Reference on EC 1.1.98.3 - decaprenylphospho-beta-D-ribofuranose 2-dehydrogenase
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Trefzer, C.; Rengifo-Gonzalez, M.; Hinner, M.J.; Schneider, P.; Makarov, V.; Cole, S.T.; Johnsson, K.
Benzothiazinones: prodrugs that covalently modify the decaprenylphosphoryl-beta-D-ribose 2-epimerase DprE1 of Mycobacterium tuberculosis
J. Am. Chem. Soc.
132
13663-13665
2010
Mycobacterium tuberculosis (P9WJF1), Mycobacterium tuberculosis, Mycobacterium tuberculosis H37Rv (P9WJF1)
Trefzer, C.; Skovierova, H.; Buroni, S.; Bobovska, A.; Nenci, S.; Molteni, E.; Pojer, F.; Pasca, M.; Makarov, V.; Cole, S.; Riccardi, G.; Mikusova, K.; Johnsson, K.
Benzothiazinones are suicide inhibitors of mycobacterial decaprenylphosphoryl-beta-D-ribofuranose 2'-oxidase DprE1
J. Am. Chem. Soc.
134
912-915
2012
Mycolicibacterium smegmatis (A0R607)
Mikusova, K.; Huang, H.; Yagi, T.; Holsters, M.; Vereecke, D.; DHaeze, W.; Scherman, M.S.; Brennan, P.J.; McNeil, M.R.; Crick, D.C.
Decaprenylphosphoryl arabinofuranose, the donor of the D-arabinofuranosyl residues of mycobacterial arabinan, is formed via a two-step epimerization of decaprenylphosphoryl ribose
J. Bacteriol.
187
8020-8025
2005
Mycobacterium tuberculosis (P9WJF1), Mycobacterium tuberculosis H37Rv (P9WJF1)
Crellin, P.K.; Brammananth, R.; Coppel, R.L.
Decaprenylphosphoryl-beta-D-ribose 2-epimerase, the target of benzothiazinones and dinitrobenzamides, is an essential enzyme in Mycobacterium smegmatis
PLoS ONE
6
e16869
2011
Mycolicibacterium smegmatis (A0R607), Mycolicibacterium smegmatis
Ribeiro, A.L.; Degiacomi, G.; Ewann, F.; Buroni, S.; Incandela, M.L.; Chiarelli, L.R.; Mori, G.; Kim, J.; Contreras-Dominguez, M.; Park, Y.S.; Han, S.J.; Brodin, P.; Valentini, G.; Rizzi, M.; Riccardi, G.; Pasca, M.R.
Analogous mechanisms of resistance to benzothiazinones and dinitrobenzamides in Mycobacterium smegmatis
PLoS ONE
6
e26675
2011
Mycolicibacterium smegmatis (A0R607), Mycolicibacterium smegmatis
Christophe, T.; Jackson, M.; Hee, K.; Fenistein, D.; Contreras-Dominguez, M.; Kim, J.; Genovesio, A.; Carralot, J.; Ewann, F.; Kim, E.; Lee, S.; Kang, S.; Seo, M.; Eun, J.; Skovierova, H.; Pham, H.; Riccardi, G.; Youn, N.; Marsollier, L.; Kempf, M.; Jol
High content screening identifies decaprenyl-phosphoribose 2'-epimerase as a target for intracellular antimycobacterial inhibitors
PLoS Pathog.
5
e1000645
2009
Mycobacterium tuberculosis (P9WJF1), Mycobacterium tuberculosis H37Rv (P9WJF1)
Batt, S.M.; Jabeen, T.; Bhowruth, V.; Quill, L.; Lund, P.A.; Eggeling, L.; Alderwick, L.J.; Fuetterer, K.; Besra, G.S.
Structural basis of inhibition of Mycobacterium tuberculosis DprE1 by benzothiazinone inhibitors
Proc. Natl. Acad. Sci. USA
109
11354-11359
2012
Mycobacterium tuberculosis (P9WJF1), Mycobacterium tuberculosis, Mycobacterium tuberculosis H37Rv (P9WJF1)
Batt, S.M.; Cacho Izquierdo, M.; Castro Pichel, J.; Stubbs, C.J.; Vela-Glez Del Peral, L.; Perez-Herran, E.; Dhar, N.; Mouzon, B.; Rees, M.; Hutchinson, J.P.; Young, R.J.; McKinney, J.D.; Barros Aguirre, D.; Ballell, L.; Besra, G.S.; Argyrou, A.
Whole cell target engagement identifies novel inhibitors of Mycobacterium tuberculosis decaprenylphosphoryl-beta-D-ribose oxidase
ACS Infect. Dis.
1
615-626
2015
Mycobacterium tuberculosis (P9WJF1), Mycobacterium tuberculosis, Mycobacterium tuberculosis H37Rv (P9WJF1)
Makarov, V.; Neres, J.; Hartkoorn, R.C.; Ryabova, O.B.; Kazakova, E.; Sarkan, M.; Huszar, S.; Piton, J.; Kolly, G.S.; Vocat, A.; Conroy, T.M.; Mikusova, K.; Cole, S.T.
The 8-pyrrole-benzothiazinones are noncovalent inhibitors of DprE1 from Mycobacterium tuberculosis
Antimicrob. Agents Chemother.
59
4446-4452
2015
Mycobacterium tuberculosis (P9WJF1), Mycobacterium tuberculosis, Mycobacterium tuberculosis H37Rv (P9WJF1)
Foo, C.S.; Lechartier, B.; Kolly, G.S.; Boy-Roettger, S.; Neres, J.; Rybniker, J.; Lupien, A.; Sala, C.; Piton, J.; Cole, S.T.
