Information on EC 1.1.1.361 - glucose-6-phosphate 3-dehydrogenase

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The expected taxonomic range for this enzyme is: Bacillus subtilis

EC NUMBER
COMMENTARY hide
1.1.1.361
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RECOMMENDED NAME
GeneOntology No.
glucose-6-phosphate 3-dehydrogenase
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REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
D-glucose 6-phosphate + NAD+ = 3-dehydro-D-glucose 6-phosphate + NADH + H+
show the reaction diagram
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PATHWAY
BRENDA Link
KEGG Link
MetaCyc Link
kanosamine biosynthesis II
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SYSTEMATIC NAME
IUBMB Comments
D-glucose-6-phosphate:NAD+ oxidoreductase
The enzyme, found in the bacterium Bacillus subtilis, is involved in a kanosamine biosynthesis pathway.
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
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Manually annotated by BRENDA team
GENERAL INFORMATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
physiological function
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the ntd operon is essential for biosynthesis of the unusual disaccharide 3,3'-neotrehalosadiamine. The enzymes catalyze the biosynthesis of kanosamine from D-glucose 6-phosphate. NtdC is a D-glucose-6-phosphate-3-dehydrogenase, NtdA is a pyridoxal phosphate-dependent 3-oxo-glucose-6-phosphate:glutamate aminotransferase, and NtdB is a kanosamine-6-phosphate phosphatase
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
D-glucose + NAD+
3-dehydro-D-glucose + NADH + H+
show the reaction diagram
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poor substrate
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?
D-glucose 6-phosphate + NAD+
3-dehydro-D-glucose 6-phosphate + NADH + H+
show the reaction diagram
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?
inositol + NAD+
? + NADH + H+
show the reaction diagram
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poor substrate
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?
additional information
?
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no substrate: UDP-glucose
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COFACTOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
NAD+
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highly specific
additional information
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no cofactor: NADP+
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Cloned/COMMENTARY
ORGANISM
UNIPROT
LITERATURE
expression in Escherichia coli
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