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CTP + choline phosphate
diphosphate + CDP-choline
CTP + choline phosphate
diphosphate + CDPcholine
CTP + ethanolamine phosphate
diphosphate + CDPethanolamine
CTP + phosphocholine
diphosphate + CDP-choline
CTP + phosphodimethylethanolamine
diphosphate + CDPdimethylethanolamine
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?
CTP + phosphomonomethylethanolamine
diphosphate + CDPmethylethanolamine
additional information
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-
CTP + choline phosphate
diphosphate + CDP-choline
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?
CTP + choline phosphate
diphosphate + CDP-choline
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rate limiting enzyme for the synthesis of phosphatidylcholine, inhibition of CCT triggers apoptosis, involved in cold acclimation
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?
CTP + choline phosphate
diphosphate + CDP-choline
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CTP + choline phosphate
diphosphate + CDP-choline
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?
CTP + choline phosphate
diphosphate + CDP-choline
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-
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?
CTP + choline phosphate
diphosphate + CDP-choline
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rate limiting enzyme for the synthesis of phosphatidylcholine
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?
CTP + choline phosphate
diphosphate + CDP-choline
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?
CTP + choline phosphate
diphosphate + CDP-choline
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rate limiting enzyme for the synthesis of phosphatidylcholine, inhibition of CCT triggers apoptosis
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?
CTP + choline phosphate
diphosphate + CDP-choline
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-
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?
CTP + choline phosphate
diphosphate + CDP-choline
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rate limiting enzyme for the synthesis of phosphatidylcholine
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?
CTP + choline phosphate
diphosphate + CDP-choline
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-
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?
CTP + choline phosphate
diphosphate + CDP-choline
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-
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?
CTP + choline phosphate
diphosphate + CDP-choline
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rate limiting enzyme for the synthesis of phosphatidylcholine
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?
CTP + choline phosphate
diphosphate + CDP-choline
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rate limiting enzyme for the synthesis of phosphatidylcholine, inhibition of CCT triggers apoptosis, disruption of CCTbeta leads to gonadal dysfunction and reduced fertility
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?
CTP + choline phosphate
diphosphate + CDP-choline
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?
CTP + choline phosphate
diphosphate + CDP-choline
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-
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?
CTP + choline phosphate
diphosphate + CDP-choline
-
rate limiting enzyme for the synthesis of phosphatidylcholine
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?
CTP + choline phosphate
diphosphate + CDPcholine
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-
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?
CTP + choline phosphate
diphosphate + CDPcholine
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?
CTP + choline phosphate
diphosphate + CDPcholine
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-
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?
CTP + choline phosphate
diphosphate + CDPcholine
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?
CTP + choline phosphate
diphosphate + CDPcholine
-
rate limiting step in synthesis of phosphatidylcholine
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?
CTP + choline phosphate
diphosphate + CDPcholine
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dCTP can replace CTP with reduced activity
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?
CTP + choline phosphate
diphosphate + CDPcholine
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?
CTP + choline phosphate
diphosphate + CDPcholine
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?
CTP + choline phosphate
diphosphate + CDPcholine
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?
CTP + choline phosphate
diphosphate + CDPcholine
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-
642894, 642895, 642896, 642898, 642900, 642902, 642903, 642904, 642905, 642906, 642907, 642908, 642909, 642913, 642914, 642915, 642916, 642919, 642921, 642923, 642924, 642926, 642928 -
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CTP + choline phosphate
diphosphate + CDPcholine
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highly specific for phosphocholine
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r
CTP + choline phosphate
diphosphate + CDPcholine
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beta2 isoform specifically up-regulated during neuronal differentiation to increase phosphatidyl choline biosynthesis for growing neuritis
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?
CTP + choline phosphate
diphosphate + CDPcholine
-
rate limiting step in synthesis of phosphatidylcholine
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?
CTP + choline phosphate
diphosphate + CDPcholine
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membrane binding segment has important role in cellular lipid metabolism
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?
CTP + choline phosphate
diphosphate + CDPcholine
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catalyzes a major rate-limiting step in the biosynthesis of phosphocholine
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?
