Reference on EC 1.13.11.33 - arachidonate 15-lipoxygenase
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REF. 
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Lin, B.B.; Lin, Y.S.
Selective inhibition activity on 15-lipoxygenase of squalene isolated from Prunus persica (L.) Batsch
Chem. Express
7
297-300
1992
Prunus persica
-
Ford-Hutchinson, A.W.
Arachidonate 15-lipoxygenase; characteristics and potential biological significance
Eicosanoids
4
65-74
1991
Oryctolagus cuniculus, Homo sapiens
Kuehn, H.; Hayess, K.; Holzhuetter, H.G.; Zablotzki, D.A.; Myagkova, G.I.; Schewe, T.
Inactivation of 15-lipoxygenases by acetylenic fatty acids
Biomed. Biochim. Acta
50
835-839
1991
Oryctolagus cuniculus, Glycine max
Luther, H.; Jordanov, D.; Ludwig, P.; Schewe, T.
Inhibition of rabbit erythroid 15-lipoxygenase and sheep vesicular gland prostaglandin H synthase by gallic esters
Pharmazie
46
134-136
1991
Oryctolagus cuniculus
Izumi, T.; Radmark, O.; Joernvall, H.; Samuelsson, B.
Purification of two forms of arachidonate 15-lipoxygenase from human leukocytes
Eur. J. Biochem.
202
1231-1238
1991
Homo sapiens
Nichols, R.C.; Vanderhoek, J.Y.
Calcium regulation of the human PMN cytosolic 15-lipoxygenase
Biochim. Biophys. Acta
1085
77-81
1991
Homo sapiens
German, J.B.; Creveling, R.K.
Identification and characterization of a 15-lipoxygenase from fish gills
J. Agric. Food Chem.
38
2144-2147
1990
Oncorhynchus mykiss
Izumi, T.; Radmark, O.; Samuelsson, B.
Purification of 15-lipoxygenase from human keukocytes, evidence for the presebce of isozymes
Adv. Prostaglandin Thromboxane Leukot. Res.
21
101-104
1990
Homo sapiens
-
Sloane, D.L.; Browner, M.F.; Dauter, Z.; Wilson, K.; Fletterick, R.J.; Sigal, E.
Purification and crystallization of 15-lipoxygenase from rabbit reticulocytes
Biochem. Biophys. Res. Commun.
173
507-513
1990
Oryctolagus cuniculus
Sigal, E.; Grunberger, D.; Highland, E.; Gross, C.; Dixon, R.A.F.; Craik, C.S.
Expression of cloned human reticulocyte 15-lipoxygenase and immunological evidence that 15-lipoxygenases of different cell types are related
J. Biol. Chem.
265
5113-5120
1990
Homo sapiens
Sigal, E.; Grunberger, D.; Cashman, J.R.; Craik, C.S.; Caughey, G.H.; Nadel, J.A.
Arachidonate 15-lipoxygenase from human eosinophil-enriched leukocytes: partial purification and properties
Biochem. Biophys. Res. Commun.
150
376-383
1988
Homo sapiens
Sigal, E.; Craik, C.S.; Dixon, R.A.F.; Nadel, J.A.
Cloning and expression of human arachidonate 15-lipoxygenase
Trans. Assoc. Am. Physicians
102
176-184
1989
Homo sapiens
Sigal, E.; Grunberger, D.; Craik, C.S.; Caughey, G.H.; Nadel, J.A.
Arachidonate 15-lipoxygenase (omega-6 lipoxygenase) from human leukocytes. Purification and structural homology to other mammalian lipoxygenases
J. Biol. Chem.
263
5328-5332
1988
Homo sapiens
Burrall, B.A.; Cheung, M.; Chiu, A.; Goetzel, E.J.
Enzymatic properties of the 15-lipoxygenase of human cultured keratinocytes
J. Invest. Dermatol.
91
294-297
1988
Homo sapiens
Soberman, R.J.; Harper, T.W.; Betteridge, D.; Lewis, R.A.; Austen, K.F.
Characterization and separation of the arachidonic acid 5-lipoxygenase and linoleic acid omega-6 lipoxygenase (arachidonic acid 15-lipoxygenase) of human polymorphonuclear leukocytes
J. Biol. Chem.
260
4508-4515
1985
Homo sapiens
Rapoport, S.M.; Schewe, T.; Wiesner, R.; Halangk, W.; Ludwig, P.; Janicke-Hoehne, M.; Tannert, C.; Hiebsch, C.; Klatt, D.
The lipoxygenase of reticulocytes. Purification, characterization and biological dynamics of the lipoxygenase; its identity with the respiratory inhibitors of the reticulocyte
Eur. J. Biochem.
96
545-561
1979
Oryctolagus cuniculus
Jung, G.; Yang, D.C.; Nakao, A.
Oxygenation of phosphatidylcholine by human polymorphonuclear leukocyte 15-lipoxygenase
Biochem. Biophys. Res. Commun.
130
559-566
1985
Homo sapiens
Narumiya, S.; Salmon, J.A.
Arachidonic acid-15-lipoxygenase from rabbit peritoneal polymorphonuclear leukocytes
Methods Enzymol.
86
45-48
1982
Oryctolagus cuniculus
Doerge, D.R.; Corbett, M.D.
An arachidonic acid-specific lipoxygenase from the gorgonian coral Pseudoplexaura porosa
Experientia
38
901-902
1982
Pseudoplexaura porosa
-
Bryant, R.W.; Bailey, J.M.; Schewe, T.; Rapoport, S.M.
Positional specificity of a reticulocyte lipoxygenase. Conversion of arachidonic acid to 15-S-hydroperoxy-eicosatetraenoic acid
J. Biol. Chem.
257
6050-6055
1982
Oryctolagus cuniculus
Sloane, D.L.; leung, R.; Craik, C.S.; Sigal, E.
A primary determinant for lipoxygenase positional specificity
Nature
354
149-1152
1991
Homo sapiens
Borngraber, S.; Grabenhorst, E.; Anton, M.; Conradt, H.; Kuhn, H.
Intra- and extracellular expression of rabbit reticulocyte 15-lipoxygenase in the baculovirus/insect cell system
Protein Expr. Purif.
14
237-246
1998
Oryctolagus cuniculus
Kuehn, H.; Heydeck, D.; Brinckman, R.; Trebus, F.
Regulation of cellular 15-lipoxygenase activity on pretranslational, translational, and posttranslational levels
Lipids
34
S273-S279
1999
Oryctolagus cuniculus, Homo sapiens, Mus musculus, Rattus norvegicus
-
Walther, M.; Holzhutter, H.G.; Kuban, R.J.; Wiesner, R.; Rathmann, J.; Kuhn, H.
The inhibition of mammalian 15-lipoxygenases by the anti-inflammatory drug ebselen: dual-type mechanism involving covalent linkage and alteration of the iron ligand sphere
Mol. Pharmacol.
56
196-203
1999
Oryctolagus cuniculus
Reddy, N.; Everhart, A.; Eling, T.; Glasgow, W.
Characterization of a 15-lipoxygenase in human breast carcinoma BT-20 cells: stimulation of 13-HODE formation by TGFa/EGF
Biochem. Biophys. Res. Commun.
