2.7.7.22: mannose-1-phosphate guanylyltransferase (GDP)
This is an abbreviated version!
For detailed information about mannose-1-phosphate guanylyltransferase (GDP), go to the full flat file.
Word Map on EC 2.7.7.22
Reaction
Synonyms
GDP mannose phosphorylase, GDP-D-mannose pyrophosphorylase, GDP-mannose 1-phosphate guanylyltransferase, GDP:D-mannose-1-phosphate guanylyltransferase, GDPmannose phosphorylase, GMP, GMP3, GMPase, guanosine diphosphate-mannose 1-phosphate guanylyltransferase, guanosine diphosphomannose phosphorylase, guanylyltransferase, mannose 1-phosphate (guanosine diphosphate), mannose 1-phosphate guanylyltransferase, More, SGN-U568547
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2.7.7.22 mannose-1-phosphate guanylyltransferase (GDP)Advanced search results
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Substrates Products on EC 2.7.7.22 - mannose-1-phosphate guanylyltransferase (GDP)
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SUBSTRATE 
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
GDP + alpha-D-mannose 1-phosphate
phosphate + GDP-mannose
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GMP catalyzes the synthesis of GDP-mannose, an important step in the formation of all guanosine-containing sugar nucleotides in plants. The GDP-mannose produced by the enzymatic action of GMP plays vital roles in both prokaryotes and eukaryotes, overview. The enzyme activity is correlated to the amount of ascorbic acid, overview
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?
GDPmannose + phosphate
GDP + mannose 1-phosphate
reverse reaction involved in synthesis of the compatible solute alpha-mannosylglycerate
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r
additional information
?
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GDP-mannose, the mannose donor, required for the main cryptococcal virulence factor, a polysaccharide capsule that surrounds the cell, is produced in the cytosol by the sequential actions of phosphomannose isomerase, phosphomannomutase, and GDP-mannose pyrophosphorylase. Cryptococcus neoformans is a fungal pathogen that is responsible for life-threatening disease, particularly in the context of compromised immunity
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?
additional information
?
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GMP is an important enzyme in the Smirnoff-Wheelers pathway for the biosynthesis of ascorbic acid in plants
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?
additional information
?
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the essential enzyme plays a major role in the Smirnoff-Wheelers L-ascorbic acid biosynthetic pathway in plants
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?
additional information
?
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diphosphate cannot substitute for phosphate
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?