CTP + choline phosphate
diphosphate + CDPcholine
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?
CTP + choline phosphate
diphosphate + CDPcholine
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?
CTP + choline phosphate
diphosphate + CDPcholine
-
catalyzes a major rate-limiting step in the biosynthesis of phosphocholine
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?
CTP + choline phosphate
diphosphate + CDPcholine
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-
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?
CTP + choline phosphate
diphosphate + CDPcholine
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?
CTP + choline phosphate
diphosphate + CDPcholine
highly specific for CTP or dCTP
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?
CTP + choline phosphate
diphosphate + CDPcholine
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ATP can replace CTP with less efficiency
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?
CTP + choline phosphate
diphosphate + CDPcholine
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plays a role in the biosynthesis of the phosphocholine-derivatized cell wall constituents that are critical for cell separation and pathogenesis
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?
CTP + choline phosphate
diphosphate + CDPcholine
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biosynthesis of the choline containing cell wall antigens, teichoic acid and lipoteichoic acid
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?
CTP + choline phosphate
diphosphate + CDPcholine
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?
CTP + choline phosphate
diphosphate + CDPcholine
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biosynthesis of the choline containing cell wall antigens, teichoic acid and lipoteichoic acid
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?
CTP + ethanolamine phosphate
diphosphate + CDPethanolamine
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?
CTP + ethanolamine phosphate
diphosphate + CDPethanolamine
-
poor substrate
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?
CTP + phosphocholine
diphosphate + CDP-choline
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?
CTP + phosphocholine
diphosphate + CDP-choline
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?
CTP + phosphocholine
diphosphate + CDP-choline
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?
CTP + phosphocholine
diphosphate + CDP-choline
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-
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?
CTP + phosphocholine
diphosphate + CDP-choline
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?
CTP + phosphocholine
diphosphate + CDP-choline
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?
CTP + phosphocholine
diphosphate + CDP-choline
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?
CTP + phosphocholine
diphosphate + CDP-choline
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?
CTP + phosphocholine
diphosphate + CDP-choline
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?
CTP + phosphocholine
diphosphate + CDP-choline
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?
CTP + phosphocholine
diphosphate + CDP-choline
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?
CTP + phosphocholine
diphosphate + CDP-choline
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?
CTP + phosphocholine
diphosphate + CDP-choline
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?
CTP + phosphocholine
diphosphate + CDP-choline
when dissociated from membranes, a portion of the M domain functions as an auto-inhibitory element to suppress catalysis. It is proposed that membrane binding enables bending of thex02E helices, bringing the active site closer to the membrane surface
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?
CTP + phosphomonomethylethanolamine
diphosphate + CDPmethylethanolamine
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?
CTP + phosphomonomethylethanolamine
diphosphate + CDPmethylethanolamine
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?
additional information
?
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key regulatory enzyme in the CDP-choline pathway for the biosynthesis of phosphatidylcholine, hepatic phosphatidylcholine biosynthesis is an important regulator of plasma high density lipoprotein
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additional information
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active lipoprotein form, i.e. H-form, is the membrane-associated form of the enzyme in adult lung
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additional information
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comparison of lipid regulation of yeast and rat enzyme
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additional information
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H-form is the active form of enzyme in cytoplasm
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additional information
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change in relative distribution of H-form and L-form in cytosol may be important in the regulation of phosphatidylcholine synthesis
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?
additional information
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active form of enzyme on the ER, enzyme in cytosol appears to be latent
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?
additional information
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CTbeta2 facilitates neurite outgrowth and branching
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?
additional information
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development of an assay method for determination of the catalytic activity measuring the production of radiolabeled CDP-choline from 14C-labeled phosphocholine, and separation of non-radioactive CDP-choline from CTP by C18 reverse phase HPLC using a mobile phase of 0.1 M ammonium bicarbonate (98%) and acetonitrile (2%) at pH 7.4, evaluation, overview
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?
additional information
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no substrates: ethanolamine phosphate and phosphodimethylethanolamine
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?
additional information
?
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comparison of lipid regulation of yeast and rat enzyme
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?