231
111-116
1997
Homo sapiens
Kuehn, H.; Barnett, J.; Grunberger, D.; Baecker, P.; Chow, J.; Nguyen, B.; Bursztyn-Pettegrew, H.; Chan, H.; Sigal, E.
Overexpression, purification and characterization of human recombinant 15-lipoxygenase
Biochim. Biophys. Acta
1169
80-89
1993
Homo sapiens
Liminga, M.; Hornsten, L.; Sprecher, H.W.; Oliw, E.H.
Arachidonate 15-lipoxygenase in human corneal epithelium and 12- and 15-lipoxygenases in bovine corneal epithelium: comparison with other bovine 12-lipoxygenases
Biochim. Biophys. Acta
1210
288-296
1994
Bos taurus, Homo sapiens
Tang, S.; Bhatia, B.; Maldonado, C.J.; Yang, P.; Newman, R.A.; Liu, J.; Chandra, D.; Traag, J.; Klein, R.D.; Fischer, S.M.; Chopra, D.; Shen, J.; Zhau, H.E.; Chung, L.W.K.; Tang, D.G.
Evidence that arachidonate 15-lipoxygenase 2 is a negative cell cycle regulator in normal prostate epithelial cells
J. Biol. Chem.
277
16189-16201
2002
Homo sapiens (O15296), Homo sapiens
Kilty, I.; Logan, A.; Vickers, P.J.
Differential characteristics of human 15-lipoxygenase isozymes and a novel splice variant of 15S-lipoxygenase
Eur. J. Biochem.
266
83-93
1999
Homo sapiens
Mogul, R.; Johansen, E.; Holman, T.R.
Oleyl sulfate reveals allosteric inhibition of soybean lipoxygenase-1 and human 15-lipoxygenase
Biochemistry
39
4801-4807
2000
Homo sapiens
Schewe, T.
15-Lipoxygenase-1: A prooxidant enzyme
Biol. Chem.
383
365-374
2002
Oryctolagus cuniculus, Homo sapiens
MacMillan, D.K.; Hill, E.; Sala, A.; Sigal, E.; Shuman, T.; Henson, P.M.; Murphy, R.C.
Eosinophil 15-lipoxygenase is a leukotriene A4 synthase
J. Biol. Chem.
269
26663-26668
1994
Homo sapiens
Sadik, C.D.; Sies, H.; Schewe, T.
Inhibition of 15-lipoxygenases by flavonoids: structure-activity relations and mode of action
Biochem. Pharmacol.
65
773-781
2003
Glycine max, Oryctolagus cuniculus
Segraves, E.N.; Holman, T.R.
Kinetic investigations of the rate-limiting step in human 12- and 15-lipoxygenase
Biochemistry
42
5236-5243
2003
Homo sapiens
Vijayvergiya, C.; De Angelis, D.; Walther, M.; Kuhn, H.; Duvoisin, R.M.; Smith, D.H.; Wiedmann, M.
High-level expression of rabbit 15-lipoxygenase induces collapse of the mitochondrial pH gradient in cell culture
Biochemistry
43
15296-15302
2004
Oryctolagus cuniculus
Ivanov, I.; Romanov, S.; Ozdoba, C.; Holzhutter, H.G.; Myagkova, G.; Kuhn, H.
Enantioselective substrate specificity of 15-lipoxygenase 1
Biochemistry
43
15720-15728
2004
Oryctolagus cuniculus (P12530)
Gundersen, L.L.; Malterud, K.E.; Negussie, A.H.; Rise, F.; Teklu, S.; Ostby, O.B.
Indolizines as novel potent inhibitors of 15-lipoxygenase
Bioorg. Med. Chem.
11
5409-5415
2003
Oryctolagus cuniculus, Glycine max
Teklu, S.; Gundersen, L.L.; Larsen, T.; Malterud, K.E.; Rise, F.
Indolizine 1-sulfonates as potent inhibitors of 15-lipoxygenase from soybeans
Bioorg. Med. Chem.
13
3127-3139
2005
Glycine max
Zhu, D.; Medhora, M.; Campbell, W.B.; Spitzbarth, N.; Baker, J.E.; Jacobs, E.R.
Chronic hypoxia activates lung 15-lipoxygenase, which catalyzes production of 15-HETE and enhances constriction in neonatal rabbit pulmonary arteries
Circ. Res.
92
992-1000
2003
Oryctolagus cuniculus
Chang, M.S.; Schneider, C.; Roberts, R.L.; Shappell, S.B.; Haselton, F.R.; Boeglin, W.E.; Brash, A.R.
Detection and subcellular localization of two 15S-lipoxygenases in human cornea
Invest. Ophthalmol. Vis. Sci.
46
849-856
2005
Homo sapiens
Bhatia, B.; Maldonado, C.J.; Tang, S.; Chandra, D.; Klein, R.D.; Chopra, D.; Shappell, S.B.; Yang, P.; Newman, R.A.; Tang, D.G.
Subcellular localization and tumor-suppressive functions of 15-lipoxygenase 2 (15-LOX2) and its splice variants
J. Biol. Chem.
278
25091-25100
2003
Homo sapiens
Walther, M.; Wiesner, R.; Kuhn, H.
Investigations into calcium-dependent membrane association of 15-lipoxygenase-1. Mechanistic roles of surface-exposed hydrophobic amino acids and calcium
J. Biol. Chem.
279
3717-3725
2004
Oryctolagus cuniculus
Segraves, E.N.; Shah, R.R.; Segraves, N.L.; Johnson, T.A.; Whitman, S.; Sui, J.K.; Kenyon, V.A.; Cichewicz, R.H.; Crews, P.; Holman, T.R.
Probing the activity differences of simple and complex brominated aryl compounds against 15-soybean, 15-human, and 12-human lipoxygenase
J. Med. Chem.
47
4060-4065
2004
Glycine max, Homo sapiens
Coffa, G.; Brash, A.R.
A single active site residue directs oxygenation stereospecificity in lipoxygenases: Stereocontrol is linked to the position of oxygenation
Proc. Natl. Acad. Sci. USA
101
15579-15584
2004
Homo sapiens
Vance, R.E.; Hong, S.; Gronert, K.; Serhan, C.N.; Mekalanos, J.J.
The opportunistic pathogen Pseudomonas aeruginosa carries a secretable arachidonate 15-lipoxygenase
Proc. Natl. Acad. Sci. USA
101
2135-2139
2004
Pseudomonas aeruginosa
Aggarwal, N.T.; Holmes, B.B.; Cui, L.; Viita, H.; Yla-Herttuala, S.; Campbell, W.B.
Adenoviral expression of 15-lipoxygenase-1 in rabbit aortic endothelium: role in arachidonic acid-induced relaxation
Am. J. Physiol. Heart Circ. Physiol.
292
H1033-H1041
2007
Homo sapiens
Reinhold, S.W.; Vitzthum, H.; Filbeck, T.; Wolf, K.; Lattas, C.; Riegger, G.A.; Kurtz, A.; Kraemer, B.K.
Gene expression of 5-, 12-, and 15-lipoxygenases and leukotriene receptors along the rat nephron
Am. J. Physiol. Renal Physiol.
