2.7.7.43: N-acylneuraminate cytidylyltransferase

This is an abbreviated version!
For detailed information about N-acylneuraminate cytidylyltransferase, go to the full flat file.

Reaction

Synonyms

AaCSS, acylneuraminate cytidyltransferase, CMAS, Cmas1, Cmas2, CMP sialate pyrophosphorylase, CMP-N-acetylneuraminate synthase, CMP-N-acetylneuraminate synthetase, CMP-N-acetylneuraminic acid synthase, CMP-N-acetylneuraminic acid synthetase, CMP-N-acylneuraminic acid synthetase, CMP-NANA synthetase, CMP-Neu5Ac synthetase, CMP-NeuAc synthetase, CMP-NeuNAc synthetase, CMP-SA synthase, CMP-Sia synthetase, CMP-Sia-syn, CMP-sialate synthase, CMP-sialate synthetase, CMP-sialic acid synthetase, CMP-sialic acid synthetase (CSS), CMP-sialic synthetase, CMPsialate pyrophosphorylase, CMPsialate synthase, CNS, CSAS, CSS, cytidine 5'-monophosphate N-acetylneuraminic acid synthetase, cytidine 5'-monophospho-N-acetylneuraminic acid synthetase, cytidine 5'-monophosphosialic acid synthetase, cytidine 5-monophosphate N-acetylneuraminic acid synthetase, cytidine monophosphate N-acetylneuraminic acid synthetase, cytidine monophosphate sialic acid synthetase, cytidine monophosphate-N-acetylneuraminic acid synthetase, cytidine monophosphate-sialic acid synthetase, cytidine monophospho-sialic acid synthetase, cytidine monophosphoacetylneuraminic synthetase, cytidine monophosphosialate pyrophosphorylase, cytidine monophosphosialate synthetase, cytidyltransferase, acylneuraminate, cytidylyltransferase, acetylneuraminate, DmCSAS, DmCSS, hCSS, mCSS, N-Acetyl-neuraminic acid cytidylyltransferase, NmCSS, SaV CSS, sialate cytidylyltransferase, sialic acid cytidylyltransferase, TcCSS

ECTree

     2 Transferases

         2.7 Transferring phosphorus-containing groups

             2.7.7 Nucleotidyltransferases

                2.7.7.43 N-acylneuraminate cytidylyltransferase

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Results	in table
13	Activating Compound
3864	AA Sequence
8	Application
1	CAS Registry Number
35	Cloned(Commentary)
4	Crystallization (Commentary)
14	Disease/ Diagnostics
1	Expression
12	General Information
9	General Stability
10	IC50 Value
100	Inhibitors
30	kcat/KM [mM/s]
2	Ki Value [mM]
129	KM Value [mM]
30	Localization
64	Metals/Ions
43	Molecular Weight [Da]
37	Natural Substrates/ Products (Substrates)
121	Organism
7	Pathway
17	PDB ID
28	pH Optimum
12	pH Range
3	pH Stability
5	pI Value
8	Posttranslational Modification
53	Protein Variants
26	Purification (Commentary)
6	Reaction
3	Reaction Type
95	Reference
65	Source Tissue
20	Specific Activity [micromol/min/mg]
13	Storage Stability
228	Substrates and Products (Substrate)
39	Subunits
139	Synonyms
1	Systematic Name
21	Temperature Optimum [°C]
6	Temperature Range [°C]
16	Temperature Stability [°C]
44	Turnover Number [1/s]

KCat KM Value

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KCat KM Value on EC 2.7.7.43 - N-acylneuraminate cytidylyltransferase

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kcat/KM VALUE [1/mMs^-1]

