Disease on EC 1.14.11.4 - procollagen-lysine 5-dioxygenase
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Adenocarcinoma of Lung
A collagen glucosyltransferase drives lung adenocarcinoma progression in mice.
Adenocarcinoma of Lung
High expression of JMJD6 predicts unfavorable survival in lung adenocarcinoma.
Adenocarcinoma of Lung
Lysyl hydroxylases are transcription targets for GATA3 driving lung cancer cell metastasis.
Adenocarcinoma of Lung
PCAF-mediated acetylation of transcriptional factor HOXB9 suppresses lung adenocarcinoma progression by targeting oncogenic protein JMJD6.
Adenocarcinoma of Lung
PLOD2 regulated by transcription factor FOXA1 promotes metastasis in NSCLC.
Alkaptonuria
In vitro inhibition of chick embryo lysyl hydroxylase by homogentisic acid. A proposed connective tissue defect in alkaptonuria.
Alopecia
Minoxidil Cannot Be Used To Target Lysyl Hydroxylases during Postnatal Mouse Lung Development: A Cautionary Note.
Alzheimer Disease
Gene expression profiling of peripheral blood leukocytes shows consistent longitudinal downregulation of TOMM40 and upregulation of KIR2DL5A, PLOD1, and SLC2A8 among fast progressors in early Alzheimer's disease.
Aortic Rupture
A substrate preference for the rough endoplasmic reticulum resident protein FKBP22 during collagen biosynthesis.
Arteriovenous Malformations
Procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 (PLOD2) expression in brain arteriovenous malformations (bAVM) and its association with bAVM size.
Azoospermia
Prediction of 3D Protein Structure Based on The Mutation of AKAP3 and PLOD3 Genes in The Case of Non-Obstructive Azoospermia.
Biliary Tract Neoplasms
ASO Author Reflections: Hypoxia-Induced PLOD2 Is a Key Regulator in Epithelial-Mesenchymal Transition and Chemoresistance in Biliary Tract Cancer.
Biliary Tract Neoplasms
Hypoxia-Induced PLOD2 is a Key Regulator in Epithelial-Mesenchymal Transition and Chemoresistance in Biliary Tract Cancer.
Breast Neoplasms
Adipocyte-derived IL-6 and leptin promote breast Cancer metastasis via upregulation of Lysyl Hydroxylase-2 expression.
Breast Neoplasms
Correlation between procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 and breast cancer.
Breast Neoplasms
DT-13 suppresses breast cancer metastasis by modulating PLOD2 in the adipocytes microenvironment.
Breast Neoplasms
Erratum to: JMJD6 is a driver of cellular proliferation and motility and a marker of poor prognosis in breast cancer.
Breast Neoplasms
Identification of disease-promoting stromal components by comparative proteomic and transcriptomic profiling of canine mammary tumors using laser-capture microdissected FFPE tissue.
Breast Neoplasms
JMJD6 induces HOTAIR, an oncogenic lincRNA, by physically interacting with its proximal promoter.
Breast Neoplasms
JMJD6 is a driver of cellular proliferation and motility and a marker of poor prognosis in breast cancer.
Breast Neoplasms
JMJD6 Licenses ER?-Dependent Enhancer and Coding Gene Activation by Modulating the Recruitment of the CARM1/MED12 Co-activator Complex.
Breast Neoplasms
JMJD6 regulates histone H2A.X phosphorylation and promotes autophagy in triple-negative breast cancer cells via a novel tyrosine kinase activity.
Breast Neoplasms
LncRNA ZFPM2-AS1 aggravates the malignant development of breast cancer via upregulating JMJD6.
Breast Neoplasms
Procollagen Lysyl Hydroxylase 2 is Essential for Breast Cancer Metastasis.
Breast Neoplasms
The epigenetic modifier JMJD6 is amplified in mammary tumors and cooperates with c-Myc to enhance cellular transformation, tumor progression, and metastasis.
Breast Neoplasms
Tumor-secreted PAI-1 promotes breast cancer metastasis via the induction of adipocyte-derived collagen remodeling.
Breast Neoplasms
Tumour-associated macrophages drive stromal cell-dependent collagen crosslinking and stiffening to promote breast cancer aggression.
Bronchopulmonary Dysplasia
Deregulation of the lysyl hydroxylase matrix cross-linking system in experimental and clinical bronchopulmonary dysplasia.
Bronchopulmonary Dysplasia
Minoxidil Cannot Be Used To Target Lysyl Hydroxylases during Postnatal Mouse Lung Development: A Cautionary Note.
Bursitis
The roles of Tenascin C and Fibronectin 1 in adhesive capsulitis: a pilot gene expression study.