290
F864-F872
2006
Rattus norvegicus (Q8K4F2)
Utenova, B.T.; Malterud, K.E.; Rise, F.
Antioxidant activity of O-protected derivatives of (-)-epigallocatechin-3-gallate: inhibition of soybean and rabbit 15-lipoxygenases
ARKIVOC
2007
6-16
2007
Oryctolagus cuniculus
-
Tang, X.; Holmes, B.B.; Nithipatikom, K.; Hillard, C.J.; Kuhn, H.; Campbell, W.B.
Reticulocyte 15-lipoxygenase-I is important in acetylcholine-induced endothelium-dependent vasorelaxation in rabbit aorta
Arterioscler. Thromb. Vasc. Biol.
26
78-84
2006
Oryctolagus cuniculus
Andersson, E.; Schain, F.; Svedling, M.; Claesson, H.; Forsell, P.K.
Interaction of human 15-lipoxygenase-1 with phosphatidylinositol bisphosphates results in increased enzyme activity
Biochim. Biophys. Acta
1761
1498-1505
2006
Homo sapiens
Deschamps, J.D.; Kenyon, V.A.; Holman, T.R.
Baicalein is a potent in vitro inhibitor against both reticulocyte 15-human and platelet 12-human lipoxygenases
Bioorg. Med. Chem.
14
4295-4301
2006
Homo sapiens
Weinstein, D.S.; Liu, W.; Gu, Z.; Langevine, C.; Ngu, K.; Fadnis, L.; Combs, D.W.; Sitkoff, D.; Ahmad, S.; Zhuang, S.; Chen, X.; Wang, F.L.; Loughney, D.A.; Atwal, K.S.; Zahler, R.; Macor, J.E.; Madsen, C.S.; Murugesan, N.
Tryptamine and homotryptamine-based sulfonamides as potent and selective inhibitors of 15-lipoxygenase
Bioorg. Med. Chem. Lett.
15
1435-1440
2005
Oryctolagus cuniculus
Shureiqi, I.; Wu, Y.; Chen, D.; Yang, X.L.; Guan, B.; Morris, J.S.; Yang, P.; Newman, R.A.; Broaddus, R.; Hamilton, S.R.; Lynch, P.; Levin, B.; Fischer, S.M.; Lippman, S.M.
The critical role of 15-lipoxygenase-1 in colorectal epithelial cell terminal differentiation and tumorigenesis
Cancer Res.
65
11486-11492
2005
Homo sapiens
Deguchi, A.; Xing, S.W.; Shureiqi, I.; Yang, P.; Newman, R.A.; Lippman, S.M.; Feinmark, S.J.; Oehlen, B.; Weinstein, I.B.
Activation of protein kinase G up-regulates expression of 15-lipoxygenase-1 in human colon cancer cells
Cancer Res.
65
8442-8447
2005
Homo sapiens
Flores, A.M.; Li, L.; McHugh, N.G.; Aneskievich, B.J.
Enzyme association with PPARgamma: evidence of a new role for 15-lipoxygenase type 2
Chem. Biol. Interact.
151
121-132
2005
Homo sapiens
Wangensteen, H.; Miron, A.; Alamgir, M.; Rajia, S.; Samuelsen, A.B.; Malterud, K.E.
Antioxidant and 15-lipoxygenase inhibitory activity of rotenoids, isoflavones and phenolic glycosides from Sarcolobus globosus
Fitoterapia
77
290-295
2006
Sarcolobus globosus
Cho, H.; Gallaher, D.D.; Csallany, A.S.
Conjugated linoleic acid, cis-9,trans-11, is a substrate for pulmonary 15-lipoxygenase-1 in rat
J. Agric. Food Chem.
53
7262-7266
2005
Rattus norvegicus
Kelavkar, U.; Lin, Y.; Landsittel, D.; Chandran, U.; Dhir, R.
The yin and yang of 15-lipoxygenase-1 and delta-desaturases: Dietary omega-6 linoleic acid metabolic pathway in prostate
J. Carcinog.
5
9-9
2006
Homo sapiens
Bhattacharjee, A.; Xu, B.; Frank, D.A.; Feldman, G.M.; Cathcart, M.K.
Monocyte 15-lipoxygenase expression is regulated by a novel cytosolic signaling complex with protein kinase C delta and tyrosine-phosphorylated Stat3
J. Immunol.
177
3771-3781
2006
Homo sapiens
Kim, J.S.; Baek, S.J.; Bottone, F.G.; Sali, T.; Eling, T.E.
Overexpression of 15-lipoxygenase-1 induces growth arrest through phosphorylation of p53 in human colorectal cancer cells
Mol. Cancer Res.
3
511-517
2005
Homo sapiens
Kong, J.; Sumaroka, M.; Eastmond, D.L.; Liebhaber, S.A.
Shared stabilization functions of pyrimidine-rich determinants in the erythroid 15-lipoxygenase and alpha-globin mRNAs
Mol. Cell. Biol.
26
5603-5614
2006
Homo sapiens
Kelavkar, U.P.; Parwani, A.V.; Shappell, S.B.; Martin, W.D.
Conditional expression of human 15-lipoxygenase-1 in mouse prostate induces prostatic intraepithelial neoplasia: the FLiMP mouse model
Neoplasia
8
510-522
2006
Homo sapiens
Subbarayan, V.; Krieg, P.; Hsi, L.C.; Kim, J.; Yang, P.; Sabichi, A.L.; Llansa, N.; Mendoza, G.; Logothetis, C.J.; Newman, R.A.; Lippman, S.M.; Menter, D.G.
15-Lipoxygenase-2 gene regulation by its product 15-(S)-hydroxyeicosatetraenoic acid through a negative feedback mechanism that involves peroxisome proliferator-activated receptor gamma
Oncogene
25
6015-6025
2006
Homo sapiens
Kim, K.S.; Chun, H.S.; Yoon, J.H.; Lee, J.G.; Lee, J.H.; Yoo, J.B.
Expression of 15-lipoxygenase-1 in human nasal epithelium: its implication in mucociliary differentiation
Prostaglandins Leukot. Essent. Fatty Acids
73
77-83
2005
Homo sapiens, Mus musculus
Jiang, W.G.; Watkins, G.; Douglas-Jones, A.; Mansel, R.E.
Reduction of isoforms of 15-lipoxygenase (15-LOX)-1 and 15-LOX-2 in human breast cancer
Prostaglandins Leukot. Essent. Fatty Acids
74
235-245
2006
Homo sapiens
Sen, M.; McHugh, K.; Hutzley, J.; Philips, B.J.; Dhir, R.; Parwani, A.V.; Kelavkar, U.P.
Orthotopic expression of human 15-lipoxygenase (LO)-1 in the dorsolateral prostate of normal wild-type C57BL/6 mouse causes PIN-like lesions
Prostaglandins Other Lipid Mediat.
81
1-13
2006
Homo sapiens
Fischer, K.A.; Van Leyen, K.; Lovercamp, K.W.; Manandhar, G.; Sutovsky, M.; Feng, D.; Safranski, T.; Sutovsky, P.
