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2.7.7.24: glucose-1-phosphate thymidylyltransferase

This is an abbreviated version!
For detailed information about glucose-1-phosphate thymidylyltransferase, go to the full flat file.

Word Map on EC 2.7.7.24

Reaction

dTTP
+
alpha-D-glucose 1-phosphate
=
diphosphate
 +
dTDP-alpha-D-glucose

Synonyms

Cps23FL, Cps2L, D-glucose-1-phosphate thymidylyltransferase, DnmL, dTDP-alpha-D-glucose pyrophosphorylase, dTDP-D-glucose synthase, dTDP-glucose synthase, dTDP-glucose-pyrophosphorylase, dTDPglucose pyrophosphorylase, Glc-1-P thymidylyltransferase, Glc-1-P TTase, Glc-1-P-TT, Glc1P-thymidylyltransferase, glucose 1-phosphate thymidylyltransferase, glucose-1-phosphate thymidylyltransferase, RfbA, rml-1, RmlA, RmlA protein, SchS6, SgcA1, ST0452, sugar-1-phosphate nucleotidyltransferase, TDP-glucose pyrophosphorylase, thymidine diphosphate glucose pyrophosphorylase, thymidine diphosphoglucose pyrophosphorylase, thymidylyltransferase, glucose 1-phosphate, ugpG, UgpG protein, UTP/dTTP-glucose-1-phosphate uridylyl/thymidylyl transferase

ECTree

     2 Transferases
         2.7 Transferring phosphorus-containing groups
             2.7.7 Nucleotidyltransferases
                2.7.7.24 glucose-1-phosphate thymidylyltransferase

Inhibitors

Inhibitors on EC 2.7.7.24 - glucose-1-phosphate thymidylyltransferase

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INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
(1S,2R,3S,4S,5R,6S)-2,3,4,5,6-pentahydroxycyclohexyl dihydrogen phosphate
-
mixed inhibition type
Ca2+
strong inhibition at 10 mM
Cu2+
strong inhibition at 10 mM
deoxythymidine 5'-tetraphosphate
-
bisubstrate inhibitor with increased length of polyphosphate linker, competitve inhibition
dTDP-glucose
-
competitive to dTTP
dTDP-L-rhamnose
-
-
dTTP
-
competitive to dTDPglucose and non-competitive to alpha-D-glucose 1-phosphate
Fe2+
strong inhibition at 10 mM
K+
complete inhibition at 10 mM
Mn2+
strong inhibition at 10 mM
N-(6-amino-1-benzyl-1,2,3,4-tetrahydropyrimidin-5-yl)-N-methylbenzenesulfonamide
inhibitor does not bind at the active site of RmlA but binds at a second site remote from the active site. Despite this, the compound acts as competitive inhibitor but with high cooperativity
N-(6-amino-1-benzyl-1,2,3,4-tetrahydropyrimidin-5-yl)-N-methylbutane-1-sulfonamide
inhibitor does not bind at the active site of RmlA but binds at a second site remote from the active site. Despite this, the compound acts as competitive inhibitor but with high cooperativity
N-(6-amino-1-benzyl-1,2,3,4-tetrahydropyrimidin-5-yl)-N-methylfuran-2-sulfonamide
inhibitor does not bind at the active site of RmlA but binds at a second site remote from the active site. Despite this, the compound acts as competitive inhibitor but with high cooperativity
Na+
complete inhibition at 10 mM
Ni2+
complete inhibition at 10 mM
Zn2+
complete inhibition at 10 mM
[2-[(2R,3R,4R,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl]ethyl]phosphonic acid
-
competitive inhibition