Information on EC 1.1.1.232 - 15-hydroxyicosatetraenoate dehydrogenase

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The expected taxonomic range for this enzyme is: Mus musculus

EC NUMBER
COMMENTARY hide
1.1.1.232
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RECOMMENDED NAME
GeneOntology No.
15-hydroxyicosatetraenoate dehydrogenase
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
(15S)-15-hydroxy-5,8,11-cis-13-trans-icosatetraenoate + NAD(P)+ = 15-oxo-5,8,11-cis-13-trans-icosatetraenoate + NAD(P)H + H+
show the reaction diagram
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REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
oxidation
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-
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redox reaction
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-
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reduction
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PATHWAY
BRENDA Link
KEGG Link
MetaCyc Link
arachidonic acid metabolism
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Arachidonic acid metabolism
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SYSTEMATIC NAME
IUBMB Comments
(15S)-15-hydroxy-5,8,11-cis-13-trans-icosatetraenoate:NAD(P)+ 15-oxidoreductase
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CAS REGISTRY NUMBER
COMMENTARY hide
117910-46-0
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ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
-
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Manually annotated by BRENDA team
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
(15S)-15-hydroxy-5,8,11-cis-13-trans-eicosatetraenoate + NAD(P)+
15-oxo-5,8,11-cis-13-trans-eicosatetraenoate + NAD(P)H
show the reaction diagram
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COFACTOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
NAD+
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almost the same reaction rates with NAD+ and NADP+
NADP+
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almost the same reaction rates with NAD+ and NADP+
KM VALUE [mM]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.0083
(15S)-15-hydroxy-5,8,11-cis-13-trans-eicosatetraenoic acid
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0.06
NAD+
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pH OPTIMUM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
pH RANGE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
7.6 - 11.2
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SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE
LOCALIZATION
ORGANISM
UNIPROT
COMMENTARY hide
GeneOntology No.
LITERATURE
SOURCE
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tightly bound to membranes
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Manually annotated by BRENDA team
STORAGE STABILITY
ORGANISM
UNIPROT
LITERATURE
4°C enzyme in microsomal fraction very stable, cytosolic and mitochondrial fractions more than 90% loss of activity within 1 day
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