Information on EC 1.12.98.3 - Methanosarcina-phenazine hydrogenase

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The expected taxonomic range for this enzyme is: Archaea, Bacteria

EC NUMBER
COMMENTARY hide
1.12.98.3
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RECOMMENDED NAME
GeneOntology No.
Methanosarcina-phenazine hydrogenase
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
H2 + 2-(2,3-dihydropentaprenyloxy)phenazine = 2-dihydropentaprenyloxyphenazine
show the reaction diagram
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REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
oxidation
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redox reaction
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reduction
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PATHWAY
BRENDA Link
KEGG Link
MetaCyc Link
coenzyme B/coenzyme M regeneration
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coenzyme M biosynthesis
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SYSTEMATIC NAME
IUBMB Comments
hydrogen:2-(2,3-dihydropentaprenyloxy)phenazine oxidoreductase
Contains nickel, iron-sulfur clusters and cytochrome b. The enzyme from some sources contains selenocysteine.
CAS REGISTRY NUMBER
COMMENTARY hide
9027-05-8
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ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
Q8PU58: subunit A, F1SVL1: subunit C, Q8PZ67: subunit F, F1SVH7: subunit B, F1SVE4: subunit D, Q8PU59: subunit H, Q8PU60: subunit I, Q8PU61: subunit J, F1SVE0: subunit K, F1SVK0; subunit L, F1SVH9: subunit M, F1SVL2: subunit N, F1SVE1: subunit O
Q8PU58 and F1SVL1 and Q8PZ67 and F1SVH7 and F1SVE4 and Q8PU59 and Q8PU60 and Q8PU61 and F1SVE0 and F1SVK0 and F1SVH9 and F1SVL2 and F1SVE1
SwissProt
Manually annotated by BRENDA team
GENERAL INFORMATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
physiological function
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
H2 + 2-(2,3-dihydropentaprenyloxy)phenazine
2-dihydropentaprenyloxyphenazine
show the reaction diagram
H2 + 2-hydroxyphenazine
dihydro-2-hydroxyphenazine
show the reaction diagram
H2 + oxidized methyl viologen
reduced methyl viologen
show the reaction diagram
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?
additional information
?
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NATURAL SUBSTRATES
NATURAL PRODUCTS
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
H2 + 2-(2,3-dihydropentaprenyloxy)phenazine
2-dihydropentaprenyloxyphenazine
show the reaction diagram
COFACTOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
coenzyme F420
Q8PU58 and F1SVL1 and Q8PZ67 and F1SVH7 and F1SVE4 and Q8PU59 and Q8PU60 and Q8PU61 and F1SVE0 and F1SVK0 and F1SVH9 and F1SVL2 and F1SVE1
the reaction is dependent on the cofactor F420
METALS and IONS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
Co2+
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hydrogenase D
LOCALIZATION
ORGANISM
UNIPROT
COMMENTARY hide
GeneOntology No.
LITERATURE
SOURCE
SUBUNITS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
Purification/COMMENTARY
ORGANISM
UNIPROT
LITERATURE
Cloned/COMMENTARY
ORGANISM
UNIPROT
LITERATURE
expression in Escherichia coli
Q8PU58 and F1SVL1 and Q8PZ67 and F1SVH7 and F1SVE4 and Q8PU59 and Q8PU60 and Q8PU61 and F1SVE0 and F1SVK0 and F1SVH9 and F1SVL2 and F1SVE1
plasmid manipulation and isolation in Escherichia coli, promoter fusion plasmids are transformed into Methanosarcina acetivorans WWM82 via liposome-mediated transformation
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plasmid manipulation and isolation in Escherichia coli, promoter fusion plasmids are transformed into Methanosarcina barkeri WWM85 via liposome-mediated transformation
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