Characterization of DprE1-mediated benzothiazinone resistance in Mycobacterium tuberculosis
Antimicrob. Agents Chemother.
60
6451-6459
2016
Mycobacterium tuberculosis (P9WJF1), Mycobacterium tuberculosis, Mycobacterium tuberculosis H37Rv (P9WJF1)
Riccardi, G.; Pasca, M.R.; Chiarelli, L.R.; Manina, G.; Mattevi, A.; Binda, C.
The DprE1 enzyme, one of the most vulnerable targets of Mycobacterium tuberculosis
Appl. Microbiol. Biotechnol.
97
8841-8848
2013
Mycobacterium tuberculosis
Landge, S.; Mullick, A.B.; Nagalapur, K.; Neres, J.; Subbulakshmi, V.; Murugan, K.; Ghosh, A.; Sadler, C.; Fellows, M.D.; Humnabadkar, V.; Mahadevaswamy, J.; Vachaspati, P.; Sharma, S.; Kaur, P.; Mallya, M.; Rudrapatna, S.; Awasthy, D.; Sambandamurthy, V.K.; Pojer, F.; Cole, S.T.; Balganesh, T.S.; Ug, U.g.a.
Discovery of benzothiazoles as antimycobacterial agents: Synthesis, structure-activity relationships and binding studies with Mycobacterium tuberculosis decaprenylphosphoryl-beta-D-ribose 2'-oxidase
Bioorg. Med. Chem.
23
7694-7710
2015
Mycobacterium tuberculosis (P9WJF1)
Panda, M.; Ramachandran, S.; Ramachandran, V.; Shirude, P.S.; Humnabadkar, V.; Nagalapur, K.; Sharma, S.; Kaur, P.; Guptha, S.; Narayan, A.; Mahadevaswamy, J.; Ambady, A.; Hegde, N.; Rudrapatna, S.S.; Hosagrahara, V.P.; Sambandamurthy, V.K.; Raichurkar, A.
Discovery of pyrazolopyridones as a novel class of noncovalent DprE1 inhibitor with potent anti-mycobacterial activity
J. Med. Chem.
57
4761-4771
2014
Mycobacterium tuberculosis (P9WJF1), Mycobacterium tuberculosis, Mycolicibacterium smegmatis (P9WJF1), Mycobacterium tuberculosis H37Rv (P9WJF1)
Naik, M.; Humnabadkar, V.; Tantry, S.J.; Panda, M.; Narayan, A.; Guptha, S.; Panduga, V.; Manjrekar, P.; Jena, L.K.; Koushik, K.; Shanbhag, G.; Jatheendranath, S.; Manjunatha, M.R.; Gorai, G.; Bathula, C.; Rudrapatna, S.; Achar, V.; Sharma, S.; Ambady, A.; Hegde, N.; Mahadevaswamy, J.; Kaur, P.; Samb, S.a.m.b.a.
4-aminoquinolone piperidine amides: noncovalent inhibitors of DprE1 with long residence time and potent antimycobacterial activity
J. Med. Chem.
57
5419-5434
2014
Mycobacterium tuberculosis (P9WJF1), Mycobacterium tuberculosis
Bhutani, I.; Loharch, S.; Gupta, P.; Madathil, R.; Parkesh, R.
Structure, dynamics, and interaction of Mycobacterium tuberculosis (Mtb) DprE1 and DprE2 examined by molecular modeling, simulation, and electrostatic studies
PLoS ONE
10
e0119771
2015
Mycobacterium tuberculosis (P9WJF0), Mycobacterium tuberculosis (P9WJF1), Mycobacterium tuberculosis, Mycobacterium tuberculosis H37Rv (P9WJF1), Mycobacterium tuberculosis CDC 1551 (P9WJF0)
Li, H.; Jogl, G.
Crystal structure of decaprenylphosphoryl-beta-D-ribose 2'-epimerase from Mycobacterium smegmatis
Proteins
81
538-543
2013
Mycolicibacterium smegmatis (A0R607), Mycolicibacterium smegmatis, Mycolicibacterium smegmatis ATCC 700084 (A0R607)
Rogacki, M.K.; Pitta, E.; Balabon, O.; Huss, S.; Lopez-Roman, E.M.; Argyrou, A.; Blanco-Ruano, D.; Cacho, M.; Vande Velde, C.M.L.; Augustyns, K.; Ballell, L.; Barros, D.; Bates, R.H.; Cunningham, F.; Van der Veken, P.
Identification and profiling of hydantoins-A novel class of potent antimycobacterial DprE1 inhibitors
J. Med. Chem.
61
11221-11249
2018
Mycobacterium tuberculosis (P9WJF1), Mycobacterium tuberculosis, Mycobacterium tuberculosis H37Rv (P9WJF1)
Karabanovich, G.; Dusek, J.; Savkova, K.; Pavlis, O.; Pavkova, I.; Korabecny, J.; Kucera, T.; Kocova Vlckova, H.; Huszar, S.; Konyarikova, Z.; Konecna, K.; JandOurek, O.; Stolarkova, J.; Kordulakova, J.; Vavrova, K.; Pavek, P.
Development of 3,5-dinitrophenyl-containing 1,2,4-triazoles and their trifluoromethyl analogues as highly efficient antitubercular agents inhibiting decaprenylphosphoryl-beta-D-ribofuranose 2'-oxidase
J. Med. Chem.
62
8115-8139
2019
Mycobacterium tuberculosis (P9WJF1), Mycobacterium tuberculosis H37Rv (P9WJF1)
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