15-Lipoxygenase is a component of the mammalian sperm cytoplasmic droplet
Reproduction
130
213-222
2005
Equus caballus, Homo sapiens, Mus musculus, Sus scrofa, Babyrousa babyrussa
Wang, D.; Chen, S.; Feng, Y.; Yang, Q.; Campbell, B.H.; Tang, X.; Campbell, W.B.
Reduced expression of 15-lipoxygenase 2 in human head and neck carcinomas
Tumour Biol.
27
261-273
2006
Homo sapiens
Chawengsub, Y.; Aggarwal, N.T.; Nithipatikom, K.; Gauthier, K.M.; Anjaiah, S.; Hammock, B.D.; Falck, J.R.; Campbell, W.B.
Identification of 15-hydroxy-11,12-epoxyeicosatrienoic acid as a vasoactive 15-lipoxygenase metabolite in rabbit aorta
Am. J. Physiol. Heart Circ. Physiol.
294
H1348-H1356
2008
Oryctolagus cuniculus
Wen, Y.; Gu, J.; Vandenhoff, G.E.; Liu, X.; Nadler, J.L.
Role of 12/15-lipoxygenase in the expression of MCP-1 in mouse macrophages
Am. J. Physiol. Heart Circ. Physiol.
294
H1933-H1938
2008
Mus musculus, Mus musculus C57BL/6
Assimes, T.L.; Knowles, J.W.; Priest, J.R.; Basu, A.; Borchert, A.; Volcik, K.A.; Grove, M.L.; Tabor, H.K.; Southwick, A.; Tabibiazar, R.; Sidney, S.; Boerwinkle, E.; Go, A.S.; Iribarren, C.; Hlatky, M.A.; Fortmann, S.P.; Myers, R.M.; Kuhn, H.; Risch, N.; Quertermous, T.
A near null variant of 12/15-LOX encoded by a novel SNP in ALOX15 and the risk of coronary artery disease
Atherosclerosis
198
136-144
2008
Homo sapiens (P16050)
Jacquot, C.; Wecksler, A.T.; McGinley, C.M.; Segraves, E.N.; Holman, T.R.; van der Donk, W.A.
Isotope sensitive branching and kinetic isotope effects in the reaction of deuterated arachidonic acids with human 12- and 15-lipoxygenases
Biochemistry
47
7295-7303
2008
Homo sapiens
Wecksler, A.T.; Kenyon, V.; Deschamps, J.D.; Holman, T.R.
Substrate specificity changes for human reticulocyte and epithelial 15-lipoxygenases reveal allosteric product regulation
Biochemistry
47
7364-7375
2008
Homo sapiens
Huang, L.S.; Kim, M.R.; Jeong, T.S.; Sok, D.E.
Linoleoyl lysophosphatidic acid and linoleoyl lysophosphatidylcholine are efficient substrates for mammalian lipoxygenases
Biochim. Biophys. Acta
1770
1062-1070
2007
Oryctolagus cuniculus
Gulliksson, M.; Brunnstroem, A.; Johannesson, M.; Backman, L.; Nilsson, G.; Harvima, I.; Dahlen, B.; Kumlin, M.; Claesson, H.
Expression of 15-lipoxygenase type-1 in human mast cells
Biochim. Biophys. Acta
1771
1156-1165
2007
Homo sapiens
Bakavoli, M.; Nikpour, M.; Rahimizadeh, M.; Saberi, M.R.; Sadeghian, H.
Design and synthesis of pyrimido[4,5-b][1,4]benzothiazine derivatives, as potent 15-lipoxygenase inhibitors
Bioorg. Med. Chem.
15
2120-2126
2007
Glycine max
Deschamps, J.D.; Gautschi, J.T.; Whitman, S.; Johnson, T.A.; Gassner, N.C.; Crews, P.; Holman, T.R.
Discovery of platelet-type 12-human lipoxygenase selective inhibitors by high-throughput screening of structurally diverse libraries
Bioorg. Med. Chem.
15
6900-6908
2007
Homo sapiens
Vasquez-Martinez, Y.; Ohri, R.V.; Kenyon, V.; Holman, T.R.; Sepulveda-Boza, S.
Structure-activity relationship studies of flavonoids as potent inhibitors of human platelet 12-hLO, reticulocyte 15-hLO-1, and prostate epithelial 15-hLO-2
Bioorg. Med. Chem.
15
7408-7425
2007
Homo sapiens
Russell, W.R.; Scobbie, L.; Duthie, G.G.; Chesson, A.
Inhibition of 15-lipoxygenase-catalysed oxygenation of arachidonic acid by substituted benzoic acids
Bioorg. Med. Chem.
16
4589-4593
2008
Glycine max
Sadeghian, H.; Seyedi, S.M.; Saberi, M.R.; Arghiani, Z.; Riazi, M.
Design and synthesis of eugenol derivatives, as potent 15-lipoxygenase inhibitors
Bioorg. Med. Chem.
16
890-901
2008
Glycine max, Homo sapiens
Weinstein, D.S.; Liu, W.; Ngu, K.; Langevine, C.; Combs, D.W.; Zhuang, S.; Chen, C.; Madsen, C.S.; Harper, T.W.; Robl, J.A.
Discovery of selective imidazole-based inhibitors of mammalian 15-lipoxygenase: highly potent against human enzyme within a cellular environment
Bioorg. Med. Chem. Lett.
17
5115-5120
2007
Homo sapiens
Jedrzejczak-Czechowicz, M.; Lewandowska-Polak, A.; Bienkiewicz, B.; Kowalski, M.L.
Involvement of 15-lipoxygenase and prostaglandin EP receptors in aspirin-triggered 15-hydroxyeicosatetraenoic acid generation in aspirin-sensitive asthmatics
Clin. Exp. Allergy
38
1108-1116
2008
Homo sapiens
Aggarwal, N.T.; Chawengsub, Y.; Gauthier, K.M.; Viita, H.; Yla-Herttuala, S.; Campbell, W.B.
Endothelial 15-lipoxygenase-1 overexpression increases acetylcholine-induced hypotension and vasorelaxation in rabbits
Hypertension
51
246-251
2008
Homo sapiens
Stachowska, E.; Dziedziejko, V.; Safranow, K.; Jakubowska, K.; Olszewska, M.; Machalinski, B.; Chlubek, D.
Effect of conjugated linoleic acids on the activity and mRNA expression of 5- and 15-lipoxygenases in human macrophages
J. Agric. Food Chem.
55
5335-5342
2007
Homo sapiens
Pirillo, A.; Uboldi, P.; Bolego, C.; Kuhn, H.; Catapano, A.L.
The 15-lipoxygenase-modified high density lipoproteins 3 fail to inhibit the TNF-alpha-induced inflammatory response in human endothelial cells
J. Immunol.
181
2821-2830
2008
Homo sapiens
Bakavoli, M.; Sadeghian, H.; Tabatabaei, Z.; Rezaei, E.; Rahimizadeh, M.; Nikpour, M.
SAR comparative studies on pyrimido[4,5-b][1,4] benzothiazine derivatives as 15-lipoxygenase inhibitors, using ab initio calculations
J. Mol. Model.
14
471-478
2008
Glycine max
Succol, F.; Pratico, D.
