2.7.7.15: choline-phosphate cytidylyltransferase
This is an abbreviated version!
For detailed information about choline-phosphate cytidylyltransferase, go to the full flat file.
Word Map on EC 2.7.7.15
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2.7.7.15
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phosphatidylcholine
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phospholipid
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phosphatidylethanolamine
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surfactant
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fetal
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diacylglycerol
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phospholipase
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ptdcho
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alveolar
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cholinephosphotransferase
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oleate
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phosphatidylglycerol
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amphipathic
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membrane-binding
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n-methyltransferase
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disaturated
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lysophosphatidylcholine
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phosphatidate
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3hcholine
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vance
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kennedy
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cytidyltransferase
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1,2-diacylglycerols
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phosphoethanolamine
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3hglycerol
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amphitropic
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l-forms
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methyl-14ccholine
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hexadecylphosphocholine
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analysis
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diagnostics
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choline-deficient
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cdpcholine
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methyl-3hcholine
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2.7.8.2
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14ccholine
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ctp:phosphoethanolamine
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choline-containing
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cdp-ethanolamine
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medicine
- 2.7.7.15
- phosphatidylcholine
- phospholipid
- phosphatidylethanolamine
- surfactant
- fetal
- diacylglycerol
- phospholipase
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ptdcho
- alveolar
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cholinephosphotransferase
- oleate
- phosphatidylglycerol
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amphipathic
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membrane-binding
- n-methyltransferase
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disaturated
- lysophosphatidylcholine
- phosphatidate
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3hcholine
-
vance
-
kennedy
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cytidyltransferase
- 1,2-diacylglycerols
- phosphoethanolamine
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3hglycerol
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amphitropic
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l-forms
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methyl-14ccholine
- hexadecylphosphocholine
- analysis
- diagnostics
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choline-deficient
- cdpcholine
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methyl-3hcholine
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2.7.8.2
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14ccholine
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ctp:phosphoethanolamine
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choline-containing
- cdp-ethanolamine
- medicine
Reaction
Synonyms
AtCCT1, CCT, CCT-alpha, CCT1, CCT2, CCTalpha, CCTalpha236, CCTbeta, CCTbeta2, CCTbeta3, CDP-choline pyrophosphorylase, CDP-choline synthetase, choline phosphate cytidylyltransferase, choline-phosphate cytidylyltransferase A, choline-phosphate cytidylyltransferase-alpha, cholinephosphate cytidylyltransferase, CpCCT1, cpcT, CTalpha, CTbeta2, CTP-phosphocholine cytidylyltransferase, CTP:cholinephosphate cytidylyltransferase, CTP:phosphocholine cytidylyltransferase, CTP:phosphocholine cytidylyltransferase alpha, CTP:phosphocholine cytidylyltransferase alpha-isoform, CTP:phosphocholine cytidylyltransferase beta2, CTP:phosphocholine cytidylyltransferase beta3, CTP:phosphocholine cytidylyltransferase CCT, CTP:phosphocholine cytidylyltransferase-alpha, CTP:phosphocholine cytidylyltransferase-beta2, CTP:phosphocholine cytidylyltranspherase alpha, CTP:phosphorylcholine cytidylyltransferase, CTP:phosphorylcholine cytidylyltransferase CCT1, CTP:phosphorylcholine cytidylyltransferase CCT2, cytidine diphosphocholine pyrophosphorylase, cytidylyltransferase, cytidylyltransferase, choline phosphate, LmjF.18.1330, More, PCYT1A, PF3D7_1316600, PfCCT, phosphocholine cytidylyltransferase, phosphocholine cytidylyltransferase alpha, phosphorylcholine cytidylyltransferase, phosphorylcholine transferase, phosphorylcholine:CTP cytidylyltransferase
ECTree
2.7.7.15 choline-phosphate cytidylyltransferaseAdvanced search results
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results (Localization
Localization on EC 2.7.7.15 - choline-phosphate cytidylyltransferase
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LOCALIZATION 
ORGANISM
UNIPROT
COMMENTARY 
GeneOntology No.
LITERATURE
SOURCE
nuclear membrane association of CCTa induced by oleate loading is linked to dephosphorylation of S319
additional information
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distributed between cytosol and membrane, lipid environment required for activity
activation of phosphatidylcholine biosynthesis by phospholipase C treatment induces the partial nuclear-to-cytoplasmic translocation of the enzyme
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642889, 642890, 642893, 642894, 642897, 642900, 642902, 642904, 642905, 642908, 642909, 642913, 642914, 642924, 660981
CCTbeta expression appears to be cytosolic within these Purkinje cells
mainly located in the endoplasmic reticulum
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CTP:phosphocholine cytidylyltransferase binds stably and via its amphipatic alpha helix to lipid droplet surface during surface expansion, which is essential for the lipid droplet. It is the only enzyme of the phosphatidylecholine synthesis Kennedy pathway that localizes in the lipid droplets
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CTP:phosphocholine cytidylyltransferase binds stably and via its amphipatic alpha helix to lipid droplet surface during surface expansion, which is essential for the lipid droplet. It is the only enzyme of the phosphatidylecholine synthesis Kennedy pathway that localizes in the lipid droplets
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distributed between cytosol and membrane, lipid environment required for activity
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enzyme is activated when bound to vesicles
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L-form binds to microsomal membrane, is formed in to H-form and H-form is released from membrane
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in CHO cells, CCTalpha is nucleoplasmic and colocalized with GFP-progerin in nuclear folds and invaginations
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reversibly translocates to nuclear tubules projecting from the nucleoplasmic reticulum in response to oleate
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lipid activation of the enzyme results in its translocation to the nuclear envelope and expansion of an intranuclear membrane network termed the nucleoplasmic reticulum by a mechanism involving membrane deformation
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CCT-alpha forms intranuclear foci that colocalise with invaginations in prelamin-A-accumulating cells, overview
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lipid activation of the enzyme results in its translocation to the nuclear envelope and expansion of an intranuclear membrane network termed the nucleoplasmic reticulum by a mechanism involving membrane deformation
Plasmodium-specific lysine-rich insertion within the catalytic domain of the enzyme acts as a nuclear localization signal and its deletion decreases the nuclear propensity of the protein in the model cell line. The putative membrane-binding domain also affected the nuclear localization of the protein. Activation of phosphatidylcholine biosynthesis by phospholipase C treatment induces the partial nuclear-to-cytoplasmic translocation of the enzyme
additional information
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immunohistochemic analysis of enzyme subcellular localization, overview
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additional information
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CCT1 Is mobile and shuttles between nucleus and cytosol before oleate loading. CCT1 targets to lipid droplets after an initial delay and relocalizes to the nucleus when oleate is removed. CCT1 is targeted to lipid droplets when phosphatidylcholine levels are inadequate
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additional information
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immunohistochemic analysis of enzyme subcellular localization, overview
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additional information
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CCT1 Is mobile and shuttles between nucleus and cytosol before oleate loading. CCT1 targets to lipid droplets after an initial delay and relocalizes to the nucleus when oleate is removed. CCT1 is targeted to lipid droplets when phosphatidylcholine levels are inadequate
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