2.7.7.42: [glutamine synthetase] adenylyltransferase

This is an abbreviated version!
For detailed information about [glutamine synthetase] adenylyltransferase, go to the full flat file.

Reaction

Synonyms

adenosine triphosphate:glutamine synthetase adenylyltransferase, adenylyltransferase, adenylyltransferase, glutamine synthetase, ATASE, ATP:glutamine synthetase adenylyltransferase, ATP:[L-glutamate:ammonia ligase (ADP-forming)] adenylyl transferase, GlnE, glutamine synthetase adenylyl transferase, glutamine synthetase adenylyltransferase, glutamine synthetase ATase, glutamine-synthetase adenylyltransferase, GS ATase, [glutamate-ammonia-ligase] adenylyltransferase

ECTree

     2 Transferases

         2.7 Transferring phosphorus-containing groups

             2.7.7 Nucleotidyltransferases

                2.7.7.42 [glutamine synthetase] adenylyltransferase

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Results	in table
42	Activating Compound
16628	AA Sequence
1	CAS Registry Number
8	Cloned(Commentary)
17	Cofactor
4	Crystallization (Commentary)
2	Expression
7	General Information
5	General Stability
34	Inhibitors
10	Ki Value [mM]
18	KM Value [mM]
23	Metals/Ions
5	Molecular Weight [Da]
22	Natural Substrates/ Products (Substrates)
946	Organism
3	PDB ID
9	pH Optimum
1	pH Range
3	pH Stability
2	pI Value
26	Protein Variants
10	Purification (Commentary)
3	Reaction
6	Reaction Type
40	Reference
5	Specific Activity [micromol/min/mg]
3	Storage Stability
59	Substrates and Products (Substrate)
1	Subunits
46	Synonyms
1	Systematic Name
10	Temperature Optimum [°C]
1	Temperature Range [°C]

Substrates Products

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Substrates Products on EC 2.7.7.42 - [glutamine synthetase] adenylyltransferase

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SUBSTRATE

PRODUCT                       

REACTION DIAGRAM

ORGANISM

UNIPROT

COMMENTARY
(Substrate)

LITERATURE
(Substrate)

COMMENTARY
(Product)

LITERATURE
(Product)

Reversibility
r=reversible
ir=irreversible
?=not specified

adenylyl-[glutamine synthase] + phosphate

glutamine synthase + ADP

3 entries

ADP + glutamine synthetase

adenyl-[glutamine synthetase] + phosphate

Escherichia coli

-

-

702300

-

-

r

ATP + glutamine synthetase

adenylated glutamine synthetase + diphosphate

2 entries

ATP + glutamine synthetase

glutamine synthetase-AMP + diphosphate

Escherichia coli

P30870

the enzyme has two activities, adenylyl removase and adenylyl transferase, which are located in distinct catalytic domains that are separated by a regulatory domain

705180

-

-

?

ATP + [glutamine synthetase]-L-tyrosine

diphosphate + [glutamine synthetase]-O4-(5'-adenylyl)-L-tyrosine

4 entries

ATP + [L-glutamate:ammonia ligase (ADP-forming)]

diphosphate + [L-glutamate:ammonia ligase (ADP-forming)] -(AMP)

13 entries

ATP + [L-glutamate:ammonia ligase (ADP-forming)]

diphosphate + [L-glutamate:ammonia ligase (ADP-forming)]-(AMP)

21 entries

glutamine synthase + ATP

adenylyl-[glutamine synthase] + diphosphate

4 entries

glutamine synthetase-AMP + phosphate

ADP + glutamine synthetase

Escherichia coli

P30870

the enzyme has two activities, adenylyl removase and adenylyl transferase, which are located in distinct catalytic domains that are separated by a regulatory domain

705180

-

-

?

[L-glutamate:ammonia ligase (ADP-forming)]-O4-(5'-adenylyl)-L-tyrosine + H2O

adenylate + [L-glutamate:ammonia ligase (ADP-forming)]-L-tyrosine

Escherichia coli

-

-

733319

-

-

?

additional information

?

