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2.7.7.49: RNA-directed DNA polymerase

This is an abbreviated version!
For detailed information about RNA-directed DNA polymerase, go to the full flat file.

Word Map on EC 2.7.7.49

Reaction

a 2'-deoxyribonucleoside 5'-triphosphate
+
DNAn
=
diphosphate
 +
DNAn+1

Synonyms

Bst DNA polymerase, CS5 pol, DNA nucleotidyltransferase (RNA-directed), DNA polymerase, DNA polymerase I, FeLV RT, FIV RT, FV Pol, FV reverse transcriptase, Gag-Pol, HBV-pol, HIV reverse transcriptase, HIV-1 M RT, HIV-1 O RT, HIV-1 R, HIV-1 reverse transcriptase, HIV-1 RT, HIV-reverse transcriptase, HIV-RT, human hepatitis B virus polymerase, human immunodeficiency virus type 1 reverse transcriptase, iScript enzyme, K4 polymerase, K4PolI, M-MuLV reverse transcriptase, MMLV RT, Moloney Murine leukemia virus reverse transcriptase, Moloney murine leukemia virus RT, MoMLV RT, More, MuLV RT, MX162-RT, MX65-RT, nucleoside reverse transcriptase, nucleotidyltransferase, deoxyribonucleate, RNA-dependent, p66 RT, P72, PFV RT, Pol, polymerase/reverse transcriptase, prototype foamy virus reverse transcriptase, R2-RT, reverse transcriptase, reverse transcriptase/RNA dependent DNA polymerase, reverse-transcriptase, revertase, RNA dependent DNA polymerase, RNA revertase, RNA-dependent DNA polymerase, RNA-instructed DNA polymerase, RT, SFV RT, simian foamy virus reverse transcriptase, SS RT, SuperScript I reverse transcriptase, Superscript II, SUPERSCRIPT II reverse transcriptase, T. Z05 pol, telomerase, telomerase catalytic subunit, telomerase reverse transcriptase, TERT, Tgo-Pol, xenotropic murine leukemia virus-related virus reverse transcriptase, XMRV RT, XNA reverse transcriptase

ECTree

     2 Transferases
         2.7 Transferring phosphorus-containing groups
             2.7.7 Nucleotidyltransferases
                2.7.7.49 RNA-directed DNA polymerase

Turnover Number

Turnover Number on EC 2.7.7.49 - RNA-directed DNA polymerase

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TURNOVER NUMBER [1/s]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.0295 - 0.047
((2R,3S,5R)-3-hydroxy-5-(6-(prop-2-yn-1-ylamino)-9H-purin-9-yl)tetrahydrofuran-2-yl)methyl tetrahydrogen triphosphate
-
0.032 - 0.042
((2R,3S,5R)-5-(2-amino-6-(prop-2-yn-1-ylamino)-9H-purin-9-yl)-3-hydroxytetrahydrofuran-2-yl)methyl tetrahydrogen triphosphate
-
0.028 - 0.0545
((2R,3S,5R)-5-(2-amino-6-(prop-2-yn-1-yloxy)-9H-purin-9-yl)-3-hydroxytetrahydrofuran-2-yl)methyl tetrahydrogen triphosphate
-
0.0195
((2R,3S,5R)-5-(6-amino-8-(prop-2-yn-1-ylamino)-9H-purin-9-yl)-3-hydroxytetrahydrofuran-2-yl)methyl tetrahydrogen triphosphate
-
pH 8.0, 37°C, RNA template
-
0.042 - 0.16
(-)-beta-2',3'-dideoxy-3'-thiacytidine triphosphat
-
0.042 - 0.16
(-)-beta-2',3'-dideoxy-3'-thiacytidine triphosphate
0.077 - 0.67
2',3'-dideoxy-CTP
0.0265
2'-deoxyadenosine 5'-triphosphate
-
at 37°C
1.33
2'-deoxyguanosine 5'-triphosphate
-
at 37°C
0.034
2'-deoxythymidine 5'-triphosphate
-
at 37°C
0.16 - 14
3'-azido-2',3'-dideoxy-2,6-diaminopurine-beta-D-ribofuranosyl 5'-triphosphate
0.37 - 2.7
3'-azido-2',3'-dideoxy-2-amino-6-chloropurine-beta-D-ribofuranosyl 5'-triphosphate
0.22 - 2.8
3'-azido-2',3'-dideoxy-2-amino-6-methoxypurine-beta-D-ribofuranosyl 5'-triphosphate
2.1
3'-azido-2',3'-dideoxy-2-amino-6-N-allylaminopurine-beta-D-ribofuranosyl 5'-triphosphate
-
pH 7.5, 37°C, wild-type enzyme
14
3'-azido-2',3'-dideoxyadenosine triphosphate
-
pH 7.5, 37°C, wild-type enzyme
0.00075 - 17
dATP
0.000083 - 1.64
dCTP
0.0117
deoxy-5'-CTP
-
at 37°C
3 - 4
deoxynucleoside triphosphate
0.00088 - 17.3
dGTP
0.35 - 29
DNAn
0.17 - 35
dTTP
0.07
N-cyclobutyladenosine-phosphonyl diphosphate
-
pH and temperature not specified in the publication, wild-type enzyme
0.15
tenofovir diphosphate
-
pH and temperature not specified in the publication, wild-type enzyme
additional information
additional information
-