2.7.7.42: [glutamine synthetase] adenylyltransferase

This is an abbreviated version!
For detailed information about [glutamine synthetase] adenylyltransferase, go to the full flat file.

Reaction

Synonyms

adenosine triphosphate:glutamine synthetase adenylyltransferase, adenylyltransferase, adenylyltransferase, glutamine synthetase, ATASE, ATP:glutamine synthetase adenylyltransferase, ATP:[L-glutamate:ammonia ligase (ADP-forming)] adenylyl transferase, GlnE, glutamine synthetase adenylyl transferase, glutamine synthetase adenylyltransferase, glutamine synthetase ATase, glutamine-synthetase adenylyltransferase, GS ATase, [glutamate-ammonia-ligase] adenylyltransferase

ECTree

     2 Transferases

         2.7 Transferring phosphorus-containing groups

             2.7.7 Nucleotidyltransferases

                2.7.7.42 [glutamine synthetase] adenylyltransferase

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Results	in table
42	Activating Compound
16628	AA Sequence
1	CAS Registry Number
8	Cloned(Commentary)
17	Cofactor
4	Crystallization (Commentary)
2	Expression
7	General Information
5	General Stability
34	Inhibitors
10	Ki Value [mM]
18	KM Value [mM]
23	Metals/Ions
5	Molecular Weight [Da]
22	Natural Substrates/ Products (Substrates)
946	Organism
3	PDB ID
9	pH Optimum
1	pH Range
3	pH Stability
2	pI Value
26	Protein Variants
10	Purification (Commentary)
3	Reaction
6	Reaction Type
40	Reference
5	Specific Activity [micromol/min/mg]
3	Storage Stability
59	Substrates and Products (Substrate)
1	Subunits
46	Synonyms
1	Systematic Name
10	Temperature Optimum [°C]
1	Temperature Range [°C]

Natural Substrates Products

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Natural Substrates Products on EC 2.7.7.42 - [glutamine synthetase] adenylyltransferase

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NATURAL SUBSTRATE

NATURAL PRODUCT

REACTION DIAGRAM

ORGANISM

UNIPROT

COMMENTARY
(Substrate)

LITERATURE
(Substrate)

COMMENTARY
(Product)

LITERATURE
(Product)

REVERSIBILITY
r=reversible
ir=irreversible
?=not specified

ADP + glutamine synthetase

adenyl-[glutamine synthetase] + phosphate

Escherichia coli

-

-

702300

-

-

r

ATP + glutamine synthetase

adenylated glutamine synthetase + diphosphate

Azospirillum brasilense

A7Y9V0

-

706703

-

-

r

ATP + glutamine synthetase

glutamine synthetase-AMP + diphosphate

Escherichia coli

P30870

the enzyme has two activities, adenylyl removase and adenylyl transferase, which are located in distinct catalytic domains that are separated by a regulatory domain

705180

-

-

?

ATP + [glutamine synthetase]-L-tyrosine

diphosphate + [glutamine synthetase]-O4-(5'-adenylyl)-L-tyrosine

2 entries

ATP + [L-glutamate:ammonia ligase (ADP-forming)]

diphosphate + [L-glutamate:ammonia ligase (ADP-forming)] -(AMP)

13 entries

glutamine synthase + ATP

adenylyl-[glutamine synthase] + diphosphate

Rhodospirillum rubrum

-

ATase primarily regulated by alpha-ketoglutarate, glutamine has no effect on neither the adenylylation nor the deadenylylation of glutamine synthetase, PII proteins only stimulate the adenylylation reaction

673590

-

-

r

glutamine synthetase-AMP + phosphate

ADP + glutamine synthetase

Escherichia coli

P30870

the enzyme has two activities, adenylyl removase and adenylyl transferase, which are located in distinct catalytic domains that are separated by a regulatory domain

705180

-

-

?

additional information

?

-

2 entries

ATP + [glutamine synthetase]-L-tyrosine

diphosphate + [glutamine synthetase]-O4-(5'-adenylyl)-L-tyrosine

Mycobacterium tuberculosis

P9WN27

-

762231

-

-

?

