Information on EC 1.11.1.2 - NADPH peroxidase

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The expected taxonomic range for this enzyme is: Bacteria, Eukaryota

EC NUMBER
COMMENTARY hide
1.11.1.2
-
RECOMMENDED NAME
GeneOntology No.
NADPH peroxidase
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
NADPH + H+ + H2O2 = NADP+ + 2 H2O
show the reaction diagram
-
-
-
-
REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
oxidation
redox reaction
reduction
SYSTEMATIC NAME
IUBMB Comments
NADPH:hydrogen-peroxide oxidoreductase
-
CAS REGISTRY NUMBER
COMMENTARY hide
9029-51-0
-
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
B-1388 strain
-
-
Manually annotated by BRENDA team
B-1388 strain
-
-
Manually annotated by BRENDA team
-
-
-
Manually annotated by BRENDA team
strains ZAS-1 and ZAS-2
-
-
Manually annotated by BRENDA team
-
-
-
Manually annotated by BRENDA team
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
NADH + H2O2
NAD+ + H2O
show the reaction diagram
-
25% of the rate with NADPH
-
?
NADPH + H+ + H2O2
NADP+ + 2 H2O
show the reaction diagram
NADPH + H2O2
NADP+ + H2O
show the reaction diagram
METALS and IONS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
Mn2+
-
inhibitory
INHIBITORS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
ascorbic acid
-
-
cysteine
-
-
hydroxylamine
-
-
methylene blue
-
-
ACTIVATING COMPOUND
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
O2
-
aerobic conditions required for reaction
SPECIFIC ACTIVITY [µmol/min/mg]
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
0.003
-
strain ZAS-1
0.005
-
strain ZAS-2
35.3
-
cells in exponential phase growth
39.6
-
cells in stationary phase growth
SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE
LOCALIZATION
ORGANISM
UNIPROT
COMMENTARY hide
GeneOntology No.
LITERATURE
SOURCE
TEMPERATURE STABILITY
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
100
-
no activity after 1 min
STORAGE STABILITY
ORGANISM
UNIPROT
LITERATURE
-15°C, pH 7, months, no loss of activity
-
Purification/COMMENTARY
ORGANISM
UNIPROT
LITERATURE
partial, separation of subcellular fractions
-