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2.7.7.43: N-acylneuraminate cytidylyltransferase

This is an abbreviated version!
For detailed information about N-acylneuraminate cytidylyltransferase, go to the full flat file.

Word Map on EC 2.7.7.43

Reaction

CTP
+
N-acetylneuraminate
=
diphosphate
 +
CMP-N-acylneuraminate

Synonyms

AaCSS, acylneuraminate cytidyltransferase, CMAS, Cmas1, Cmas2, CMP sialate pyrophosphorylase, CMP-N-acetylneuraminate synthase, CMP-N-acetylneuraminate synthetase, CMP-N-acetylneuraminic acid synthase, CMP-N-acetylneuraminic acid synthetase, CMP-N-acylneuraminic acid synthetase, CMP-NANA synthetase, CMP-Neu5Ac synthetase, CMP-NeuAc synthetase, CMP-NeuNAc synthetase, CMP-SA synthase, CMP-Sia synthetase, CMP-Sia-syn, CMP-sialate synthase, CMP-sialate synthetase, CMP-sialic acid synthetase, CMP-sialic acid synthetase (CSS), CMP-sialic synthetase, CMPsialate pyrophosphorylase, CMPsialate synthase, CNS, CSAS, CSS, cytidine 5'-monophosphate N-acetylneuraminic acid synthetase, cytidine 5'-monophospho-N-acetylneuraminic acid synthetase, cytidine 5'-monophosphosialic acid synthetase, cytidine 5-monophosphate N-acetylneuraminic acid synthetase, cytidine monophosphate N-acetylneuraminic acid synthetase, cytidine monophosphate sialic acid synthetase, cytidine monophosphate-N-acetylneuraminic acid synthetase, cytidine monophosphate-sialic acid synthetase, cytidine monophospho-sialic acid synthetase, cytidine monophosphoacetylneuraminic synthetase, cytidine monophosphosialate pyrophosphorylase, cytidine monophosphosialate synthetase, cytidyltransferase, acylneuraminate, cytidylyltransferase, acetylneuraminate, DmCSAS, DmCSS, hCSS, mCSS, N-Acetyl-neuraminic acid cytidylyltransferase, NmCSS, SaV CSS, sialate cytidylyltransferase, sialic acid cytidylyltransferase, TcCSS

ECTree

     2 Transferases
         2.7 Transferring phosphorus-containing groups
             2.7.7 Nucleotidyltransferases
                2.7.7.43 N-acylneuraminate cytidylyltransferase

pH Range

pH Range on EC 2.7.7.43 - N-acylneuraminate cytidylyltransferase

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pH RANGE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
6.5 - 9
the enzyme has a relatively narrow optimum around pH 8.0. In standard assay conditions, the enzyme activity declines precipitously at lower pH, dropping to 20% around pH 7.4 and becoming practically negligible below pH 7.0. The enzyme activity also declines substantially but more gradually, losing around 50% at pH 9.0. The enzyme exhibits significant activity at pH 6.5 in the presence of Mn2+, Co2+, Zn2+, Fe2+ and Ni2+
7 - 10
-
pH 7.0: about 90% of maximal activity, pH 10.0: about 70% of maximal activity
7 - 12.5
-
activity decreases dramatically below pH 7.0 and above pH 12.5
7.5 - 10.5
enzyme is active in a wide pH-range
7.5 - 9
7.5 - 9.5
-
pH 7.5: about 20% of maximal activity, pH 8.0: about 90% of maximal activity, pH 9.5: about 65% of maximal activity
8 - 13
8.5 - 9.5
-
-