ATP + [glutamine synthetase]-L-tyrosine

diphosphate + [glutamine synthetase]-O4-(5'-adenylyl)-L-tyrosine

Mycobacterium tuberculosis H37Rv

P9WN27

-

762231

-

-

?

ATP + [L-glutamate:ammonia ligase (ADP-forming)]

diphosphate + [L-glutamate:ammonia ligase (ADP-forming)] -(AMP)

Corynebacterium glutamicum

Q79VE2

enzyme is responsible for regulation of [L-glutamate:ammonia ligase (ADP-forming)] activity

643336

-

643336

?

ATP + [L-glutamate:ammonia ligase (ADP-forming)]

diphosphate + [L-glutamate:ammonia ligase (ADP-forming)] -(AMP)

Escherichia coli

-

-

643334

-

643334

?

ATP + [L-glutamate:ammonia ligase (ADP-forming)]

diphosphate + [L-glutamate:ammonia ligase (ADP-forming)] -(AMP)

Escherichia coli

-

-

643329

-

643329

r

ATP + [L-glutamate:ammonia ligase (ADP-forming)]

diphosphate + [L-glutamate:ammonia ligase (ADP-forming)] -(AMP)

Escherichia coli

-

-

643330

-

643330

r

ATP + [L-glutamate:ammonia ligase (ADP-forming)]

diphosphate + [L-glutamate:ammonia ligase (ADP-forming)] -(AMP)

Escherichia coli

-

-

643333

-

643333

r

ATP + [L-glutamate:ammonia ligase (ADP-forming)]

diphosphate + [L-glutamate:ammonia ligase (ADP-forming)] -(AMP)

Escherichia coli

-

enzyme is involved in the regulation of nitrogen assimilation

643335

-

643335

r

ATP + [L-glutamate:ammonia ligase (ADP-forming)]

diphosphate + [L-glutamate:ammonia ligase (ADP-forming)] -(AMP)

Escherichia coli

-

inactivation of [L-glutamate:ammonia ligase (ADP-forming)] by attachment of the adenylyl moiety of ATP

643331

-

643331

r

ATP + [L-glutamate:ammonia ligase (ADP-forming)]

diphosphate + [L-glutamate:ammonia ligase (ADP-forming)] -(AMP)

Escherichia coli

-

inactivation of [L-glutamate:ammonia ligase (ADP-forming)] by attachment of the adenylyl moiety of ATP

643332

-

643332

r

ATP + [L-glutamate:ammonia ligase (ADP-forming)]

diphosphate + [L-glutamate:ammonia ligase (ADP-forming)] -(AMP)

Escherichia coli B / ATCC 11303

-

-

643329

-

643329

r

ATP + [L-glutamate:ammonia ligase (ADP-forming)]

diphosphate + [L-glutamate:ammonia ligase (ADP-forming)] -(AMP)

Escherichia coli B / ATCC 11303

-

-

643330

-

643330

r

ATP + [L-glutamate:ammonia ligase (ADP-forming)]

diphosphate + [L-glutamate:ammonia ligase (ADP-forming)] -(AMP)

Escherichia coli B / ATCC 11303

-

inactivation of [L-glutamate:ammonia ligase (ADP-forming)] by attachment of the adenylyl moiety of ATP

643332

-

643332

r

ATP + [L-glutamate:ammonia ligase (ADP-forming)]

diphosphate + [L-glutamate:ammonia ligase (ADP-forming)] -(AMP)

Pseudomonas putida

-

-

643333

-

643333

r

ATP + [L-glutamate:ammonia ligase (ADP-forming)]

diphosphate + [L-glutamate:ammonia ligase (ADP-forming)] -(AMP)

Salmonella enterica subsp. enterica serovar Typhimurium

-

-

643333

-

643333

r

additional information

?

-

Escherichia coli

-

signal transduction system in nitrogen assimilation of Escherichia coli

643335

-

-

?

additional information

?

-

Escherichia coli

-

enzyme is regulated by glutamine, 2-oxoglutarate and the regulatory enzymes PII and GlnK

643335

-

-

?