Information on EC 1.1.1.125 - 2-deoxy-D-gluconate 3-dehydrogenase

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The enzyme appears in viruses and cellular organisms

EC NUMBER
COMMENTARY hide
1.1.1.125
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RECOMMENDED NAME
GeneOntology No.
2-deoxy-D-gluconate 3-dehydrogenase
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
2-deoxy-D-gluconate + NAD+ = 3-dehydro-2-deoxy-D-gluconate + NADH + H+
show the reaction diagram
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REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
oxidation
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-
-
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redox reaction
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-
-
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reduction
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-
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PATHWAY
BRENDA Link
KEGG Link
MetaCyc Link
Pentose and glucuronate interconversions
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SYSTEMATIC NAME
IUBMB Comments
2-deoxy-D-gluconate:NAD+ 3-oxidoreductase
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CAS REGISTRY NUMBER
COMMENTARY hide
37250-54-7
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ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
-
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Manually annotated by BRENDA team
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Manually annotated by BRENDA team
GENERAL INFORMATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
malfunction
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when grown in the presence of galacturonate or glucuronate, kduID deficient Escherichia coli have a 30% to 80% lower maximal cell density and 1.5 to 2fold longer doubling times under osmotic stress conditions than wild type Escherichia coli
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
2-deoxy-D-gluconate + NAD+
3-dehydro-2-deoxy-D-gluconate + NADH
show the reaction diagram
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-
-
?
NATURAL SUBSTRATES
NATURAL PRODUCTS
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
2-deoxy-D-gluconate + NAD+
3-dehydro-2-deoxy-D-gluconate + NADH
show the reaction diagram
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-
-
?
COFACTOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
NAD+
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can not be replaced by NADP+
INHIBITORS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
NAD+
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inhibition at high concentrations
ACTIVATING COMPOUND
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
FMN
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stimulatory effect
KM VALUE [mM]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
1.54 - 5
2-deoxy-D-gluconate
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SPECIFIC ACTIVITY [µmol/min/mg]
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
pH OPTIMUM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
7.9 - 8.9
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SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE
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inducible enzyme synthesis by growth in 2-deoxy-D-gluconate containing medium
Manually annotated by BRENDA team
PDB
SCOP
CATH
ORGANISM
UNIPROT
Beutenbergia cavernae (strain ATCC BAA-8 / DSM 12333 / NBRC 16432)
Thermus thermophilus (strain HB8 / ATCC 27634 / DSM 579)
Thermus thermophilus (strain HB8 / ATCC 27634 / DSM 579)
Thermus thermophilus (strain HB8 / ATCC 27634 / DSM 579)
STORAGE STABILITY
ORGANISM
UNIPROT
LITERATURE
-5°C, 10 days
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Purification/COMMENTARY
ORGANISM
UNIPROT
LITERATURE
EXPRESSION
ORGANISM
UNIPROT
LITERATURE
galacturonate and glucuronate induced kduD and kduI gene expression 3fold and 7 to 11fold, respectively, under aerobic conditions as well as 9 to 20fold and 19 to 54fold, respectively, under anaerobic conditions
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