2.7.7.43: N-acylneuraminate cytidylyltransferase

This is an abbreviated version!
For detailed information about N-acylneuraminate cytidylyltransferase, go to the full flat file.

Word Map on EC 2.7.7.43

2.7.7.43

sialylation

sialyltransferase

meningitidis

polysialic

lipooligosaccharide

n-acetylmannosamine

ducreyi

sialoglycoconjugates

synthesis

kdn

mannac

neu5gc

medicine

agriculture

Reaction

Synonyms

AaCSS, acylneuraminate cytidyltransferase, CMAS, Cmas1, Cmas2, CMP sialate pyrophosphorylase, CMP-N-acetylneuraminate synthase, CMP-N-acetylneuraminate synthetase, CMP-N-acetylneuraminic acid synthase, CMP-N-acetylneuraminic acid synthetase, CMP-N-acylneuraminic acid synthetase, CMP-NANA synthetase, CMP-Neu5Ac synthetase, CMP-NeuAc synthetase, CMP-NeuNAc synthetase, CMP-SA synthase, CMP-Sia synthetase, CMP-Sia-syn, CMP-sialate synthase, CMP-sialate synthetase, CMP-sialic acid synthetase, CMP-sialic acid synthetase (CSS), CMP-sialic synthetase, CMPsialate pyrophosphorylase, CMPsialate synthase, CNS, CSAS, CSS, cytidine 5'-monophosphate N-acetylneuraminic acid synthetase, cytidine 5'-monophospho-N-acetylneuraminic acid synthetase, cytidine 5'-monophosphosialic acid synthetase, cytidine 5-monophosphate N-acetylneuraminic acid synthetase, cytidine monophosphate N-acetylneuraminic acid synthetase, cytidine monophosphate sialic acid synthetase, cytidine monophosphate-N-acetylneuraminic acid synthetase, cytidine monophosphate-sialic acid synthetase, cytidine monophospho-sialic acid synthetase, cytidine monophosphoacetylneuraminic synthetase, cytidine monophosphosialate pyrophosphorylase, cytidine monophosphosialate synthetase, cytidyltransferase, acylneuraminate, cytidylyltransferase, acetylneuraminate, DmCSAS, DmCSS, hCSS, mCSS, N-Acetyl-neuraminic acid cytidylyltransferase, NmCSS, SaV CSS, sialate cytidylyltransferase, sialic acid cytidylyltransferase, TcCSS

ECTree

2 Transferases

2.7 Transferring phosphorus-containing groups

2.7.7 Nucleotidyltransferases

2.7.7.43 N-acylneuraminate cytidylyltransferase

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Results	in table
13	Activating Compound
3864	AA Sequence
8	Application
1	CAS Registry Number
35	Cloned(Commentary)
4	Crystallization (Commentary)
14	Disease/ Diagnostics
1	Expression
12	General Information
9	General Stability
10	IC50 Value
100	Inhibitors
30	kcat/KM [mM/s]
2	Ki Value [mM]
129	KM Value [mM]
30	Localization
64	Metals/Ions
43	Molecular Weight [Da]
37	Natural Substrates/ Products (Substrates)
121	Organism
7	Pathway
17	PDB ID
28	pH Optimum
12	pH Range
3	pH Stability
5	pI Value
8	Posttranslational Modification
53	Protein Variants
26	Purification (Commentary)
6	Reaction
3	Reaction Type
95	Reference
65	Source Tissue
20	Specific Activity [micromol/min/mg]
13	Storage Stability
228	Substrates and Products (Substrate)
39	Subunits
139	Synonyms
1	Systematic Name
21	Temperature Optimum [°C]
6	Temperature Range [°C]
16	Temperature Stability [°C]
44	Turnover Number [1/s]

Specific Activity

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Specific Activity on EC 2.7.7.43 - N-acylneuraminate cytidylyltransferase

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0.0017

Escherichia coli

mutant enzyme DELTA1-227

0.0113

wild-type enzyme

0.045

0.165

Photobacterium leiognathi

30°C, pH 9.0

721874

0.2

Danio rerio

H9BFW7, Q0E671

substrate N-glycolylneuraminate, pH 7.5, temperature not specified in the publication

722748

0.3

Danio rerio

H9BFW7, Q0E671

substrate 5-deaminoneuraminate, pH 7.5, temperature not specified in the publication

0.354

0.542

0.83

at pH 7.6

1.58 - 3.17

at pH 9.0

12.66

[Haemophilus] ducreyi

18.25

2.1

2.7

substrate N-glycolylneuraminate, pH 7.5, temperature not specified in the publication

722748

3.3

Danio rerio

H9BFW7, Q0E671

substrate 5-deaminoneuraminate, pH 7.5, temperature not specified in the publication

722748

4.5

Danio rerio

H9BFW7, Q0E671

substrate N-acetylneuraminate, pH 7.5, temperature not specified in the publication

722748

additional information

3 entries