Information on EC 1.1.1.194 - coniferyl-alcohol dehydrogenase

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The expected taxonomic range for this enzyme is: Eukaryota, Bacteria

EC NUMBER
COMMENTARY hide
1.1.1.194
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RECOMMENDED NAME
GeneOntology No.
coniferyl-alcohol dehydrogenase
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
coniferyl alcohol + NADP+ = coniferyl aldehyde + NADPH + H+
show the reaction diagram
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REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
oxidation
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redox reaction
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reduction
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PATHWAY
BRENDA Link
KEGG Link
MetaCyc Link
capsiconiate biosynthesis
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phenylpropanoid biosynthesis
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SYSTEMATIC NAME
IUBMB Comments
coniferyl-alcohol:NADP+ oxidoreductase
Specific for coniferyl alcohol; does not act on cinnamyl alcohol, 4-coumaryl alcohol or sinapyl alcohol.
CAS REGISTRY NUMBER
COMMENTARY hide
37250-27-4
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ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
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Manually annotated by BRENDA team
L. var. Mandarin
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Manually annotated by BRENDA team
L. deepwater rice
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Manually annotated by BRENDA team
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Manually annotated by BRENDA team
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Manually annotated by BRENDA team
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Manually annotated by BRENDA team
strain HR199, gene calA
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Manually annotated by BRENDA team
strain HR199, gene calA
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Manually annotated by BRENDA team
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Manually annotated by BRENDA team
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Manually annotated by BRENDA team
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Manually annotated by BRENDA team
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
coniferyl alcohol + NADP+
coniferyl aldehyde + NADPH + H+
show the reaction diagram
NATURAL SUBSTRATES
NATURAL PRODUCTS
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
coniferyl alcohol + NADP+
coniferyl aldehyde + NADPH + H+
show the reaction diagram
COFACTOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
NADPH
additional information
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KM VALUE [mM]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.83
coniferyl alcohol
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0.0074
NADP+
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SPECIFIC ACTIVITY [µmol/min/mg]
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
0.36
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pH OPTIMUM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
TEMPERATURE OPTIMUM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
25
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assay at
SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE
MOLECULAR WEIGHT
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
43000
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gel filtration
STORAGE STABILITY
ORGANISM
UNIPROT
LITERATURE
-20°C, 42 mM 2-mercaptoethanol, 10% ethyleneglycol, several weeks
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Purification/COMMENTARY
ORGANISM
UNIPROT
LITERATURE
var. Mandarin
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Cloned/COMMENTARY
ORGANISM
UNIPROT
LITERATURE
gene calA, co-expression of the enzyme from strain HR199 with Rhodococcus sp.strain HR199 coniferyl aldehyde dehydrogenase, and Penicillium simplicissimus strain CBS vanillyl alcohol oxidase in the deficient Rhodococcus opacus strain PD630, subcloning in Escherichia coli srain XL 1-Blue
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APPLICATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
biotechnology
nutrition
synthesis