A role for 12/15 lipoxygenase in the amyloid beta precursor protein metabolism
J. Neurochem.
103
380-387
2007
Homo sapiens
Vincent, C.; Fiancette, R.; Donnard, M.; Bordessoule, D.; Turlure, P.; Trimoreau, F.; Denizot, Y.
5-LOX, 12-LOX and 15-LOX in immature forms of human leukemic blasts
Leuk. Res.
32
1756-1762
2008
Homo sapiens
Schurink, M.; van Berkel, W.J.; Wichers, H.J.; Boeriu, C.G.
Improvement of lipoxygenase inhibition by octapeptides
Peptides
28
2268-2275
2007
Oryctolagus cuniculus
Saam, J.; Ivanov, I.; Walther, M.; Holzhuetter, H.G.; Kuhn, H.
Molecular dioxygen enters the active site of 12/15-lipoxygenase via dynamic oxygen access channels
Proc. Natl. Acad. Sci. USA
104
13319-13324
2007
Oryctolagus cuniculus
Feltenmark, S.; Gautam, N.; Brunnstroem, A.; Griffiths, W.; Backman, L.; Edenius, C.; Lindbom, L.; Bjoerkholm, M.; Claesson, H.E.
Eoxins are proinflammatory arachidonic acid metabolites produced via the 15-lipoxygenase-1 pathway in human Feltenmark, S.; Gautam, N.; Brunnstroem, A.; Griffiths, W.; Backman, L.; Edenius, C.; Lindbom, L.; Bjoerkholm, M.; Claesson, H.E.: Eoxins are proinflammatory arachidonic acid metabolites produced via the 15-lipoxygenase-1 pathway in human eosinophils and mast cells
Proc. Natl. Acad. Sci. USA
105
680-685
2008
Homo sapiens
Tang, D.G.; Bhatia, B.; Tang, S.; Schneider-Broussard, R.
15-Lipoxygenase 2 (15-LOX2) is a functional tumor suppressor that regulates human prostate epithelial cell differentiation, senescence, and growth (size)
Prostaglandins Other Lipid Mediat.
82
135-146
2007
Homo sapiens (O15296), Homo sapiens
Choi, J.; Chon, J.K.; Kim, S.; Shin, W.
Conformational flexibility in mammalian 15S-lipoxygenase: Reinterpretation of the crystallographic data
Proteins
70
1023-1032
2008
Oryctolagus cuniculus (P12530), Oryctolagus cuniculus
Liu, C.; Xu, D.; Liu, L.; Schain, F.; Brunnstroem, A.; Bjoerkholm, M.; Claesson, H.E.; Sjoeberg, J.
15-Lipoxygenase-1 induces expression and release of chemokines in cultured human lung epithelial cells
Am. J. Physiol. Lung Cell Mol. Physiol.
297
L196-L203
2009
Homo sapiens
Yuan, H.; Lanting, L.; Xu, Z.; Li, S.; Swiderski, P.; Putta, S.; Jonnalagadda, M.; Kato, M.; Natarajan, R.
Effects of cholesterol-tagged small interfering RNAs targeting 12/15-lipoxygenase on parameters of diabetic nephropathy in a mouse model of type 1 diabetes
Am. J. Physiol. Renal Physiol.
295
F605-F617
2008
Mus musculus, Mus musculus DBA/2J
Zhao, J.; Maskrey, B.; Balzar, S.; Chibana, K.; Mustovich, A.; Hu, H.; Trudeau, J.B.; ODonnell, V.; Wenzel, S.E.
Interleukin-13-induced MUC5AC is regulated by 15-lipoxygenase 1 pathway in human bronchial epithelial cells
Am. J. Respir. Crit. Care Med.
179
782-790
2009
Homo sapiens
Nagelin, M.H.; Srinivasan, S.; Lee, J.; Nadler, J.L.; Hedrick, C.C.
12/15-Lipoxygenase activity increases the degradation of macrophage ATP-binding cassette transporter G1
Arterioscler. Thromb. Vasc. Biol.
28
1811-1819
2008
Sus scrofa
Weibel, G.L.; Joshi, M.R.; Alexander, E.T.; Zhu, P.; Blair, I.A.; Rothblat, G.H.
Overexpression of human 15(S)-lipoxygenase-1 in RAW macrophages leads to increased cholesterol mobilization and reverse cholesterol transport
Arterioscler. Thromb. Vasc. Biol.
29
837-842
2009
Homo sapiens
Chabane, N.; Zayed, N.; Benderdour, M.; Martel-Pelletier, J.; Pelletier, J.; Duval, N.; Fahmi, H.
Human articular chondrocytes express 15-lipoxygenase-1 and -2: Potential role in osteoarthritis
Arthritis Res. Ther.
11
R44
2009
Homo sapiens
Gheorghe, K.R.; Korotkova, M.; Catrina, A.I.; Backman, L.; af Klint, E.; Claesson, H.E.; Radmark, O.; Jakobsson, P.J.
Expression of 5-lipoxygenase and 15-lipoxygenase in rheumatoid arthritis synovium and effects of intraarticular glucocorticoids
Arthritis Res. Ther.
11
R83
2009
Homo sapiens
Danielsson, K.; Rydberg, E.; Ingelsten, M.; Akyuerek, L.; Jirholt, P.; Ullstroem, C.; Forsberg, G.; Boren, J.; Wiklund, O.; Hulten, L.
15-Lipoxygenase-2 expression in human macrophages induces chemokine secretion and T cell migration
Atherosclerosis
199
34-40
2008
Homo sapiens
Mei, G.; Di Venere, A.; Nicolai, E.; Angelucci, C.B.; Ivanov, I.; Sabatucci, A.; Dainese, E.; Kuhn, H.; Maccarrone, M.
Structural properties of plant and mammalian lipoxygenases. Temperature-dependent conformational alterations and membrane binding ability
Biochemistry
47
9234-9242
2008
Oryctolagus cuniculus, Glycine max
Wecksler, A.T.; Jacquot, C.; van der Donk, W.A.; Holman, T.R.
Mechanistic investigations of human reticulocyte 15- and platelet 12-lipoxygenases with arachidonic acid
Biochemistry
48
6259-6267
2009
Homo sapiens
Wecksler, A.T.; Kenyon, V.; Garcia, N.K.; Deschamps, J.D.; van der Donk, W.A.; Holman, T.R.
Kinetic and structural investigations of the allosteric site in human epithelial 15-lipoxygenase-2
Biochemistry
48
8721-8730
2009
Homo sapiens
Walther, M.; Roffeis, J.; Jansen, C.; Anton, M.; Ivanov, I.; Kuhn, H.
Structural basis for pH-dependent alterations of reaction specificity of vertebrate lipoxygenase isoforms
Biochim. Biophys. Acta
1791
827-835
2009
Homo sapiens, Mus musculus, Oryctolagus cuniculus
Jacquot, C.; Peng, S.; van der Donk, W.A.
Kinetic isotope effects in the oxidation of arachidonic acid by soybean lipoxygenase-1
Bioorg. Med. Chem. Lett.
