Information on EC 1.1.1.386 - ipsdienol dehydrogenase

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The expected taxonomic range for this enzyme is: Ips pini

EC NUMBER
COMMENTARY hide
1.1.1.386
-
RECOMMENDED NAME
GeneOntology No.
ipsdienol dehydrogenase
-
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
(R)-ipsdienol + NAD(P)+ = ipsdienone + NAD(P)H + H+
show the reaction diagram
-
-
-
-
PATHWAY
BRENDA Link
KEGG Link
MetaCyc Link
Monoterpenoid biosynthesis
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-
SYSTEMATIC NAME
IUBMB Comments
(R)-ipsdienol:NAD(P)+ oxidoreductase
The enzyme is involved in pheromone production by the pine engraver beetle, Ips pini.
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
-
UniProt
Manually annotated by BRENDA team
GENERAL INFORMATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
metabolism
the enzyme is involved in pheromon production
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
(4R)-ipsdienol + NAD(P)+
ipsdienone + NAD(P)H + H+
show the reaction diagram
the enzyme is involved in pheromon production
-
-
?
(4R)-ipsdienol + NAD+
ipsdienone + NADH + H+
show the reaction diagram
no activity with (4S)-ipsdienol. The enzyme shows similar specific activities with NAD+ and NADP+
-
-
?
(4R)-ipsdienol + NADP+
ipsdienone + NADPH + H+
show the reaction diagram
no activity with (4S)-ipsdienol. The enzyme shows similar specific activities with NAD+ and NADP+
-
-
?
NATURAL SUBSTRATES
NATURAL PRODUCTS
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
(4R)-ipsdienol + NAD(P)+
ipsdienone + NAD(P)H + H+
show the reaction diagram
G5DGA8
the enzyme is involved in pheromon production
-
-
?
COFACTOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
NAD+
the enzyme shows similar specific activities with NAD+ and NADP+
NADP+
the enzyme shows similar specific activities with NAD+ and NADP+
KM VALUE [mM]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.58
(4R)-ipsdienol
pH 7.8, 25°C
SPECIFIC ACTIVITY [µmol/min/mg]
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
0.0163
pH 7.8, 25°C
pH OPTIMUM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
7.8
assay at
TEMPERATURE OPTIMUM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
25
assay at
pI VALUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
5.8
calculated from sequence
SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE
transcript levels are highest in pheromone producing tissue: the anterior midgut of fed males. The protein is detected only in male midguts
Manually annotated by BRENDA team
LOCALIZATION
ORGANISM
UNIPROT
COMMENTARY hide
GeneOntology No.
LITERATURE
SOURCE
MOLECULAR WEIGHT
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
28000
calculated from sequence
Cloned/COMMENTARY
ORGANISM
UNIPROT
LITERATURE
the recombinant enzyme is produced in Sf9 cells using a baculovirus expression system