Carcinogenesis
Association of ECRG4 with PLK1, CDK4, PLOD1 and PLOD2 in esophageal squamous cell carcinoma.
Carcinogenesis
Barrier to autointegration factor 1, procollagen-lysine, 2-oxoglutarate 5-dioxygenase 3, and splicing factor 3b subunit 4 as early-stage cancer decision markers and drivers of hepatocellular carcinoma.
Carcinogenesis
Bifunctional Enzyme JMJD6 Contributes to Multiple Disease Pathogenesis: New Twist on the Old Story.
Carcinogenesis
Elevated expression of JMJD6 is associated with oral carcinogenesis and maintains cancer stemness properties.
Carcinogenesis
High Expression of PLOD1 Drives Tumorigenesis and Affects Clinical Outcome in Gastrointestinal Carcinoma.
Carcinogenesis
JMJD6 Licenses ER?-Dependent Enhancer and Coding Gene Activation by Modulating the Recruitment of the CARM1/MED12 Co-activator Complex.
Carcinogenesis
JMJD6 Promotes Colon Carcinogenesis through Negative Regulation of p53 by Hydroxylation.
Carcinogenesis
JMJD6 promotes melanoma carcinogenesis through regulation of the alternative splicing of PAK1, a key MAPK signaling component.
Carcinogenesis
Jumonji domain-containing 6 (JMJD6) identified as a potential therapeutic target in ovarian cancer.
Carcinogenesis
Knockdown of PLOD3 suppresses the malignant progression of renal cell carcinoma via reducing TWIST1 expression.
Carcinogenesis
MiR-770 inhibits tumorigenesis and EMT by targeting JMJD6 and regulating WNT/?-catenin pathway in non-small cell lung cancer.
Carcinogenesis
PLOD1, a target of miR-34c, contributes to cell growth and metastasis via repressing LATS1 phosphorylation and inactivating Hippo pathway in osteosarcoma.
Carcinogenesis
PLOD2 Is a Potent Prognostic Marker and Associates with Immune Infiltration in Cervical Cancer.
Carcinogenesis
The Collagen-Modifying Enzyme PLOD2 Is Induced and Required during L1-Mediated Colon Cancer Progression.
Carcinogenesis
The epigenetic modifier JMJD6 is amplified in mammary tumors and cooperates with c-Myc to enhance cellular transformation, tumor progression, and metastasis.
Carcinoma
Association of ECRG4 with PLK1, CDK4, PLOD1 and PLOD2 in esophageal squamous cell carcinoma.
Carcinoma
Characterization of a cancer-associated Epstein-Barr virus EBNA1 variant reveals a novel interaction with PLOD1 and PLOD3.
Carcinoma
Elevated expression of JMJD6 is associated with oral carcinogenesis and maintains cancer stemness properties.
Carcinoma
Epigenome screening highlights that JMJD6 confers an epigenetic vulnerability and mediates sunitinib sensitivity in renal cell carcinoma.
Carcinoma
High Expression of PLOD1 Drives Tumorigenesis and Affects Clinical Outcome in Gastrointestinal Carcinoma.
Carcinoma
Hypoxia-induced PLOD1 overexpression contributes to the malignant phenotype of glioblastoma via NF-?B signaling.
Carcinoma
Involvement of microRNA-124 in biological behaviors of laryngeal carcinoma via PLOD2 signaling pathway.
Carcinoma
Jumonji domain-containing protein 6 functions as a marker of head and neck squamous cell carcinoma at advanced stage with no effect on prognosis.
Carcinoma
Knockdown of PLOD3 suppresses the malignant progression of renal cell carcinoma via reducing TWIST1 expression.
Carcinoma
Lysyl hydroxylase 2-induced collagen cross-link switching promotes metastasis in head and neck squamous cell carcinomas.
Carcinoma
PLOD2 Is Essential to Functional Activation of Integrin ?1 for Invasion/Metastasis in Head and Neck Squamous Cell Carcinomas.
Carcinoma
Procollagen-lysine, 2-oxoglutarate 5-dioxygenases 1, 2, and 3 are potential prognostic indicators in patients with clear cell renal cell carcinoma.
Carcinoma
Regulation of the collagen cross-linking enzymes LOXL2 and PLOD2 by tumor-suppressive microRNA-26a/b in renal cell carcinoma.
Carcinoma
Targeted Demethylation of the PLOD2 mRNA Inhibits the Proliferation and Migration of Renal Cell Carcinoma.
Carcinoma
[Expression of PLOD2 in esophageal squamous cell carcinoma and its correlation with invasion and metastasis].
Carcinoma, Hepatocellular
Barrier to autointegration factor 1, procollagen-lysine, 2-oxoglutarate 5-dioxygenase 3, and splicing factor 3b subunit 4 as early-stage cancer decision markers and drivers of hepatocellular carcinoma.