18
5959-5962
2008
Glycine max
Yang, Q.; Feng, Y.; Schultz, C.J.; Li, X.A.; Wu, H.; Wang, D.
Synergistic effect of 15-lipoxygenase 2 and radiation in killing head-and-neck cancer
Cancer Gene Ther.
15
323-330
2008
Homo sapiens
Mochizuki, N.; Kwon, Y.
15-Lipoxygenase-1 in the vasculature: Expanding roles in angiogenesis
Circ. Res.
102
143-145
2008
Oryctolagus cuniculus, Homo sapiens
Vrs, K.; Feussner, I.; Khn, H.; Lee, J.; Graner, A.; Lbler, M.; Parthier, B.; Wasternack, C.
Characterization of a methyljasmonate-inducible lipoxygenase from barley (Hordeum vulgare cv. Salome) leaves
Eur. J. Biochem.
251
36-44
1998
Hordeum vulgare (P93184), Hordeum vulgare
Claesson, H.E.; Griffiths, W.J.; Brunnstroem, A.; Schain, F.; Andersson, E.; Feltenmark, S.; Johnson, H.A.; Porwit, A.; Sjoeberg, J.; Bjoerkholm, M.
Hodgkin Reed-Sternberg cells express 15-lipoxygenase-1 and are putative producers of eoxins in vivo: novel insight into the inflammatory features of classical Hodgkin lymphoma
FEBS J.
275
4222-4234
2008
Homo sapiens
Yoo, H.; Jeon, B.; Jeon, M.S.; Lee, H.; Kim, T.Y.
Reciprocal regulation of 12- and 15-lipoxygenases by UV-irradiation in human keratinocytes
FEBS Lett.
582
3249-3253
2008
Homo sapiens
Middleton, M.K.; Zukas, A.M.; Rubinstein, T.; Kinder, M.; Wilson, E.H.; Zhu, P.; Blair, I.A.; Hunter, C.A.; Pure, E.
12/15-lipoxygenase-dependent myeloid production of interleukin-12 is essential for resistance to chronic toxoplasmosis
Infect. Immun.
77
5690-5700
2009
Mus musculus, Mus musculus C57BL/6
Zhu, H.; Glasgow, W.; George, M.D.; Chrysovergis, K.; Olden, K.; Roberts, J.D.; Eling, T.
15-lipoxygenase-1 activates tumor suppressor p53 independent of enzymatic activity
Int. J. Cancer
123
2741-2749
2008
Homo sapiens
Tang, Y.; Wang, M.T.; Chen, Y.; Yang, D.; Che, M.; Honn, K.V.; Akers, G.D.; Johnson, S.R.; Nie, D.
Downregulation of vascular endothelial growth factor and induction of tumor dormancy by 15-lipoxygenase-2 in prostate cancer
Int. J. Cancer
124
1545-1551
2009
Homo sapiens
Dioszeghy, V.; Rosas, M.; Maskrey, B.H.; Colmont, C.; Topley, N.; Chaitidis, P.; Kuehn, H.; Jones, S.A.; Taylor, P.R.; ODonnell, V.B.
12/15-Lipoxygenase regulates the inflammatory response to bacterial products in vivo
J. Immunol.
181
6514-6524
2008
Mus musculus, Mus musculus C57BL/6
Jacquot, C.; McGinley, C.M.; Plata, E.; Holman, T.R.; van der Donk, W.A.
Synthesis of 11-thialinoleic acid and 14-thialinoleic acid, inhibitors of soybean and human lipoxygenases
Org. Biomol. Chem.
6
4242-4252
2008
Homo sapiens
Lang, I.; Feussner, I.
Oxylipin formation in Nostoc punctiforme (PCC73102)
Phytochemistry
68
1120-1127
2007
Nostoc punctiforme (B2IZG6)
Sears, D.D.; Miles, P.D.; Chapman, J.; Ofrecio, J.M.; Almazan, F.; Thapar, D.; Miller, Y.I.
12/15-lipoxygenase is required for the early onset of high fat diet-induced adipose tissue inflammation and insulin resistance in mice
PLoS ONE
4
e7250
2009
Mus musculus, Mus musculus C57BL6
Claesson, H.E.
On the biosynthesis and biological role of eoxins and 15-lipoxygenase-1 in airway inflammation and Hodgkin lymphoma
Prostaglandins Other Lipid Mediat.
89
120-125
2009
Homo sapiens, Mus musculus, Oryctolagus cuniculus, Sus scrofa
Bhattacharya, S.; Mathew, G.; Jayne, D.G.; Pelengaris, S.; Khan, M.
15-lipoxygenase-1 in colorectal cancer: a review
Tumour Biol.
30
185-199
2009
Homo sapiens, Mus musculus, Rattus norvegicus
Whent, M.; Ping, T.; Kenworthy, W.; Yu, L.L.
High-throughput assay for detection of soybean lipoxygenase-1
J. Agric. Food Chem.
58
12602-12607
2010
Glycine max
Andreou, A.; Goebel, C.; Hamberg, M.; Feussner, I.
A bisallylic mini-lipoxygenase from cyanobacterium Cyanothece sp. that has an iron as cofactor
J. Biol. Chem.
285
14178-14186
2010
Crocosphaera subtropica ATCC 51142 (B7JX99), Crocosphaera subtropica ATCC 51142 PCC 8801 (B7JX99)
Rai, G.; Kenyon, V.; Jadhav, A.; Schultz, L.; Armstrong, M.; Jameson, J.B.; Hoobler, E.; Leister, W.; Simeonov, A.; Holman, T.R.; Maloney, D.J.
Discovery of potent and selective inhibitors of human reticulocyte 15-lipoxygenase-1
J. Med. Chem.
53
7392-7404
2010
Homo sapiens
Magnusson, L.U.; Lundqvist, A.; Asp, J.; Synnergren, J.; Johansson, C.T.; Palmqvist, L.; Jeppsson, A.; Hulten, L.M.
High expression of arachidonate 15-lipoxygenase and proinflammatory markers in human ischemic heart tissue
Biochem. Biophys. Res. Commun.
424
327-330
2012
Homo sapiens
Assadieskandar, A.; Amini, M.; Salehi, M.; Sadeghian, H.; Alimardani, M.; Sakhteman, A.; Nadri, H.; Shafiee, A.
Synthesis and SAR study of 4,5-diaryl-1H-imidazole-2(3H)-thione derivatives, as potent 15-lipoxygenase inhibitors
Bioorg. Med. Chem.
20
7160-7166
2012
Glycine max
Schurmann, K.; Anton, M.; Ivanov, I.; Richter, C.; Kuhn, H.; Walther, M.
Molecular basis for the reduced catalytic activity of the naturally occurring T560M mutant of human 12/15-lipoxygenase that has been implicated in coronary artery disease
J. Biol. Chem.
286
23920-23927
2011
Homo sapiens
Toledo, L.; Masgrau, L.; Lluch, J.M.; Gonzalez-Lafont, A.
Substrate binding to mammalian 15-lipoxygenase
J. Comput. Aided Mol. Des.
25
825-835
2011
Oryctolagus cuniculus
Zhao, J.; ODonnell, V.B.; Balzar, S.; St Croix, C.M.; Trudeau, J.B.; Wenzel, S.E.
