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2.7.7.46: gentamicin 2''-nucleotidyltransferase

This is an abbreviated version!
For detailed information about gentamicin 2''-nucleotidyltransferase, go to the full flat file.

Word Map on EC 2.7.7.46

Reaction

nucleoside triphosphate
+
gentamicin
=
diphosphate
+
2''-nucleotidylgentamicin

Synonyms

AAD 2'', aadB, aadB(ant2')Ia, aminoglycoside adenyltransferase 2''-Ia, aminoglycoside adenylyltransferase, aminoglycoside nucleotidyltransferase 2''-I, ANT(2'')-I, ANT(2'')-Ia, ANT2'', gentamicin 2''-adenylyltransferase, gentamicin nucleotidyltransferase

ECTree

     2 Transferases
         2.7 Transferring phosphorus-containing groups
             2.7.7 Nucleotidyltransferases
                2.7.7.46 gentamicin 2''-nucleotidyltransferase

Reference

Reference on EC 2.7.7.46 - gentamicin 2''-nucleotidyltransferase

Please use the Reference Search for a specific query.
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REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Angelatou, F.; Litsas, S.B.; Kontomichalou, P.
Purification and properties of two gentamicin-modifying enzymes, coded by a single plasmid pPK237 originating from Pseudomonas aeruginosa
J. Antibiot.
35
235-244
1982
Pseudomonas aeruginosa
Manually annotated by BRENDA team
Van Pelt, J.E.; Northrop, D.B.
Purification and properties of gentamicin nucleotidyltransferase from Escherichia coli: nucleotide specificity, pH optimum, and the separation of two electrophoretic variants
Arch. Biochem. Biophys.
230
250-263
1984
Escherichia coli
Manually annotated by BRENDA team
Yagisawa, M.; Naganawa, H.; Kondo, S.; Hamada, M.; Takeuchi, T.; Umezawa, H.
Adenylyldideoxykanamycin B, a product of the inactivation of dideoxykanamycin B by Escherichia coli carrying R factor
J. Antibiot.
26
911-912
1971
Escherichia coli, Escherichia coli JR66/W677
-
Manually annotated by BRENDA team
Naganawa, H.; Yagisawa, M.; Kondo, S.; Takeuchi, T.; Umezawa, H.
The structure determination of an enzymatic inactivation product of 3',4'-dideoxykanamycin B
J. Antibiot.
26
913-914
1971
Escherichia coli, Escherichia coli JR66/W677
Manually annotated by BRENDA team
Gates, C.A.; Northrop, D.B.
Alternative substrate and inhibition kinetics of aminoglycoside nucleotidyltransferase 2''-I in support of a Theorell-Chance kinetic mechanism
Biochemistry
27
3826-3833
1988
Escherichia coli, Escherichia coli W677/pMY10
Manually annotated by BRENDA team
Gates, C.A.; Northrop, D.B.
Determination of the rate-limiting segment of aminoglycoside nucleotidyltransferase 2''-I by pH- and viscosity-dependent kinetics
Biochemistry
27
3834-3842
1988
Escherichia coli
Manually annotated by BRENDA team
Van Pelt, J.E.; Mooberry, E.S.; Frey, P.A.
1H, 13C, and 31P nuclear magnetic resonance spectral assignments for tobramycin, 2"-(adenosine-5'-phosphoryl)-tobramycin and 2"-(adenosine-5'-thiophosphoryl)-tobramycin
Arch. Biochem. Biophys.
280
284-291
1990
Escherichia coli
Manually annotated by BRENDA team
Ekman, D.R.; DiGiammarino, E.L.; Wright, E.; Witter, E.D.; Serpersu, E.H.
Cloning, overexpression, and purification of aminoglycoside antibiotic nucleotidyltransferase (2'')-Ia: conformational studies with bound substrates
Biochemistry
40
7017-7024
2001
Pseudomonas aeruginosa
Manually annotated by BRENDA team
Anderson, S.E.; Sherman, E.X.; Weiss, D.S.; Rather, P.N.
Aminoglycoside heteroresistance in Acinetobacter baumannii AB5075
mSphere
3
e00271-18
2018
Acinetobacter baumannii (B0VCJ4), Acinetobacter baumannii AB5075 (B0VCJ4)
Manually annotated by BRENDA team
Bacot-Davis, V.R.; Bassenden, A.V.; Sprules, T.; Berghuis, A.M.
Effect of solvent and protein dynamics in ligand recognition and inhibition of aminoglycoside adenyltransferase 2''-Ia
Protein Sci.
26
1852-1863
2017
Klebsiella pneumoniae (P0AE05)
Manually annotated by BRENDA team