2.7.7.B21: N-acetylglucosamine 1-phosphate thymidylyltransferase

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For detailed information about N-acetylglucosamine 1-phosphate thymidylyltransferase, go to the full flat file.

Reaction

Synonyms

ST0452

ECTree

     2 Transferases

         2.7 Transferring phosphorus-containing groups

             2.7.7 Nucleotidyltransferases

                2.7.7.B21 N-acetylglucosamine 1-phosphate thymidylyltransferase

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Results	in table
1	AA Sequence
1	Cloned(Commentary)
6	Organism
1	pH Optimum
1	Purification (Commentary)
1	Reaction
2	Reference
1	Specific Activity [micromol/min/mg]
1	Substrates and Products (Substrate)
1	Synonyms
1	Systematic Name
1	Temperature Optimum [°C]

Substrates Products

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Substrates Products on EC 2.7.7.B21 - N-acetylglucosamine 1-phosphate thymidylyltransferase

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SUBSTRATE

PRODUCT                       

REACTION DIAGRAM

ORGANISM

UNIPROT

COMMENTARY
(Substrate)

LITERATURE
(Substrate)

COMMENTARY
(Product)

LITERATURE
(Product)

Reversibility
r=reversible
ir=irreversible
?=not specified

dTTP + N-acetyl-alpha-D-glucosamine 1-phosphate

diphosphate + dTDP-N-acetyl-alpha-D-glucosamine

Sulfurisphaera tokodaii

Q975F9

maximal velocity of the reverse reaction is 11.4fold of the maximal velocity of the forward reaction. The multifunctional enzyme also shows activity with UTP + alpha-D-glucose 1-phosphate (EC 2.7.7.9, UTP-glucose-1-phosphate uridylyltransferase), UTP + N-acetylglucosamine 1-phosphate (EC 2.7.7.23, UDP-N-acetylglucosamine diphosphorylase), dTTP + alpha-D-glucose 1-phosphate (EC 2.7.7.24, glucose-1-phosphate thymidylyltransferase), dCTP + alpha-D-glucose 1-phosphate (glucose-1-phosphate cytidylyltransferase), dGTP + alpha-D-glucose 1-phosphate (glucose-1-phosphate guanylyltransferase), dATP + alpha-D-glucose 1-phosphate (glucose-1-phosphate adenylyltransferase). No activity with: alpha-D-glucose 1-phosphate + dATP, alpha-D-glucose 1-phosphate + dCTP, alpha-D-glucose 1-phosphate + dGTP, UTP + alpha-D-mannose1-phosphate, UTP + alpha-D-galactose 1-phosphate, UTP + alpha-D-glucosamine 1-phosphate

662454

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