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2.7.7.50: mRNA guanylyltransferase

This is an abbreviated version!
For detailed information about mRNA guanylyltransferase, go to the full flat file.

Word Map on EC 2.7.7.50

Reaction

GTP
+
(5')ppPur-mRNA
=
diphosphate
 +
G(5')pppPur-mRNA

Synonyms

A103R, A103R protein, cap guanylyltransferase-methyltransferase, capping enzyme, capping enzyme guanylyltransferase, Ceg1, CET1, CmCeg1, D1 protein, GDP polyribonucleotidyltransferase, GlCeg1, GTase, GTP-RNA guanylyltransferase, GTP:RNA GTase, guanylyltransferase, guanylyltransferase mRNA capping, HCE, L protein, Mce1, messenger RNA guanylyltransferase, More, mRNA capping enzyme, mRNA guanylyl transferase, mRNA-cap, mRNA-capping enzyme, NAD-decapping enzyme, nsP1, NudC, PRNTase, protein lambda2, RNA capping enzyme, RNA guanylyltransferase, RNGTT, TbCgm1, TTM-type RTPase-GTase, VACWR106, VP3

ECTree

     2 Transferases
         2.7 Transferring phosphorus-containing groups
             2.7.7 Nucleotidyltransferases
                2.7.7.50 mRNA guanylyltransferase

IC50 Value

IC50 Value on EC 2.7.7.50 - mRNA guanylyltransferase

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IC50 VALUE [mM]
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
1.4
2'-fluoro-2'-deoxy-GTP
Paramecium bursaria Chlorella virus 1
IC50 value for formation of enzyme-GMP-complex, pH 7.5, 30°C
0.16
2-amino-6-chloropurine-ribose triphosphate
Paramecium bursaria Chlorella virus 1
IC50 value for formation of enzyme-GMP-complex, pH 7.5, 30°C
0.15
3'-deoxy-GTP
Paramecium bursaria Chlorella virus 1
IC50 value for formation of enzyme-GMP-complex, pH 7.5, 30°C
0.45
3'-O-Methyl-GTP
Paramecium bursaria Chlorella virus 1
IC50 value for formation of enzyme-GMP-complex, pH 7.5, 30°C
0.1557
3-[(5Z)-5-(2,3-dichlorobenzylidene)-4-oxo-2-thioxo-1,3-thiazolidin-3-yl]propanoic acid
0.0026
3-[(5Z)-5-(2,4-dichlorobenzylidene)-4-oxo-2-thioxo-1,3-thiazolidin-3-yl]propanoic acid
0.0073
3-[(5Z)-5-(4-tert-butylbenzylidene)-4-oxo-2-thioxo-1,3-thiazolidin-3-yl]propanoic acid
0.43
6-methylthio-GTP
Paramecium bursaria Chlorella virus 1
IC50 value for formation of enzyme-GMP-complex, pH 7.5, 30°C
0.22
6-thio-GTP
Paramecium bursaria Chlorella virus 1
IC50 value for formation of enzyme-GMP-complex, pH 7.5, 30°C
1.5
8-bromo-GTP
Paramecium bursaria Chlorella virus 1
IC50 value for formation of enzyme-GMP-complex, pH 7.5, 30°C
0.42
8-iodoGTP
Paramecium bursaria Chlorella virus 1
IC50 value for formation of enzyme-GMP-complex, pH 7.5, 30°C
0.1
GTP
Paramecium bursaria Chlorella virus 1
IC50 value for formation of enzyme-GMP-complex, pH 7.5, 30°C
0.34
ITP
Paramecium bursaria Chlorella virus 1
IC50 value for formation of enzyme-GMP-complex, pH 7.5, 30°C
0.08
N1-methyl-GTP
Paramecium bursaria Chlorella virus 1
IC50 value for formation of enzyme-GMP-complex, pH 7.5, 30°C
0.15
O6-methyl-GTP
Paramecium bursaria Chlorella virus 1
IC50 value for formation of enzyme-GMP-complex, pH 7.5, 30°C
0.0088
[(5Z)-4-oxo-5-(4-phenoxybenzylidene)-2-thioxo-1,3-thiazolidin-3-yl]acetic acid
0.0069
[(5Z)-5-(3,5-diiodo-2-methoxybenzylidene)-4-oxo-2-thioxo-1,3-thiazolidin-3-yl]acetic acid
0.0078
[(5Z)-5-[4-(benzyloxy)benzylidene]-4-oxo-2-thioxo-1,3-thiazolidin-3-yl]acetic acid