Information on EC 1.1.1.66 - omega-hydroxydecanoate dehydrogenase

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The enzyme appears in viruses and cellular organisms

EC NUMBER
COMMENTARY hide
1.1.1.66
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RECOMMENDED NAME
GeneOntology No.
omega-hydroxydecanoate dehydrogenase
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
10-hydroxydecanoate + NAD+ = 10-oxodecanoate + NADH + H+
show the reaction diagram
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REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
redox reaction
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-
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SYSTEMATIC NAME
IUBMB Comments
10-hydroxydecanoate:NAD+ 10-oxidoreductase
Also acts, more slowly, on 9-hydroxynonanoate and 11-hydroxyundecanoate.
CAS REGISTRY NUMBER
COMMENTARY hide
9028-65-3
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ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
-
-
-
Manually annotated by BRENDA team
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-
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Manually annotated by BRENDA team
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-
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Manually annotated by BRENDA team
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-
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Manually annotated by BRENDA team
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
10-hydroxydecanoate + NAD+
10-oxodecanoate + NADH
show the reaction diagram
11-hydroxyundecanoate + NAD+
11-oxoundecanoate + NADH
show the reaction diagram
9-hydroxynonanoate + NAD+
9-oxononanoate + NADH
show the reaction diagram
additional information
?
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COFACTOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
KM VALUE [mM]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.125
10-Hydroxydecanoate
-
-
0.08
11-Hydroxyundecanoate
-
-
40
9-Hydroxynonanoate
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-
0.066
NAD+
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-
SPECIFIC ACTIVITY [µmol/min/mg]
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
additional information
-
223, units defined as change in optical density at 340 nm of 0.001/min
pH OPTIMUM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
pH RANGE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
9 - 11
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about half-maximal activity at pH 9.0 and 11.0
TEMPERATURE OPTIMUM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE
-
-
Manually annotated by BRENDA team
-
-
Manually annotated by BRENDA team
LOCALIZATION
ORGANISM
UNIPROT
COMMENTARY hide
GeneOntology No.
LITERATURE
SOURCE
STORAGE STABILITY
ORGANISM
UNIPROT
LITERATURE
4°C, crude extract stable for a week
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Purification/COMMENTARY
ORGANISM
UNIPROT
LITERATURE