-

5 entries

adenylyl-[glutamine synthase] + phosphate

glutamine synthase + ADP

Escherichia coli

-

adenylyl-removing reaction

672242

-

-

r

adenylyl-[glutamine synthase] + phosphate

glutamine synthase + ADP

Escherichia coli

-

deadenylylation reaction

672243, 673595

-

-

r

adenylyl-[glutamine synthase] + phosphate

glutamine synthase + ADP

Escherichia coli YMC10

-

adenylyl-removing reaction

672242

-

-

r

ATP + glutamine synthetase

adenylated glutamine synthetase + diphosphate

Azospirillum brasilense

A7Y9V0

-

706703

-

-

r

ATP + glutamine synthetase

adenylated glutamine synthetase + diphosphate

Escherichia coli

-

-

672243

-

-

?

ATP + [glutamine synthetase]-L-tyrosine

diphosphate + [glutamine synthetase]-O4-(5'-adenylyl)-L-tyrosine

Escherichia coli

-

-

643332

-

-

?

ATP + [glutamine synthetase]-L-tyrosine

diphosphate + [glutamine synthetase]-O4-(5'-adenylyl)-L-tyrosine

Escherichia coli B / ATCC 11303

-

-

643332

-

-

?

ATP + [glutamine synthetase]-L-tyrosine

diphosphate + [glutamine synthetase]-O4-(5'-adenylyl)-L-tyrosine

Mycobacterium tuberculosis

P9WN27

-

762231

-

-

?

ATP + [glutamine synthetase]-L-tyrosine

diphosphate + [glutamine synthetase]-O4-(5'-adenylyl)-L-tyrosine

Mycobacterium tuberculosis H37Rv

P9WN27

-

762231

-

-

?

ATP + [L-glutamate:ammonia ligase (ADP-forming)]

diphosphate + [L-glutamate:ammonia ligase (ADP-forming)] -(AMP)

Corynebacterium glutamicum

Q79VE2

enzyme is responsible for regulation of [L-glutamate:ammonia ligase (ADP-forming)] activity

643336

-

643336

?

ATP + [L-glutamate:ammonia ligase (ADP-forming)]

diphosphate + [L-glutamate:ammonia ligase (ADP-forming)] -(AMP)

Escherichia coli

-

-

643334

-

643334

?

ATP + [L-glutamate:ammonia ligase (ADP-forming)]

diphosphate + [L-glutamate:ammonia ligase (ADP-forming)] -(AMP)

Escherichia coli

-

-

643329

-

643329

r

ATP + [L-glutamate:ammonia ligase (ADP-forming)]

diphosphate + [L-glutamate:ammonia ligase (ADP-forming)] -(AMP)

Escherichia coli

-

-

643330

-

643330

r

ATP + [L-glutamate:ammonia ligase (ADP-forming)]

diphosphate + [L-glutamate:ammonia ligase (ADP-forming)] -(AMP)

Escherichia coli

-

-

643333

-

643333

r

ATP + [L-glutamate:ammonia ligase (ADP-forming)]

diphosphate + [L-glutamate:ammonia ligase (ADP-forming)] -(AMP)

Escherichia coli

-

enzyme is involved in the regulation of nitrogen assimilation

643335

-

643335

r

ATP + [L-glutamate:ammonia ligase (ADP-forming)]

diphosphate + [L-glutamate:ammonia ligase (ADP-forming)] -(AMP)

Escherichia coli

-

inactivation of [L-glutamate:ammonia ligase (ADP-forming)] by attachment of the adenylyl moiety of ATP

643331

-

643331

r

ATP + [L-glutamate:ammonia ligase (ADP-forming)]

diphosphate + [L-glutamate:ammonia ligase (ADP-forming)] -(AMP)

Escherichia coli

-

inactivation of [L-glutamate:ammonia ligase (ADP-forming)] by attachment of the adenylyl moiety of ATP

643332

-

643332

r

ATP + [L-glutamate:ammonia ligase (ADP-forming)]

diphosphate + [L-glutamate:ammonia ligase (ADP-forming)] -(AMP)

Escherichia coli B / ATCC 11303

-

-

643329

-

643329

r

ATP + [L-glutamate:ammonia ligase (ADP-forming)]

diphosphate + [L-glutamate:ammonia ligase (ADP-forming)] -(AMP)

