2.7.7.52: RNA uridylyltransferase
This is an abbreviated version!
For detailed information about RNA uridylyltransferase, go to the full flat file.
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2.7.7.52
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nurses
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caregiver
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satisfaction
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dope
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doping
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semiconductor
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self-management
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optoelectronic
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self-efficacy
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sociodemographic
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therapist
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photoluminescence
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violence
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psycinfo
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interpersonal
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curriculum
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self-care
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medicine
- 2.7.7.52
-
social
- women
-
clinician
-
services
- children
-
plan
-
physician
-
fabric
-
healthcare
-
perceived
-
professionals
-
decision
-
percept
-
demographic
-
film
-
user
-
theme
-
policy
-
psychological
-
skill
-
evidence-based
-
team
-
practitioner
-
surgeon
-
nanostructures
-
decision-making
-
emotional
-
psychosocial
-
thematic
-
tunable
-
semi-structured
- nurses
-
rehabilitation
-
caregiver
-
satisfaction
-
dope
-
doping
-
stakeholder
-
semiconductor
-
self-management
-
optoelectronic
-
self-efficacy
-
sociodemographic
-
therapist
-
photoluminescence
-
violence
-
psycinfo
-
interpersonal
-
curriculum
-
self-care
- medicine
Reaction
Synonyms
3' terminal uridylyl transferase, 3'-terminal uridylyl transferase 1, At2g45620, caffeine-induced death suppressor protein 1, Cid1, GLD2, HESO1, MEAT1, mitochondrial editosome-like complex associated TUTase 1, More, RET, RET1, RET2, RNA editing TUTase, RNA silencing protein 1, Rsp1, Tailor, TbMP57 TUTase, TbTUT3, TbTUT4, terminal RNA uridylyltransferase, terminal U transferase (TUTase), terminal uridylyl transferase, terminal uridylyltransferase, terminal uridylyltransferase Tailor, TNTase CG1091, TUT, TUT1, TUT2, TUT4, TUT7, TUTase, TUTase 1, TUTase 2, TUTase 3, TUTase 4, TUTase4, TUTase6, TUTase7, U6 snRNA-specific terminal uridylyltransferase, U6-TUTase, uridylyltransferase, terminal, URT1, UTP: RNA uridylyltransferase, UTP:RNA uridylyltransferase 1, Zcchc11, ZCCHC6
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2.7.7.52 RNA uridylyltransferaseAdvanced search results
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results (Natural Substrates Products
Natural Substrates Products on EC 2.7.7.52 - RNA uridylyltransferase
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NATURAL SUBSTRATE 
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
UTP + precursor let-7 RNAn
diphosphate + precursor let-7 RNAn+1
the interaction between the Lin28:pre-let-7 complex and the N-terminal Lin28-interacting module of TUT4 is required for prelet-7 oligo-uridylylation by the C-terminal catalytic module of TUT4/7
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?
UTP + U6 snRNAn
diphosphate + U6 snRNAn+1
the enzyme builds or repairs the 3'-oligo-uridylylated tail of U6 snRNA
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?
UTP + mRNAn
diphosphate + mRNAn+1
for mRNA, URT1 is the main enzyme to uridylate the majority of mRNA and repairs their deadenylated ends to restore the binding site for poly(A) binding protein. Enzyme HESO1, on the other hand, targets mostly the mRNAs with very short oligo(A) tails and fails in fulfilling the same task
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?
UTP + RNAn
diphosphate + RNAn+1
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responsible for post-transcriptional RNA editing process of mitochondrial transcripts in kinetoplastid protozoans
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?
UTP + RNAn
diphosphate + RNAn+1
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addition of non-coded poly(U) tail to gRNAs
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?
UTP + RNAn
diphosphate + RNAn+1
the enzyme exhibits an intrinsic preference for RNA substrates ending in 3'G
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?
UTP + RNAn
diphosphate + RNAn+1
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acts as a host factor to initiate RNA synthesis by poliovirus RNA polymerase in vitro
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?
UTP + RNAn
diphosphate + RNAn+1
the enzyme mediates template-independent uridylylation at the 3'-end of RNAs
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?
UTP + RNAn
diphosphate + RNAn+1
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involved in uridine insertion in the editing process of RNA
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?
UTP + RNAn
diphosphate + RNAn+1
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responsible for post-transcriptional RNA editing process of mitochondrial transcripts in kinetoplastid protozoans
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?
UTP + RNAn
diphosphate + RNAn+1
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addition of non-coded poly(U) tail to gRNAs
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?
UTP + RNAn
diphosphate + RNAn+1
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addition of non-coded poly(U) tail to gRNAs
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?
UTP + RNAn
diphosphate + RNAn+1
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addition of primarily single U to single-stranded RNA, addition of the number of Us specified by a guide RNA to insertion editing-like substrates
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?
UTP + RNAn
diphosphate + RNAn+1
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RNA uridylyltransferase might function in uridylating specific proteins, RNA is not a natural substrate
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?
additional information
?
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enzyme interacts with a minor fraction of total RNA ligase
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?
additional information
?
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post-transcriptional uridylylation of guide RNAs by RNA editing TUTase 1 or RET1, a multi-functional RNA processing enzyme, and U-insertion mRNA editing by RNA editing TUTase 2 or RET2, biological functions of TUT isozymes, RNA processing in mitochondria of trypanosomes, detailed overview
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?
additional information
?
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reduction of isozyme RET1 leads to decrease in edited RNA and inhibited growth, lowers the uridine insertion and leads predominantly to shorter gRNAs
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?
additional information
?
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down-regulation of isozyme RET2 inhibits growth and in vivo uridine insertion, but has no effect on the length of gRNAs
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?
additional information
?
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many editing changes are developmentally regulated
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?
additional information
?
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down-regulation of RET1, but not of RET2, affects length distribution of gRNA 3' oligo(U) tails
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?
additional information
?
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Inhibition of RNA editing by down-regulation of expression of the mitochondrial RNA editing TUTase 1 by RNA interference has profound effects on kinetoplast biogenesis in Trypanosoma brucei procyclic cells. De novo synthesis of the apocytochrome b and cytochrome oxidase subunit I proteins is no longer detectable after 3 days of RNAi. The effect on protein synthesis correlates with a decline in the levels of the assembled mitochondrial respiratory complexes III and IV, and also with cyanide-sensitive oxygen uptake. The steady-state levels of nuclear-encoded subunits of complexes III and IV are also significantly decreased. Because the levels of the corresponding mRNAs are not affected, the observed effect is likely due to an increased turnover of these imported mitochondrial proteins. This induced protein degradation is selective for components of complexes III and IV, because little effect is observed on components of the F1-F0 -ATPase complex and on several other mitochondrial proteins
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?
additional information
?
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post-transcriptional uridylylation of guide RNAs by RNA editing TUTase 1 or RET1, a multi-functional RNA processing enzyme, and U-insertion mRNA editing by RNA editing TUTase 2 or RET2, biological functions of TUT isozymes, RNA processing in mitochondria of trypanosomes, detailed overview
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?
