Information on EC 1.1.1.220 - 6-pyruvoyltetrahydropterin 2'-reductase

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The enzyme appears in viruses and cellular organisms

EC NUMBER
COMMENTARY hide
1.1.1.220
-
RECOMMENDED NAME
GeneOntology No.
6-pyruvoyltetrahydropterin 2'-reductase
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
6-lactoyl-5,6,7,8-tetrahydropterin + NADP+ = 6-pyruvoyltetrahydropterin + NADPH + H+
show the reaction diagram
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-
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REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
oxidation
-
-
-
-
redox reaction
-
-
-
-
reduction
-
-
-
-
PATHWAY
BRENDA Link
KEGG Link
MetaCyc Link
tetrahydrobiopterin biosynthesis II
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-
Folate biosynthesis
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Metabolic pathways
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SYSTEMATIC NAME
IUBMB Comments
6-lactoyl-5,6,7,8-tetrahydropterin:NADP+ 2'-oxidoreductase
Not identical with EC 1.1.1.153 sepiapterin reductase.
CAS REGISTRY NUMBER
COMMENTARY hide
97089-79-7
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ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
bovine
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-
Manually annotated by BRENDA team
enzyme is identical to aldose reductase
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-
Manually annotated by BRENDA team
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
4-nitrobenzaldehyde + NADPH
4-nitrobenzylalcohol + NADP+
show the reaction diagram
6-pyruvoyltetrahydropterin + NADPH
6-lactoyl-5,6,7,8-tetrahydropterin + NADP+
show the reaction diagram
menadione + NADPH
?
show the reaction diagram
-
-
-
-
?
Phenanthrenequinone + NADPH
?
show the reaction diagram
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-
-
-
?
additional information
?
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typical substrates of aldose reductase tested as substrates
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NATURAL SUBSTRATES
NATURAL PRODUCTS
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
6-pyruvoyltetrahydropterin + NADPH
6-lactoyl-5,6,7,8-tetrahydropterin + NADP+
show the reaction diagram
COFACTOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
KM VALUE [mM]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.1
4-Nitrobenzaldehyde
-
-
0.001
6-pyruvoyltetrahydropterin
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-
SPECIFIC ACTIVITY [µmol/min/mg]
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
0.0000159
-
-
0.000021
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liver
0.0000514
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brain
22
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crude extract
49300
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purified enzyme
SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE
MOLECULAR WEIGHT
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
37000
-
SDS-PAGE, gel filtration
SUBUNITS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
monomer
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SDS-PAGE, gel filtration
Purification/COMMENTARY
ORGANISM
UNIPROT
LITERATURE