Information on EC 1.1.1.362 - aklaviketone reductase

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The expected taxonomic range for this enzyme is: Streptomyces sp.

EC NUMBER
COMMENTARY hide
1.1.1.362
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RECOMMENDED NAME
GeneOntology No.
aklaviketone reductase
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REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
aklavinone + NADP+ = aklaviketone + NADPH + H+
show the reaction diagram
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PATHWAY
BRENDA Link
KEGG Link
MetaCyc Link
aclacinomycin biosynthesis
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daunorubicin biosynthesis
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Biosynthesis of type II polyketide products
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Biosynthesis of antibiotics
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SYSTEMATIC NAME
IUBMB Comments
aklavinone:NADP+ oxidoreductase
The enzyme is involved in the synthesis of the aklavinone aglycone, a common precursor for several anthracycline antibiotics including aclacinomycins, daunorubicin and doxorubicin. The enzyme from the Gram-negative bacterium Streptomyces sp. C5 produces daunomycin.
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
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UniProt
Manually annotated by BRENDA team
GENERAL INFORMATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
physiological function
the enzyme is involved in the biosynthesis of the anthracyclins aclacinomycin and daunomycin
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
7-oxodaunomycinone + NADPH + H+
daunomycinone + NADP+
show the reaction diagram
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?
aklaviketone + NADPH + H+
aklavinone + NADP+
show the reaction diagram
maggiemycin + NADPH + H+
epsilon-rhodomycinone + NADP+
show the reaction diagram
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?
NATURAL SUBSTRATES
NATURAL PRODUCTS
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
aklaviketone + NADPH + H+
aklavinone + NADP+
show the reaction diagram
Q53882
the enzyme is involved in the biosynthesis of the anthracyclins aclacinomycin and daunomycin. Aklavinone is the last intermediate common to both aclacinomycin and daunomycin biosynthesis
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COFACTOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
NADPH
activity with NADH is 7% of the activity with NADPH
SUBUNITS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
?
x * 25632, calculated from sequence
Cloned/COMMENTARY
ORGANISM
UNIPROT
LITERATURE
extracts of Streptomyces lividans TK24 containing recombinant DauE catalyzes the NADPH-specific conversion of aklaviketone, maggiemycin, and 7-oxodaunomycinone to aklavinone, epsilon-rhodomycinone, and daunomycinone, respectively