15-Lipoxygenase 1 interacts with phosphatidylethanolamine-binding protein to regulate MAPK signaling in human airway epithelial cells
Proc. Natl. Acad. Sci. USA
108
14246-14251
2011
Homo sapiens
Deschamps, J.D.; Ogunsola, A.F.; Jameson, J.B.; Yasgar, A.; Flitter, B.A.; Freedman, C.J.; Melvin, J.A.; Nguyen, J.V.; Maloney, D.J.; Jadhav, A.; Simeonov, A.; Bomberger, J.M.; Holman, T.R.
Biochemical and cellular characterization and inhibitor discovery of Pseudomonas aeruginosa 15-lipoxygenase
Biochemistry
55
3329-3340
2016
Pseudomonas aeruginosa (Q9I4G8), Pseudomonas aeruginosa
Droege, K.D.; Keithly, M.E.; Sanders, C.R.; Armstrong, R.N.; Thompson, M.K.
Structural dynamics of 15-lipoxygenase-2 via hydrogen-deuterium exchange
Biochemistry
56
5065-5074
2017
Homo sapiens (O15296)
Ackermann, J.A.; Hofheinz, K.; Zaiss, M.M.; Kroenke, G.
The double-edged role of 12/15-lipoxygenase during inflammation and immunity
Biochim. Biophys. Acta
1862
371-381
2017
Homo sapiens (P16050), Mus musculus (P39654)
Pelcman, B.; Sanin, A.; Nilsson, P.; Schaal, W.; Olofsson, K.; Krog-Jensen, C.; Forsell, P.; Hallberg, A.; Larhed, M.; Boesen, T.; Kromann, H.; Claesson, H.E.
N-Substituted pyrazole-3-carboxamides as inhibitors of human 15-lipoxygenase
Bioorg. Med. Chem. Lett.
25
3017-3023
2015
Homo sapiens (P16050)
Pelcman, B.; Sanin, A.; Nilsson, P.; No, K.; Schaal, W.; Oehrman, S.; Krog-Jensen, C.; Forsell, P.; Hallberg, A.; Larhed, M.; Boesen, T.; Kromann, H.; Vogensen, S.B.; Groth, T.; Claesson, H.E.
3-Substituted pyrazoles and 4-substituted triazoles as inhibitors of human 15-lipoxygenase-1
Bioorg. Med. Chem. Lett.
25
3024-3029
2015
Homo sapiens (P16050)
Tirapegui, C.; Acevedo-Fuentes, W.; Dahech, P.; Torrent, C.; Barrias, P.; Rojas-Poblete, M.; Mascayano, C.
Easy and rapid preparation of benzoylhydrazides and their diazene derivatives as inhibitors of 15-lipoxygenase
Bioorg. Med. Chem. Lett.
27
1649-1653
2017
Homo sapiens (P16050)
Kwon, H.J.; Kim, S.N.; Kim, Y.A.; Lee, Y.H.
The contribution of arachidonate 15-lipoxygenase in tissue macrophages to adipose tissue remodeling
Cell Death Dis.
7
e2285
2016
Mus musculus (P39654)
Suardiaz, R.; Masgrau, L.; Lluch, J.M.; Gonzalez-Lafont, A.
Regio- and stereospecificity in the oxygenation of arachidonic acid catalyzed by Leu597 mutants of rabbit 15-lipoxygenase a QM/MM study
Chemphyschem
15
2303-2310
2014
Oryctolagus cuniculus (P12530)
Suzuki, H.; Kayama, Y.; Sakamoto, M.; Iuchi, H.; Shimizu, I.; Yoshino, T.; Katoh, D.; Nagoshi, T.; Tojo, K.; Minamino, T.; Yoshimura, M.; Utsunomiya, K.
Arachidonate 12/15-lipoxygenase-induced inflammation and oxidative stress are involved in the development of diabetic cardiomyopathy
Diabetes
64
618-630
2015
Mus musculus (P39654), Mus musculus C57BL/6 (P39654)
Tehrani, M.B.; Emami, S.; Asadi, M.; Saeedi, M.; Mirzahekmati, M.; Ebrahimi, S.M.; Mahdavi, M.; Nadri, H.; Moradi, A.; Moghadam, F.H.; Farzipour, S.; Vosooghi, M.; Foroumadi, A.; Shafiee, A.
Imidazo[2,1-b]thiazole derivatives as new inhibitors of 15-lipoxygenase
Eur. J. Med. Chem.
87
759-764
2014
Homo sapiens (P16050)
Ivanov, I.; Kuhn, H.; Heydeck, D.
Structural and functional biology of arachidonic acid 15-lipoxygenase-1 (ALOX15)
Gene
573
1-32
2015
Oryctolagus cuniculus (P12530), Oryctolagus cuniculus, Homo sapiens (P16050), Homo sapiens, Mus musculus (P39654), Mus musculus, Rattus norvegicus (Q02759)
Kundumani-Sridharan, V.; Dyukova, E.; Hansen, D.E.; Rao, G.N.
12/15-Lipoxygenase mediates high-fat diet-induced endothelial tight junction disruption and monocyte transmigration a new role for 15(S)-hydroxyeicosatetraenoic acid in endothelial cell dysfunction
J. Biol. Chem.
288
15830-15842
2013
Mus musculus (P39654), Mus musculus C57BL/6 (P39654)
Chen, Y.; Peng, C.; Abraham, S.A.; Shan, Y.; Guo, Z.; Desouza, N.; Cheloni, G.; Li, D.; Holyoake, T.L.; Li, S.
Arachidonate 15-lipoxygenase is required for chronic myeloid leukemia stem cell survival
J. Clin. Invest.
124
3847-3862
2014
Mus musculus (P39654), Mus musculus
Sun, L.; Xu, Y.W.; Han, J.; Liang, H.; Wang, N.; Cheng, Y.
12/15-Lipoxygenase metabolites of arachidonic acid activate PPARgamma a possible neuroprotective effect in ischemic brain
J. Lipid Res.
56
502-514
2015
Rattus norvegicus (Q02759), Rattus norvegicus Sprague-Dawley (Q02759)
Adel, S.; Karst, F.; Gonzalez-Lafont, A.; Pekarova, M.; Saura, P.; Masgrau, L.; Lluch, J.M.; Stehling, S.; Horn, T.; Kuhn, H.; Heydeck, D.
Evolutionary alteration of ALOX15 specificity optimizes the biosynthesis of antiinflammatory and proresolving lipoxins
Proc. Natl. Acad. Sci. USA
113
E4266-E4275
2016
Homo sapiens (P16050), Homo sapiens neanderthalensis, Homo sapiens subsp. 'Denisova', Macaca mulatta (F7EPQ4), Nomascus leucogenys (G1S6D2), Oryctolagus cuniculus (P12530), Pan paniscus, Pan troglodytes (H2QBX9), Papio anubis (A0A096P2G1), Pongo abelii (Q5RBE8), Pongo pygmaeus (Q5RBE8)
Cole, B.; Lieb, D.; Dobrian, A.; Nadler, J.
