Information on EC 1.14.11.10 - pyrimidine-deoxynucleoside 1'-dioxygenase

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The expected taxonomic range for this enzyme is: Rhodotorula glutinis

EC NUMBER
COMMENTARY hide
1.14.11.10
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RECOMMENDED NAME
GeneOntology No.
pyrimidine-deoxynucleoside 1'-dioxygenase
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
2'-deoxyuridine + 2-oxoglutarate + O2 = uracil + 2-deoxyribonolactone + succinate + CO2
show the reaction diagram
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-
-
-
REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
oxidation
-
-
-
-
oxidative decarboxylation
-
-
-
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redox reaction
-
-
-
-
reduction
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-
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SYSTEMATIC NAME
IUBMB Comments
2'-deoxyuridine,2-oxoglutarate:oxygen oxidoreductase (1'-hydroxylating)
Requires Fe(II) and ascorbate. cf. EC 1.14.11.3, pyrimidine-deoxynucleoside 2'-dioxygenase.
CAS REGISTRY NUMBER
COMMENTARY hide
98865-52-2
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ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
2'-deoxy-2'-fluorouridine + 2-oxoglutarate + O2
uracil + 2-fluororibonolactone + succinate + CO2
show the reaction diagram
-
-
-
-
?
2'-deoxyuridine + 2-oxoglutarate + O2
uracil + deoxyribonolactone + succinate + CO2
show the reaction diagram
-
-
-
-
?
uridine + 2-oxoglutarate + O2
ribonolactone + uracil + succinate + CO2
show the reaction diagram
-
-
-
-
?
NATURAL SUBSTRATES
NATURAL PRODUCTS
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
2'-deoxyuridine + 2-oxoglutarate + O2
uracil + deoxyribonolactone + succinate + CO2
show the reaction diagram
-
-
-
-
?
COFACTOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
ascorbate
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requirement
METALS and IONS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
Fe2+
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requirement
SPECIFIC ACTIVITY [µmol/min/mg]
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
pH OPTIMUM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
7.5
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assay at
TEMPERATURE OPTIMUM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
LOCALIZATION
ORGANISM
UNIPROT
COMMENTARY hide
GeneOntology No.
LITERATURE
SOURCE
STORAGE STABILITY
ORGANISM
UNIPROT
LITERATURE
-20°C, stable for at least a month in 0.02 M sodium phosphate buffer, pH 7.5, with 0.1 mM EDTA
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Purification/COMMENTARY
ORGANISM
UNIPROT
LITERATURE