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2.7.7.39: glycerol-3-phosphate cytidylyltransferase

This is an abbreviated version!
For detailed information about glycerol-3-phosphate cytidylyltransferase, go to the full flat file.

Word Map on EC 2.7.7.39

Reaction

CTP
+
sn-glycerol 3-phosphate
=
diphosphate
+
CDP-glycerol

Synonyms

AQ1368, AQ185, CDP-glycerol pyrophosphorylase, CDPglycerol pyrophosphorylase, CTP:glycerol 3-phosphate cytidylyltransferase, CTP:glycerol-3-phosphate cytidylyltransferase, cytidine diphosphate glycerol pyrophosphorylase, cytidine diphosphoglycerol pyrophosphorylase, cytidylyltransferase, cytidylyltransferase, glycerol 3-phosphate, GCT, glycerol 3-phosphate cytidylyltransferase, glycerol phosphate cytidylyltransferase, Gro-PCT, TarD, TarDSa

ECTree

     2 Transferases
         2.7 Transferring phosphorus-containing groups
             2.7.7 Nucleotidyltransferases
                2.7.7.39 glycerol-3-phosphate cytidylyltransferase

Engineering

Engineering on EC 2.7.7.39 - glycerol-3-phosphate cytidylyltransferase

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PROTEIN VARIANTS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
C106A
-
mutant with kinetic constants similar to wild-type enzyme
D11A
-
mutant with low kcat value
D11E
-
mutant with low kcat value
D38A
-
mutant with high Km value
D38E
-
kcat similar to wild-type enzyme
D66A
-
mutant with low kcat value, defective in overall structure
D66E
-
mutant with low kcat value
D87A
-
mutant with kinetic constants similar to wild-type enzyme
D92A
-
mutant with kinetic constants similar to wild-type enzyme
D94A/H14A
-
binding constants for CTP and glycerol 3-phosphate are similar to wild-type enzyme
D94E mutant
-
mutant with low kcat value
E115A
-
mutant with kinetic constants similar to wild-type enzyme
E39A
-
mutant with kinetic constants similar to wild-type enzyme
E67A
-
mutant with kinetic constants similar to wild-type enzyme
H84A
-
mutant with low kcat value
K103A
-
mutant with kinetic constants similar to wild-type enzyme
K19A
-
mutant with kinetic constants similar to wild-type enzyme
K22A
-
mutant with kinetic constants similar to wild-type enzyme
K25A
-
mutant with kinetic constants similar to wild-type enzyme
K44A
less active than wild-type enzyme
K46A
less active than wild-type enzyme
R113A
-
mutant with low kcat value
R113K
-
mutant with low kcat value
R55A
-
mutant with low kcat value
R55K
-
mutant with low kcat value
R63A
-
mutant with low kcat value
S118A
-
mutant with low kcat value t
T114A
-
mutant with low kcat value
T119A
-
mutant with low kcat value
W74A
-
mutant with high Km value