SUBSTRATE

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

IMAGE

0.55 - 1.3

8-O-methyl-N-acetylneuraminate

2 entries

0.0013 - 40

CTP

11 entries

0.0005 - 86

N-acetylneuraminate

11 entries

55.75

N-acylneuraminate

Vibrio cholerae

-

at pH 7.5 and 25°C

760285

1.5

N-glycolneuraminate

Vibrio cholerae

-

at pH 7.5 and 25°C

760285

-

3.8 - 5.9

N-glycolylneuraminate

2 entries

1.6 - 1.7

N-methylglycolylneuraminate

2 entries

0.55

8-O-methyl-N-acetylneuraminate

Neisseria meningitidis

-

wild-type, pH 8.5, 37°C

721380

1.3

8-O-methyl-N-acetylneuraminate

Neisseria meningitidis

-

mutant S81R, pH 8.5, 37°C

721380

0.0013

CTP

Neisseria meningitidis

P0A0Z8

mutant Y179A, pH 7.5, 22°C

722232

0.072

CTP

Neisseria meningitidis

P0A0Z8

mutant Q104A, pH 7.5, 22°C

722232

0.09

CTP

Neisseria meningitidis

P0A0Z8

mutant N175A, pH 7.5, 22°C

722232

0.097

CTP

Neisseria meningitidis

P0A0Z8

mutant F193A, pH 7.5, 22°C

722232

0.132

CTP

Neisseria meningitidis

P0A0Z8

mutant F192A, pH 7.5, 22°C

722232

0.143

CTP

Neisseria meningitidis

P0A0Z8

mutant R173A, pH 7.5, 22°C

722232

0.6

CTP

Neisseria meningitidis

P0A0Z8

wild-type, pH 7.5, 22°C

722232

19

CTP

Pasteurella multocida

-

wild-type, pH 8.5, 37°C

721380

33

CTP

[Haemophilus] ducreyi

-

wild-type, pH 8.5, 37°C

721380

36

CTP

Neisseria meningitidis

-

wild-type, pH 8.5, 37°C

721380

40

CTP

Neisseria meningitidis

-

mutant S81R, pH 8.5, 37°C

721380

0.0005

N-acetylneuraminate

Neisseria meningitidis

P0A0Z8

mutant Y179A, pH 7.5, 22°C

722232

0.0009

N-acetylneuraminate

Neisseria meningitidis

P0A0Z8

mutant Q104A, pH 7.5, 22°C

722232

0.0063

N-acetylneuraminate

Neisseria meningitidis

P0A0Z8

mutant F193A, pH 7.5, 22°C

722232

0.052

N-acetylneuraminate

Neisseria meningitidis

P0A0Z8

mutant F192A, pH 7.5, 22°C

722232

0.148

N-acetylneuraminate

Neisseria meningitidis

P0A0Z8

wild-type, pH 7.5, 22°C

722232

0.155

N-acetylneuraminate

Neisseria meningitidis

P0A0Z8

mutant N175A, pH 7.5, 22°C

722232

0.23

N-acetylneuraminate

Neisseria meningitidis

P0A0Z8

mutant R173A, pH 7.5, 22°C

722232

27

N-acetylneuraminate

[Haemophilus] ducreyi

-

wild-type, pH 8.5, 37°C

721380

30

N-acetylneuraminate

Pasteurella multocida

-

wild-type, pH 8.5, 37°C

721380

74

N-acetylneuraminate

Neisseria meningitidis

-

mutant S81R, pH 8.5, 37°C

721380

86

N-acetylneuraminate

Neisseria meningitidis

-

wild-type, pH 8.5, 37°C

721380

3.8

N-glycolylneuraminate

Neisseria meningitidis

-

wild-type, pH 8.5, 37°C

721380

5.9

N-glycolylneuraminate

Neisseria meningitidis

-

mutant S81R, pH 8.5, 37°C

721380

1.6

N-methylglycolylneuraminate

Neisseria meningitidis

-

wild-type, pH 8.5, 37°C

721380

1.7

N-methylglycolylneuraminate

Neisseria meningitidis

-

mutant S81R, pH 8.5, 37°C

721380