2.7.7.3: pantetheine-phosphate adenylyltransferase

This is an abbreviated version!
For detailed information about pantetheine-phosphate adenylyltransferase, go to the full flat file.

Word Map on EC 2.7.7.3

2.7.7.3

ppats

penultimate

dpcoa

pantothen

pyrophosphate

hexameric

3\'-dephospho-coa

nucleotidyltransferase

dephosphocoenzyme

phosphopantothenoylcysteine

medicine

drug development

Reaction

Synonyms

3'-dephospho-CoA pyrophosphorylase, 4'-phosphopantetheine adenylyltransferase, 4-phosphopantetheine adenylyltransferase, CoaD, dephospho-CoA pyrophosphorylase, dephospho-coenzyme A pyrophosphorylase, Enterococcus faecalis PPAT, More, pantetheine phosphate adenylyltransferase, phosphopantetheine adenylyltransferase, PPAT

ECTree

2 Transferases

2.7 Transferring phosphorus-containing groups

2.7.7 Nucleotidyltransferases

2.7.7.3 pantetheine-phosphate adenylyltransferase

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Results	in table
4	Activating Compound
39402	AA Sequence
5	Application
1	CAS Registry Number
27	Cloned(Commentary)
25	Crystallization (Commentary)
15	Disease/ Diagnostics
18	General Information
70	IC50 Value
115	Inhibitors
12	Ki Value [mM]
25	KM Value [mM]
20	Localization
12	Metals/Ions
22	Molecular Weight [Da]
42	Natural Substrates/ Products (Substrates)
194	Organism
7	Pathway
261	PDB ID
15	pH Optimum
3	pH Stability
1	pI Value
13	Protein Variants
27	Purification (Commentary)
1	Reaction
2	Reaction Type
77	Reference
16	Source Tissue
7	Specific Activity [micromol/min/mg]
1	Storage Stability
80	Substrates and Products (Substrate)
31	Subunits
81	Synonyms
1	Systematic Name
19	Temperature Optimum [°C]
3	Temperature Stability [°C]
4	Turnover Number [1/s]

Disease

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Disease on EC 2.7.7.3 - pantetheine-phosphate adenylyltransferase

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Cross Infection

Umbrella Sampling and X-ray Crystallographic Analysis Unveil an Arg-Asp Gate Facilitating Inhibitor Binding Inside Phosphopantetheine Adenylyltransferase Allosteric Cleft.

29345931

Pulmonary Disease, Chronic Obstructive

Rapid countermeasure discovery against Francisella tularensis based on a metabolic network reconstruction.

23704901

Respiratory Insufficiency

Umbrella Sampling and X-ray Crystallographic Analysis Unveil an Arg-Asp Gate Facilitating Inhibitor Binding Inside Phosphopantetheine Adenylyltransferase Allosteric Cleft.

29345931

Tuberculosis

Design of Novel Phosphopantetheine Adenylyltransferase Inhibitors: a Potential New Approach to Tackle Mycobacterium tuberculosis.

34323186

Kinetic, Thermodynamic, and Structural Insight into the Mechanism of Phosphopantetheine Adenylyltransferase from Mycobacterium tuberculosis.

20851704

Rhombohedral crystals of Mycobacterium tuberculosis phosphopantetheine adenylyltransferase.

14684928

Structure of Mycobacterium tuberculosis phosphopantetheine adenylyltransferase in complex with the feedback inhibitor CoA reveals only one active-site conformation.

21543857

Substrate-induced asymmetry and channel closure revealed by the apoenzyme structure of Mycobacterium tuberculosis phosphopantetheine adenylyltransferase.

15322293

X-ray study of the conformational changes in the molecule of phosphopantetheine adenylyltransferase from Mycobacterium tuberculosis during the catalyzed reaction.

23151631