Information on EC 1.1.1.235 - 8-oxocoformycin reductase

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The expected taxonomic range for this enzyme is: Streptomyces antibioticus

EC NUMBER
COMMENTARY hide
1.1.1.235
-
RECOMMENDED NAME
GeneOntology No.
8-oxocoformycin reductase
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
coformycin + NADP+ = 8-oxocoformycin + NADPH + H+
show the reaction diagram
REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
oxidation
-
-
-
-
redox reaction
-
-
-
-
reduction
-
-
-
-
SYSTEMATIC NAME
IUBMB Comments
coformycin:NADP+ 8-oxidoreductase
Si-specific with respect to NADPH. Also reduces 8-oxodeoxy-coformycin to the nucleoside antibiotic deoxycoformycin.
CAS REGISTRY NUMBER
COMMENTARY hide
114995-16-3
-
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
8-ketocoformycin + NADPH
coformycin + NADP+
show the reaction diagram
8-ketodeoxycoformycin + NADPH
2'-deoxycoformycin + NADP+
show the reaction diagram
NATURAL SUBSTRATES
NATURAL PRODUCTS
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
8-ketocoformycin + NADPH
coformycin + NADP+
show the reaction diagram
-
production of the antibiotic coformycin
-
r
8-ketodeoxycoformycin + NADPH
2'-deoxycoformycin + NADP+
show the reaction diagram
-
production of the antibiotic 2'-deoxycoformycin
-
r
COFACTOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
NADH
-
NADPH is 25-fold higher active than NADH
NADPH
-
B-specific with respect to NADPH, 25-fold higher activity than with NADH
KM VALUE [mM]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.15
8-Ketocoformycin
-
-
0.25
8-Ketodeoxycoformycin
-
-
pH OPTIMUM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
TEMPERATURE OPTIMUM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
TEMPERATURE RANGE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
Purification/COMMENTARY
ORGANISM
UNIPROT
LITERATURE