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2.7.7.30: fucose-1-phosphate guanylyltransferase

This is an abbreviated version!
For detailed information about fucose-1-phosphate guanylyltransferase, go to the full flat file.

Word Map on EC 2.7.7.30

Reaction

GTP
+
beta-L-fucose 1-phosphate
=
diphosphate
 +
GDP-L-fucose

Synonyms

AtFKGP, FKP, GDP-fucose pyrophosphorylase, GDP-L-Fuc pyrophosphorylase, GDP-L-fucose pyrophosphorylase, GDP-L-fucose pyrophosphorylase (Fpgt), GDP-L-fucose-synthesizing enzymes, GDPfucose pyrophosphorylase, GFPP, GTP fucose pyrophosphorylase, GTP fucose pyrophosphorylase (GFPP), guanosine 5'-diphosphate-L-fucose pyrophosphorylase, guanosine diphosphate L-fucose pyrophosphorylase, guanosine triphosphate fucose pyrophosphorylase (GFPP), L-fucokinase/GDP-fucose pyrophosphorylase

ECTree

     2 Transferases
         2.7 Transferring phosphorus-containing groups
             2.7.7 Nucleotidyltransferases
                2.7.7.30 fucose-1-phosphate guanylyltransferase

Engineering

Engineering on EC 2.7.7.30 - fucose-1-phosphate guanylyltransferase

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PROTEIN VARIANTS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
A723R
-
the mutant shows about 75% GDP-fucose pyrophosphorylase activity compared to the wild type enzyme
D594A
-
the mutant shows about 55% GDP-fucose pyrophosphorylase activity compared to the wild type enzyme
D601A
-
the mutant shows about 40% GDP-fucose pyrophosphorylase activity compared to the wild type enzyme
D762A
-
the mutant shows about 85% GDP-fucose pyrophosphorylase activity compared to the wild type enzyme
G597A
-
the mutant shows about 20% GDP-fucose pyrophosphorylase activity compared to the wild type enzyme
G598A
-
the mutant shows about 90% GDP-fucose pyrophosphorylase activity compared to the wild type enzyme
G713A
-
the mutant shows about 125% GDP-fucose pyrophosphorylase activity compared to the wild type enzyme
G715A
-
the mutant shows wild type GDP-fucose pyrophosphorylase activity
G717A
-
the mutant shows wild type GDP-fucose pyrophosphorylase activity
G757A
-
the mutant shows wild type GDP-fucose pyrophosphorylase activity
G758A
-
the mutant shows wild type GDP-fucose pyrophosphorylase activity
G759A
-
the mutant shows about 85% GDP-fucose pyrophosphorylase activity compared to the wild type enzyme
G75A
-
the mutant shows about 60% GDP-fucose pyrophosphorylase activity compared to the wild type enzyme
G76A
-
the mutant almost completely loses its GDP-fucose pyrophosphorylase activity
G88A
-
the mutant almost completely loses its GDP-fucose pyrophosphorylase activity
G899A
-
the mutant shows about 90% GDP-fucose pyrophosphorylase activity compared to the wild type enzyme
G901A
-
the mutant shows about 87% GDP-fucose pyrophosphorylase activity compared to the wild type enzyme
G902A
-
the mutant shows about 80% GDP-fucose pyrophosphorylase activity compared to the wild type enzyme
H73A
-
the mutant shows about 40% GDP-fucose pyrophosphorylase activity compared to the wild type enzyme
I721A
-
the mutant shows about 90% GDP-fucose pyrophosphorylase activity compared to the wild type enzyme
K89A
-
the mutant almost completely loses its GDP-fucose pyrophosphorylase activity
L722A
-
the mutant shows about 120% GDP-fucose pyrophosphorylase activity compared to the wild type enzyme
P711A
-
the mutant shows about 120% GDP-fucose pyrophosphorylase activity compared to the wild type enzyme
R592A
-
the mutant shows about 110% GDP-fucose pyrophosphorylase activity compared to the wild type enzyme
R80A
-
the mutant almost completely loses its GDP-fucose pyrophosphorylase activity
R82A
-
the mutant shows about 50% GDP-fucose pyrophosphorylase activity compared to the wild type enzyme
S714A
-
the mutant shows about 130% GDP-fucose pyrophosphorylase activity compared to the wild type enzyme
S719A
-
the mutant shows about 90% GDP-fucose pyrophosphorylase activity compared to the wild type enzyme
S720A
-
the mutant shows about 75% GDP-fucose pyrophosphorylase activity compared to the wild type enzyme
S78A
-
the mutant shows about 80% GDP-fucose pyrophosphorylase activity compared to the wild type enzyme
T602A
-
the mutant shows about 90% GDP-fucose pyrophosphorylase activity compared to the wild type enzyme
T718A
-
the mutant shows wild type GDP-fucose pyrophosphorylase activity
G75A
-
the mutant shows about 60% GDP-fucose pyrophosphorylase activity compared to the wild type enzyme
-
H73A
-
the mutant shows about 40% GDP-fucose pyrophosphorylase activity compared to the wild type enzyme
-
K89A
-
the mutant almost completely loses its GDP-fucose pyrophosphorylase activity
-
R80A
-
the mutant almost completely loses its GDP-fucose pyrophosphorylase activity
-
R82A
-
the mutant shows about 50% GDP-fucose pyrophosphorylase activity compared to the wild type enzyme
-
D184A
-
the ratio of turnover number to Km-value (for GTP) is 1.02fold higher than the wild-type ratio
D299A
-
the ratio of turnover number to Km-value (for GTP) is 1.04fold higher than the wild-type ratio
D427A
-
the ratio of turnover number to Km-value (for GTP) is 1.06fold lower than the wild-type ratio
D77A
-
the ratio of turnover number to Km-value (for GTP) is 16600fold lower than the wild-type ratio
E289A
-
the ratio of turnover number to Km-value (for GTP) is 1.1fold lower than the wild-type ratio
E297A
-
the ratio of turnover number to Km-value (for GTP) is 19.5fold lower than the wild-type ratio
E297A/E432A
-
the ratio of turnover number to Km-value (for GTP) is 24900fold lower than the wild-type ratio
E432A
-
the ratio of turnover number to Km-value (for GTP) is 113fold lower than the wild-type ratio
E566A
-
the ratio of turnover number to Km-value (for GTP) is 1.06fold higher than the wild-type ratio
E574A
-
the ratio of turnover number to Km-value (for GTP) is 1.05fold lower than the wild-type ratio
K478A
-
the ratio of turnover number to Km-value (for GTP) is 1.13fold lower than the wild-type ratio
K479A
-
the ratio of turnover number to Km-value (for GTP) is 1.15fold lower than the wild-type ratio
K482A
-
the ratio of turnover number to Km-value (for GTP) is 166fold lower than the wild-type ratio