12- and 15-lipoxygenases in adipose tissue inflammation
Prostaglandins Other Lipid Mediat.
104-105
84-92
2013
Homo sapiens (P16050)
-
Kumar, N.; Gupta, G.; Anilkumar, K.; Fatima, N.; Karnati, R.; Reddy, G.; Giri, P.; Reddanna, P.
15-Lipoxygenase metabolites of alpha-linolenic acid, [13-(S)-HPOTrE and 13-(S)-HOTrE], mediate anti-inflammatory effects by inactivating NLRP3 inflammasome
Sci. Rep.
6
31649
2016
Mus musculus (P39654), Mus musculus, Mus musculus BALB/c (P39654)
Green, A.R.; Freedman, C.; Tena, J.; Tourdot, B.E.; Liu, B.; Holinstat, M.; Holman, T.R.
5 S,15 S-Dihydroperoxyeicosatetraenoic Acid (5,15-diHpETE) as a lipoxin intermediate Reactivity and kinetics with human leukocyte 5-lipoxygenase, platelet 12-lipoxygenase, and reticulocyte 15-lipoxygenase-1
Biochemistry
57
6726-6734
2018
Homo sapiens (P16050), Homo sapiens
Freedman, C.; Tran, A.; Tourdot, B.E.; Kalyanaraman, C.; Perry, S.; Holinstat, M.; Jacobson, M.P.; Holman, T.R.
Biosynthesis of the maresin intermediate, 13S,14S-epoxy-DHA, by human 15-lipoxygenase and 12-lipoxygenase and its regulation through negative allosteric modulators
Biochemistry
59
1832-1844
2020
Homo sapiens (P16050), Homo sapiens (P18054), Homo sapiens
Perry, S.C.; Horn, T.; Tourdot, B.E.; Yamaguchi, A.; Kalyanaraman, C.; Conrad, W.S.; Akinkugbe, O.; Holinstat, M.; Jacobson, M.P.; Holman, T.R.
Role of human 15-lipoxygenase-2 in the biosynthesis of the lipoxin intermediate, 5S,15S-diHpETE, implicated with the altered positional specificity of human 15-lipoxygenase-1
Biochemistry
59
4118-4130
2020
Homo sapiens (O15296), Homo sapiens (P16050), Homo sapiens (P18054), Homo sapiens
Tsai, W.C.; Gilbert, N.C.; Ohler, A.; Armstrong, M.; Perry, S.; Kalyanaraman, C.; Yasgar, A.; Rai, G.; Simeonov, A.; Jadhav, A.; Standley, M.; Lee, H.W.; Crews, P.; Iavarone, A.T.; Jacobson, M.P.; Neau, D.B.; Offenbacher, A.R.; Newcomer, M.; Holman, T.R.
Kinetic and structural investigations of novel inhibitors of human epithelial 15-lipoxygenase-2
Bioorg. Med. Chem.
46
116349
2021
Homo sapiens (O15296), Homo sapiens
Lee, J.; Kim, T.H.; Oh, D.K.
Bioconversion of arachidonic acid into human 14,15-hepoxilin B3 and 13,14,15-trioxilin B3 by recombinant cells expressing microbial 15-lipoxygenase without and with epoxide hydrolase
Biotechnol. Lett.
42
2001-2009
2020
Archangium violaceum, Archangium violaceum DSM 52858
ElBordiny, H.S.; El-Miligy, M.M.; Kassab, S.E.; Daabees, H.; Mohamed Ali, W.A.; Abdelhamid Mohamed El-Hawash, S.
Design, synthesis, biological evaluation and docking studies of new 3-(4,5-dihydro-1H-pyrazol/isoxazol-5-yl)-2-phenyl-1H-indole derivatives as potent antioxidants and 15-lipoxygenase inhibitors
Eur. J. Med. Chem.
145
594-605
2018
Homo sapiens (O15296)
Ogawa, M.; Ishihara, T.; Isobe, Y.; Kato, T.; Kuba, K.; Imai, Y.; Uchino, Y.; Tsubota, K.; Arita, M.
Eosinophils promote corneal wound healing via the 12/15-lipoxygenase pathway
FASEB J.
34
12492-12501
2020
Mus musculus (P39654)
Miyata, J.; Yokokura, Y.; Moro, K.; Arai, H.; Fukunaga, K.; Arita, M.
12/15-Lipoxygenase regulates IL-33-induced eosinophilic airway inflammation in mice
Front. Immunol.
12
687192
2021
Mus musculus (P39654)
Nagasaki, T.; Schuyler, A.J.; Zhao, J.; Samovich, S.N.; Yamada, K.; Deng, Y.; Ginebaugh, S.P.; Christenson, S.A.; Woodruff, P.G.; Fahy, J.V.; Trudeau, J.B.; Stoyanovsky, D.; Ray, A.; Tyurina, Y.Y.; Kagan, V.E.; Wenzel, S.E.
15LO1 dictates glutathione redox changes in asthmatic airway epithelium to worsen type 2 inflammation
J. Clin. Invest.
132
e151685
2022
Homo sapiens (P16050)
Coppey, L.; Obrosov, A.; Shevalye, H.; Davidson, E.; Paradee, W.; Yorek, M.A.
Characterization of mice ubiquitously overexpressing human 15-lipoxygenase-1 effect of diabetes on peripheral neuropathy and treatment with menhaden oil
J. Diabetes Res.
2021
5564477
2021
Homo sapiens (P16050)
Ali, S.A.; Awad, S.M.; Said, A.M.; Mahgoub, S.; Taha, H.; Ahmed, N.M.
Design, synthesis, molecular modelling and biological evaluation of novel 3-(2-naphthyl)-1-phenyl-1H-pyrazole derivatives as potent antioxidants and 15-lipoxygenase inhibitors
J. Enzyme Inhib. Med. Chem.
35
847-863
2020
Glycine max
Goftari, S.N.; Sadeghian, H.; Bahrami, A.R.; Maleki, F.; Matin, M.M.
Stylosin and some of its synthetic derivatives induce apoptosis in prostate cancer cells as 15-lipoxygenase enzyme inhibitors
Naunyn Schmiedebergs Arch. Pharmacol.
392
1491-1502
2019
Homo sapiens (P16050), Homo sapiens
Archambault, A.S.; Turcotte, C.; Martin, C.; Provost, V.; Larose, M.C.; Laprise, C.; Chakir, J.; Bissonnette, E.; Laviolette, M.; Bosse, Y.; Flamand, N.
Comparison of eight 15-lipoxygenase (LO) inhibitors on the biosynthesis of 15-LO metabolites by human neutrophils and eosinophils
PLoS ONE
13
e0202424
2018
Homo sapiens (O15296), Homo sapiens (P16050), Homo sapiens
Dobrian, A.D.; Huyck, R.W.; Glenn, L.; Gottipati, V.; Haynes, B.A.; Hansson, G.I.; Marley, A.; McPheat, W.L.; Nadler, J.L.
Activation of the 12/15 lipoxygenase pathway accompanies metabolic decline in db/db pre-diabetic mice
Prostaglandins Other Lipid Mediat.
136
23-32
2018
Mus musculus (P39654)
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