2.7.7.19: polynucleotide adenylyltransferase

This is an abbreviated version!
For detailed information about polynucleotide adenylyltransferase, go to the full flat file.

Reaction

Synonyms

AAS, adenosine triphosphate:ribonucleic acid adenylyltransferase, AMP polynucleotidylexotransferase, ATP-polynucleotide adenylyltransferase, ATP:polynucleotidylexotransferase, CC-adding enzyme, Cid1, Cid14, FAM46A, FAM46B, FAM46C, FAM46D, germline development 2, GLD-2, GLD2, GLD4, Hs2, MTPAP, neo-PAP, non-canonical poly(A) RNA polymerase PAPD7, NTP polymerase, nuclear poly(A) polymerase 1, nuclear speckle targeted PIPKIalpha regulated-poly(A) polymerase, nucleotidyltransferase, polyadenylate, PAP, PAP I, Pap II, PAP1, Pap1p, PAPalpha, PAPbeta, PapD1, PapD5, PAPD7, PAPgamma, PAPOLA, PAPOLB/TPAP, PAPOLG, PAPS1, PAPS2, PAPS4, PcnB, pcnB2, pcnB2 aq_2158, poly A polymerase, poly(A) hydrolase, poly(A) polymerase, poly(A) polymerase gamma, poly(A) polymerase I, poly(A) polymerase II, poly(A) RNA polymerase protein 1, poly(A) synthetase, poly(A)-polymerase, poly(A)polymerase I, polyA polymerase, polyadenylate nucleotidyltransferase, polyadenylate polymerase, polyadenylate synthetase, polyadenylic acid polymerase, polyadenylic polymerase, poly[A] polymerase beta, RNA adenylating enzyme, RNA formation factors, PF1, RNA poly(A) polymerase, Star-PAP, Tb927.3.3160, Tb927.7.3780, terminal riboadenylate transferase, Tpap, Trf5, Trf5p, TUT1, TUTase1, VP55, Wisp, yPAP, ZCCHC6

ECTree

     2 Transferases

         2.7 Transferring phosphorus-containing groups

             2.7.7 Nucleotidyltransferases

                2.7.7.19 polynucleotide adenylyltransferase

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Results	in table
12	Activating Compound
28207	AA Sequence
6	Application
1	CAS Registry Number
34	Cloned(Commentary)
3	Cofactor
15	Crystallization (Commentary)
700	Disease/ Diagnostics
3	Expression
44	General Information
4	General Stability
246	Inhibitors
3	kcat/KM [mM/s]
8	Ki Value [mM]
126	KM Value [mM]
93	Localization
120	Metals/Ions
75	Molecular Weight [Da]
38	Natural Substrates/ Products (Substrates)
248	Organism
110	PDB ID
19	pH Optimum
15	pH Range
7	Posttranslational Modification
80	Protein Variants
64	Purification (Commentary)
14	Reaction
1	Reaction Type
156	Reference
3	Renatured (Commentary)
129	Source Tissue
14	Specific Activity [micromol/min/mg]
10	Storage Stability
317	Substrates and Products (Substrate)
50	Subunits
200	Synonyms
1	Systematic Name
3	Temperature Optimum [°C]
5	Temperature Stability [°C]
53	Turnover Number [1/s]

General Stability

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General Stability on EC 2.7.7.19 - polynucleotide adenylyltransferase

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GENERAL STABILITY

ORGANISM

UNIPROT

LITERATURE

a decay of PAP activity with a half-life of approximately 2 h (on ice) is observed when Nonidet-P 40 is omitted from the enzyme storage solution

Saccharomyces cerevisiae

-

661205

freezing and thawing accelerates inactivation

Bos taurus

-

642944

substrates poly(A) and Mg-ATP induce the conformational change, resulting in stabilization of the closed enzyme state and enabling catalysis

Saccharomyces cerevisiae

P29468

677164

the protein undergoes structural modifications upon RNA binding, although the interaction does not significantly modify the stability of the protein

Candida albicans

-

677275