Information on EC 1.1.1.152 - 3alpha-hydroxy-5beta-androstane-17-one 3alpha-dehydrogenase

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The expected taxonomic range for this enzyme is: Comamonas testosteroni

EC NUMBER
COMMENTARY hide
1.1.1.152
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RECOMMENDED NAME
GeneOntology No.
3alpha-hydroxy-5beta-androstane-17-one 3alpha-dehydrogenase
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
3alpha-hydroxy-5beta-androstane-17-one + NAD+ = 5beta-androstane-3,17-dione + NADH + H+
show the reaction diagram
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-
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REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
oxidation
-
-
-
-
redox reaction
-
-
-
-
reduction
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-
-
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PATHWAY
BRENDA Link
KEGG Link
MetaCyc Link
Steroid hormone biosynthesis
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-
SYSTEMATIC NAME
IUBMB Comments
3alpha-hydroxy-5beta-steroid:NAD+ 3-oxidoreductase
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CAS REGISTRY NUMBER
COMMENTARY hide
37250-77-4
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ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
2 strains, ATCC 11996 and STDH-m
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Manually annotated by BRENDA team
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
3alpha-hydroxy-5beta-androstane-17-one + NAD+
5beta-androstane-3,17-dione + NADH
show the reaction diagram
-
etiocholanolone, strong substrate specificity
-
ir
NATURAL SUBSTRATES
NATURAL PRODUCTS
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
3alpha-hydroxy-5beta-androstane-17-one + NAD+
5beta-androstane-3,17-dione + NADH
show the reaction diagram
-
etiocholanolone, strong substrate specificity
-
ir
COFACTOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE
MOLECULAR WEIGHT
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
47000
-
meniscus depletion method, gel filtration
Purification/COMMENTARY
ORGANISM
UNIPROT
LITERATURE
to homogeneity, chromatography techniques, preparative gel electrophoresis
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APPLICATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
analysis
-
selective microquantitation of steroid substrates