Information on EC 1.1.1.143 - sequoyitol dehydrogenase

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The expected taxonomic range for this enzyme is: Trifolium incarnatum

EC NUMBER
COMMENTARY hide
1.1.1.143
-
RECOMMENDED NAME
GeneOntology No.
sequoyitol dehydrogenase
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
5-O-methyl-myo-inositol + NAD+ = 2D-5-O-methyl-2,3,5/4,6-pentahydroxycyclohexanone + NADH + H+
show the reaction diagram
-
-
-
-
REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
oxidation
-
-
-
-
redox reaction
-
-
-
-
reduction
-
-
-
-
PATHWAY
BRENDA Link
KEGG Link
MetaCyc Link
pinitol biosynthesis II
-
-
SYSTEMATIC NAME
IUBMB Comments
5-O-methyl-myo-inositol:NAD+ oxidoreductase
-
CAS REGISTRY NUMBER
COMMENTARY hide
37250-72-9
-
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
2,4,6/3,5-pentahydroxycyclohexanone + NADH
? + NAD+
show the reaction diagram
-
-
-
?
5-O-methyl-myo-inositol + NAD+
5D-5-O-methyl-2,3,5/4,6-pentahydroxycyclohexanone + NADH
show the reaction diagram
-
B-specificity
-
r
DL-2,3,4,6/5-pentahydroxycyclohexanone + NADH
? + NAD+
show the reaction diagram
-
low activity
-
?
NATURAL SUBSTRATES
NATURAL PRODUCTS
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
5-O-methyl-myo-inositol + NAD+
5D-5-O-methyl-2,3,5/4,6-pentahydroxycyclohexanone + NADH
show the reaction diagram
-
B-specificity
-
r
COFACTOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
INHIBITORS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
iodoacetate
-
85% inhibition at 1 mM
p-chloromercuribenzoate
-
complete inhibition at 1 mM
Phenylmercurinitrate
-
complete inhibition at 1 mM
ACTIVATING COMPOUND
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
DTT
-
5fold activation
GSH
-
5fold activation
L-cysteine
-
5fold activation at 1.3 mM
pH OPTIMUM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE
-
prior to the formation of flowers
Manually annotated by BRENDA team
MOLECULAR WEIGHT
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
34000
-
gel filtration
GENERAL STABILITY
ORGANISM
UNIPROT
LITERATURE
very unstable
-
Purification/COMMENTARY
ORGANISM
UNIPROT
LITERATURE