Information on EC 1.1.1.372 - D/L-glyceraldehyde reductase

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The enzyme appears in viruses and cellular organisms

EC NUMBER
COMMENTARY hide
1.1.1.372
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RECOMMENDED NAME
GeneOntology No.
D/L-glyceraldehyde reductase
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REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
glycerol + NADP+ = D-glyceraldehyde + NADPH + H+
show the reaction diagram
(2)
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glycerol + NADP+ = L-glyceraldehyde + NADPH + H+
show the reaction diagram
(1)
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PATHWAY
BRENDA Link
KEGG Link
MetaCyc Link
D-galacturonate degradation III
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degradation of sugar acids
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Pentose and glucuronate interconversions
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Metabolic pathways
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SYSTEMATIC NAME
IUBMB Comments
glycerol:NADP+ oxidoreductase (D/L-glyceraldehyde-forming)
The enzyme takes part in a D-galacturonate degradation pathway in the fungi Aspergillus niger and Trichoderma reesei (Hypocrea jecorina). It has equal activity with D- and L-glyceraldehyde, and can also reduce glyoxal and methylglyoxal. The reaction is only observed in the direction of glyceraldehyde reduction.
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
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Manually annotated by BRENDA team
synonym Trichoderma reesei
UniProt
Manually annotated by BRENDA team
synonym Trichoderma reesei
UniProt
Manually annotated by BRENDA team
GENERAL INFORMATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
metabolism
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
D-glyceraldehyde + NADPH + H+
glycerol + NADP+
show the reaction diagram
diacetyl + NADPH + H+
?
show the reaction diagram
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-
?
dihydroxyacetone + NADPH + H+
?
show the reaction diagram
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?
glyoxal + NADPH + H+
?
show the reaction diagram
L-glyceraldehyde + NADPH + H+
glycerol + NADP+
show the reaction diagram
methylglyoxal + NADPH + H+
?
show the reaction diagram
additional information
?
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NATURAL SUBSTRATES
NATURAL PRODUCTS
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
D-glyceraldehyde + NADPH + H+
glycerol + NADP+
show the reaction diagram
L-glyceraldehyde + NADPH + H+
glycerol + NADP+
show the reaction diagram
additional information
?
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COFACTOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
NADPH
KM VALUE [mM]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.9
D-glyceraldehyde
5.8
dihydroxyacetone
at pH 7.0 and 30C
2.4
Glyoxal
at pH 7.0 and 30C
0.9
L-Glyceraldehyde
at pH 7.0 and 30C
0.4
methylglyoxal
at pH 7.0 and 30C
SUBUNITS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
Purification/COMMENTARY
ORGANISM
UNIPROT
LITERATURE
Ni-NTA column chromatography
Cloned/COMMENTARY
ORGANISM
UNIPROT
LITERATURE
expressed in Saccharomyces cerevisiae