Escherichia coli B / ATCC 11303

-

-

643330

-

643330

r

ATP + [L-glutamate:ammonia ligase (ADP-forming)]

diphosphate + [L-glutamate:ammonia ligase (ADP-forming)] -(AMP)

Escherichia coli B / ATCC 11303

-

inactivation of [L-glutamate:ammonia ligase (ADP-forming)] by attachment of the adenylyl moiety of ATP

643332

-

643332

r

ATP + [L-glutamate:ammonia ligase (ADP-forming)]

diphosphate + [L-glutamate:ammonia ligase (ADP-forming)] -(AMP)

Pseudomonas putida

-

-

643333

-

643333

r

ATP + [L-glutamate:ammonia ligase (ADP-forming)]

diphosphate + [L-glutamate:ammonia ligase (ADP-forming)] -(AMP)

Salmonella enterica subsp. enterica serovar Typhimurium

-

-

643333

-

643333

r

ATP + [L-glutamate:ammonia ligase (ADP-forming)]

diphosphate + [L-glutamate:ammonia ligase (ADP-forming)]-(AMP)

Corynebacterium glutamicum

Q79VE2

-

643336

-

643336

?

ATP + [L-glutamate:ammonia ligase (ADP-forming)]

diphosphate + [L-glutamate:ammonia ligase (ADP-forming)]-(AMP)

Escherichia coli

-

-

643334

-

643334

?

ATP + [L-glutamate:ammonia ligase (ADP-forming)]

diphosphate + [L-glutamate:ammonia ligase (ADP-forming)]-(AMP)

Escherichia coli

-

-

672242, 672243

-

-

?

ATP + [L-glutamate:ammonia ligase (ADP-forming)]

diphosphate + [L-glutamate:ammonia ligase (ADP-forming)]-(AMP)

Escherichia coli

-

-

643330

-

643330

r

ATP + [L-glutamate:ammonia ligase (ADP-forming)]

diphosphate + [L-glutamate:ammonia ligase (ADP-forming)]-(AMP)

Escherichia coli

-

-

643331

-

643331

r

ATP + [L-glutamate:ammonia ligase (ADP-forming)]

diphosphate + [L-glutamate:ammonia ligase (ADP-forming)]-(AMP)

Escherichia coli

-

-

643332

-

643332

r

ATP + [L-glutamate:ammonia ligase (ADP-forming)]

diphosphate + [L-glutamate:ammonia ligase (ADP-forming)]-(AMP)

Escherichia coli

-

-

643333

-

643333

r

ATP + [L-glutamate:ammonia ligase (ADP-forming)]

diphosphate + [L-glutamate:ammonia ligase (ADP-forming)]-(AMP)

Escherichia coli

-

-

643335

-

643335

r

ATP + [L-glutamate:ammonia ligase (ADP-forming)]

diphosphate + [L-glutamate:ammonia ligase (ADP-forming)]-(AMP)

Escherichia coli

-

ADP, AMP, cAMP, UTP, CTP, ITP, NAD+ cannot replace ATP

643329

-

643329

r

ATP + [L-glutamate:ammonia ligase (ADP-forming)]

diphosphate + [L-glutamate:ammonia ligase (ADP-forming)]-(AMP)

Escherichia coli

-

the site of adenylylation of the Mycobacterium tuberculosis [L-glutamate:ammonia ligase (ADP-forming)] by the Escherichia coli adenylyltransferase is Tyr406. [L-glutamate:ammonia ligase (ADP-forming)] is not adenylylated when obtained directly from Mycobacterium tuberculosis cultures that are not supplemented with glutamine. Upon the addition of glutamine to the cultures, the Mycobacterium tuberculosis enzyme becomes significantly adenylylated (about 30%)

662218

-

-

?

