2.7.7.50: mRNA guanylyltransferase
This is an abbreviated version!
For detailed information about mRNA guanylyltransferase, go to the full flat file.
Word Map on EC 2.7.7.50
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2.7.7.50
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cyclin
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photosystem
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thylakoids
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photoinhibition
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chloroplast
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cyanobacterium
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chlorophyll
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synechocystis
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photodamage
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photochemical
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triphosphatase
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retinoblastoma
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cyclin-dependent
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vaccinia
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reinhardtii
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high-light
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photoprotection
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5'-triphosphatase
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qa
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mantle
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plastoquinone
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synechococcus
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oxygen-evolving
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thermoluminescence
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photoinactivation
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xanthophyl
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7-methylguanosine
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atrazine
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water-splitting
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p-tefb
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lhcii
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non-photochemical
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alpha-32pgtp
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water-oxidizing
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chloroplast-encoded
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biotechnology
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vp3
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diuron
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nsp1
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low-light
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lincomycin
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grana
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herbicide-resistant
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analysis
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psbo
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reoviridae
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cap-binding
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spt5
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photoinhibitory
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flash-induced
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uncapped
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thermosynechococcus
- 2.7.7.50
- cyclin
- photosystem
- thylakoids
-
photoinhibition
- chloroplast
- cyanobacterium
- chlorophyll
- synechocystis
-
photodamage
-
photochemical
- triphosphatase
- retinoblastoma
-
cyclin-dependent
- vaccinia
- reinhardtii
-
high-light
-
photoprotection
- 5'-triphosphatase
- qa
-
mantle
- plastoquinone
- synechococcus
-
oxygen-evolving
-
thermoluminescence
-
photoinactivation
-
xanthophyl
- 7-methylguanosine
- atrazine
-
water-splitting
- p-tefb
- lhcii
-
non-photochemical
-
alpha-32pgtp
-
water-oxidizing
-
chloroplast-encoded
- biotechnology
- vp3
- diuron
- nsp1
-
low-light
- lincomycin
-
grana
-
herbicide-resistant
- analysis
- psbo
- reoviridae
-
cap-binding
- spt5
-
photoinhibitory
-
flash-induced
-
uncapped
- thermosynechococcus
Reaction
Synonyms
A103R, A103R protein, cap guanylyltransferase-methyltransferase, capping enzyme, capping enzyme guanylyltransferase, Ceg1, CET1, CmCeg1, D1 protein, GDP polyribonucleotidyltransferase, GlCeg1, GTase, GTP-RNA guanylyltransferase, GTP:RNA GTase, guanylyltransferase, guanylyltransferase mRNA capping, HCE, L protein, Mce1, messenger RNA guanylyltransferase, More, mRNA capping enzyme, mRNA guanylyl transferase, mRNA-cap, mRNA-capping enzyme, NAD-decapping enzyme, nsP1, NudC, PRNTase, protein lambda2, RNA capping enzyme, RNA guanylyltransferase, RNGTT, TbCgm1, TTM-type RTPase-GTase, VACWR106, VP3
ECTree
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Inhibitors
Inhibitors on EC 2.7.7.50 - mRNA guanylyltransferase
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hydrogen peroxide
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inactivates the enzyme directly through irreversible oxidation of Cys126
mizoribine 5'-phosphate
compound can inhibit the formation of the RNA cap structure catalyzed by human capping enzyme. In the presence of mizoribine 5'-phosphate, the RNA 5'-triphosphatase activity appears to be relatively unaffected while the RNA guanylyltransferase activity is inhibited. Mizoribine 5'-phosphate is a non-competitive inhibitor that likely targets an allosteric site
Mn2+
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can partially replace Mg2+ in activation, inhibits in presence of Mg2+
ribavirin triphosphate
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concentration 200fold more than the GTP input, 50% inhibition
sodium phosphonoformate
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foscarnet, inhibition of the formation of the covalent intermediate at 5 mM
tetrapotassium diphosphate
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inhibition of the formation of the covalent intermediate at 5 mM
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3-[(5Z)-5-(2,3-dichlorobenzylidene)-4-oxo-2-thioxo-1,3-thiazolidin-3-yl]propanoic acid
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3-[(5Z)-5-(2,4-dichlorobenzylidene)-4-oxo-2-thioxo-1,3-thiazolidin-3-yl]propanoic acid
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compound shows significant antiviral activity in a dengue virus subgenomic replicon assay and is able to reduce the replication of infectious West Nile virus and yellow fever virus in cell culture with low toxicity
3-[(5Z)-5-(4-tert-butylbenzylidene)-4-oxo-2-thioxo-1,3-thiazolidin-3-yl]propanoic acid
compound shows significant antiviral activity in a dengue virus subgenomic replicon assay and is able to reduce the replication of infectious West Nile virus and yellow fever virus in cell culture with low toxicity
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[(5Z)-4-oxo-5-(4-phenoxybenzylidene)-2-thioxo-1,3-thiazolidin-3-yl]acetic acid
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[(5Z)-5-(3,5-diiodo-2-methoxybenzylidene)-4-oxo-2-thioxo-1,3-thiazolidin-3-yl]acetic acid
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[(5Z)-5-[4-(benzyloxy)benzylidene]-4-oxo-2-thioxo-1,3-thiazolidin-3-yl]acetic acid
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additional information
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no inhibition by S-adenosylmethionine and S-adenosylhomocysteine
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