthesis.
Enteropathogenic Escherichia coli infection triggers host phospholipid metabolism perturbations.
Stimulated phospholipid synthesis is key for hepatitis B virus replications.
Insulin Resistance
Accelerated phosphatidylcholine turnover in macrophages promotes adipose tissue inflammation in obesity.
Lipodystrophy
Mutations in the PCYT1A gene are responsible for isolated forms of retinal dystrophy.
Liver Cirrhosis
Metabolomics combined with network pharmacology exploration reveals the modulatory properties of Astragali Radix extract in the treatment of liver fibrosis.
Liver Diseases
Mutations in the PCYT1A gene are responsible for isolated forms of retinal dystrophy.
Lung Injury
Adenoviral gene transfer of a mutant surfactant enzyme ameliorates pseudomonas-induced lung injury.
Nitric oxide-induced activation of NF-kappaB-mediated NMDA-induced CTP:phosphocholine cytidylyltransferase alpha expression inhibition in A549 cells.
Lung Neoplasms
PCYT1A suppresses proliferation and migration via inhibiting mTORC1 pathway in lung adenocarcinoma.
Lymphoma
MYC is a positive regulator of choline metabolism and impedes mitophagy-dependent necroptosis in diffuse large B-cell lymphoma.
Lymphoma, B-Cell
Polyploid formation via chromosome duplication induced by CTP:phosphocholine cytidylyltransferase deficiency and Bcl-2 overexpression: identification of two novel endogenous factors.
Metabolism, Inborn Errors
Choline-related-inherited metabolic diseases-A mini review.
Neoplasms
CTP:phosphocholine cytidylyltransferase inhibition by ceramide via PKC-alpha, p38 MAPK, cPLA2, and 5-lipoxygenase.
Differential targets and subcellular localization of antitumor alkyl-lysophospholipid in leukemic versus solid tumor cells.
Increased expression of cytosolic chaperonin CCT in human hepatocellular and colonic carcinoma.
MYC is a positive regulator of choline metabolism and impedes mitophagy-dependent necroptosis in diffuse large B-cell lymphoma.
PCYT1A suppresses proliferation and migration via inhibiting mTORC1 pathway in lung adenocarcinoma.
Pharmacological inhibition of phosphatidylcholine biosynthesis is associated with induction of phosphatidylinositol accumulation and cytolysis of neoplastic cell lines.
The modulation of choline phosphoglyceride metabolism in human colon cancer.
Tumor necrosis factor-alpha inhibits expression of CTP:phosphocholine cytidylyltransferase.
Neuroblastoma
Production of diacylglycerol by exogenous phospholipase C stimulates CTP:phosphocholine cytidylyltransferase activity and phosphatidylcholine synthesis in human neuroblastoma cells.
Pancreatic Neoplasms
Identification of prognostic lipid droplet-associated genes in pancreatic cancer patients via bioinformatics analysis.
Parkinson Disease
Elevated activity of phospholipid biosynthetic enzymes in substantia nigra of patients with Parkinson's disease.
Polycystic Ovary Syndrome
Methylome and transcriptome profiling revealed epigenetic silencing of LPCAT1 and PCYT1A associated with lipidome alterations in polycystic ovary syndrome.
Premature Birth
Evidence for a regulatory role of CTP : choline phosphate cytidylyltransferase in the synthesis of phosphatidylcholine in fetal lung following premature birth.
Quadriplegia
Morphometric analysis of acetabular dysplasia in cerebral palsy: three-dimensional CT study.
Respiratory Insufficiency
Role of phosphocholine cytidylyltransferase alpha in lung development.
Retinal Dystrophies
Mutations in the PCYT1A gene are responsible for isolated forms of retinal dystrophy.
Retinoblastoma
Sp-1 binds promoter elements that are regulated by retinoblastoma and regulate CTP:phosphocholine cytidylyltransferase-alpha transcription.
Sepsis
Adenoviral gene transfer of a mutant surfactant enzyme ameliorates pseudomonas-induced lung injury.
Spinal Dysraphism
CHKA and PCYT1A gene polymorphisms, choline intake and spina bifida risk in a California population.
Starvation
Alteration in the characters of CDP-choline synthetase and phospholipid-choline exchange enzyme upon choline starvation in Chinese hamster ovary cells.
Stroke
CDP-choline significantly restores phosphatidylcholine levels by differentially affecting phospholipase A2 and CTP: phosphocholine cytidylyltransferase after stroke.