ATP + [L-glutamate:ammonia ligase (ADP-forming)]

diphosphate + [L-glutamate:ammonia ligase (ADP-forming)]-(AMP)

Escherichia coli B / ATCC 11303

-

ADP, AMP, cAMP, UTP, CTP, ITP, NAD+ cannot replace ATP

643329

-

643329

r

ATP + [L-glutamate:ammonia ligase (ADP-forming)]

diphosphate + [L-glutamate:ammonia ligase (ADP-forming)]-(AMP)

Escherichia coli B / ATCC 11303

-

-

643330

-

643330

r

ATP + [L-glutamate:ammonia ligase (ADP-forming)]

diphosphate + [L-glutamate:ammonia ligase (ADP-forming)]-(AMP)

Escherichia coli B / ATCC 11303

-

-

643332

-

643332

r

ATP + [L-glutamate:ammonia ligase (ADP-forming)]

diphosphate + [L-glutamate:ammonia ligase (ADP-forming)]-(AMP)

Escherichia coli YMC10

-

-

672242

-

-

?

ATP + [L-glutamate:ammonia ligase (ADP-forming)]

diphosphate + [L-glutamate:ammonia ligase (ADP-forming)]-(AMP)

Mycobacterium tuberculosis

-

-

695233

-

-

?

ATP + [L-glutamate:ammonia ligase (ADP-forming)]

diphosphate + [L-glutamate:ammonia ligase (ADP-forming)]-(AMP)

Mycobacterium tuberculosis H37Rv

-

-

695233

-

-

?

ATP + [L-glutamate:ammonia ligase (ADP-forming)]

diphosphate + [L-glutamate:ammonia ligase (ADP-forming)]-(AMP)

Mycobacterium tuberculosis variant bovis

-

-

695233

-

-

?

ATP + [L-glutamate:ammonia ligase (ADP-forming)]

diphosphate + [L-glutamate:ammonia ligase (ADP-forming)]-(AMP)

Mycobacterium tuberculosis variant bovis AF2122/97

-

-

695233

-

-

?

ATP + [L-glutamate:ammonia ligase (ADP-forming)]

diphosphate + [L-glutamate:ammonia ligase (ADP-forming)]-(AMP)

Pseudomonas putida

-

-

643333

-

643333

r

ATP + [L-glutamate:ammonia ligase (ADP-forming)]

diphosphate + [L-glutamate:ammonia ligase (ADP-forming)]-(AMP)

Rhodospirillum rubrum

-

-

687419

-

-

r

ATP + [L-glutamate:ammonia ligase (ADP-forming)]

diphosphate + [L-glutamate:ammonia ligase (ADP-forming)]-(AMP)

Salmonella enterica subsp. enterica serovar Typhimurium

-

-

643333

-

643333

r

glutamine synthase + ATP

adenylyl-[glutamine synthase] + diphosphate

Escherichia coli

-

adenylylation reaction

672243, 673595

-

-

r

glutamine synthase + ATP

adenylyl-[glutamine synthase] + diphosphate

Escherichia coli

-

adenylyltransferase reaction

672242

-

-

r

glutamine synthase + ATP

adenylyl-[glutamine synthase] + diphosphate

Escherichia coli YMC10

-

adenylyltransferase reaction

672242

-

-

r

glutamine synthase + ATP

adenylyl-[glutamine synthase] + diphosphate

Rhodospirillum rubrum

-

ATase primarily regulated by alpha-ketoglutarate, glutamine has no effect on neither the adenylylation nor the deadenylylation of glutamine synthetase, PII proteins only stimulate the adenylylation reaction

673590

-

-

r

additional information

?

-

Escherichia coli

-

enzyme also catalyzes a phosphate exchange between ATP and diphosphate, which is also stimulated by glutamine

643332

-

-

?

additional information

?

-

Escherichia coli

-

signal transduction system in nitrogen assimilation of Escherichia coli

643335

-

-

?

additional information

?

-

Escherichia coli

-

enzyme is regulated by glutamine, 2-oxoglutarate and the regulatory enzymes PII and GlnK

643335

-

-

?

additional information

?

-

Escherichia coli

-

the bifunctional adenylyltransferase ATase, product of glnE, catalyzes the adenylylation of glutamine synthetase and the deadenylylation of glutamine synthetase-AMP, reaction of EC 2.7.7.89. The adenylylation reaction is activated by PII signal transduction protein, while the deadenylylation reaction requires PII-UMP. Both of these reactions are stimulated by 2-ketoglutarate and ATP

733319

-

-

?

additional information

?

-

Escherichia coli B / ATCC 11303

-

enzyme also catalyzes a phosphate exchange between ATP and diphosphate, which is also stimulated by glutamine

643332

-

-

?