Carcinoma, Hepatocellular
JMJD6 promotes hepatocellular carcinoma carcinogenesis by targeting CDK4.
Carcinoma, Hepatocellular
PLOD2 induced under hypoxia is a novel prognostic factor for hepatocellular carcinoma after curative resection.
Carcinoma, Non-Small-Cell Lung
MiR-770 inhibits tumorigenesis and EMT by targeting JMJD6 and regulating WNT/?-catenin pathway in non-small cell lung cancer.
Carcinoma, Non-Small-Cell Lung
[Mechanism of PLOD2 induced osimertinib resistance in non-small cell lung cancer HCC827 cells].
Carcinoma, Renal Cell
Epigenome screening highlights that JMJD6 confers an epigenetic vulnerability and mediates sunitinib sensitivity in renal cell carcinoma.
Carcinoma, Renal Cell
Knockdown of PLOD3 suppresses the malignant progression of renal cell carcinoma via reducing TWIST1 expression.
Carcinoma, Renal Cell
Procollagen-lysine, 2-oxoglutarate 5-dioxygenases 1, 2, and 3 are potential prognostic indicators in patients with clear cell renal cell carcinoma.
Carcinoma, Renal Cell
Regulation of the collagen cross-linking enzymes LOXL2 and PLOD2 by tumor-suppressive microRNA-26a/b in renal cell carcinoma.
Carcinoma, Renal Cell
Targeted Demethylation of the PLOD2 mRNA Inhibits the Proliferation and Migration of Renal Cell Carcinoma.
Carcinoma, Squamous Cell
Jumonji domain-containing protein 6 functions as a marker of head and neck squamous cell carcinoma at advanced stage with no effect on prognosis.
Carcinoma, Squamous Cell
Lysyl hydroxylase 2-induced collagen cross-link switching promotes metastasis in head and neck squamous cell carcinomas.
Carcinoma, Squamous Cell
PLOD2 Is Essential to Functional Activation of Integrin ?1 for Invasion/Metastasis in Head and Neck Squamous Cell Carcinomas.
Cataract
Lysyl hydroxylase 3 is required for normal lens capsule formation and maintenance of lens epithelium integrity and fate.
Choriocarcinoma
Jumonji Domain Containing Protein 6: A Novel Oxygen Sensor in the Human Placenta.
Colonic Neoplasms
?-catenin-independent regulation of Wnt target genes by RoR2 and ATF2/ATF4 in colon cancer cells.
Colonic Neoplasms
High Expression of PLOD1 Drives Tumorigenesis and Affects Clinical Outcome in Gastrointestinal Carcinoma.
Colonic Neoplasms
JMJD6 Promotes Colon Carcinogenesis through Negative Regulation of p53 by Hydroxylation.
Colonic Neoplasms
Livin promotes colon cancer progression by regulation of H2A.XY39ph via JMJD6.
Colonic Neoplasms
PLOD3 Is Associated with Immune Cell Infiltration and Genomic Instability in Colon Adenocarcinoma.
Colonic Neoplasms
Structural Mechanism of the Oxygenase JMJD6 Recognition by the Extraterminal (ET) Domain of BRD4.
Colonic Neoplasms
The Collagen-Modifying Enzyme PLOD2 Is Induced and Required during L1-Mediated Colon Cancer Progression.
Colorectal Neoplasms
High Expression of PLOD1 Drives Tumorigenesis and Affects Clinical Outcome in Gastrointestinal Carcinoma.
Colorectal Neoplasms
Hypoxia-induced PLOD1 overexpression contributes to the malignant phenotype of glioblastoma via NF-?B signaling.
Colorectal Neoplasms
N-glycoprotein analysis discovers new up-regulated glycoproteins in colorectal cancer tissue.
Colorectal Neoplasms
PLOD2 promotes aerobic glycolysis and cell progression in colorectal cancer by upregulating HK2.
Connective Tissue Diseases
FKBP65-dependent peptidyl-prolyl isomerase activity potentiates the lysyl hydroxylase 2-driven collagen cross-link switch.
Contracture
A novel homozygous 5bp deletion in FKBP10 causes clinically Bruck syndrome in an Indonesian patient.
Contracture
Bruck syndrome 2 variant lacking congenital contractures and involving a novel compound heterozygous PLOD2 mutation.
Contracture
Expanding the Clinical Spectrum of Phenotypes Caused by Pathogenic Variants in PLOD2.
Contracture
Mutations in FKBP10 cause recessive osteogenesis imperfecta and type 1 bruck syndrome.
Contracture
Mutations in FKBP10, which result in Bruck syndrome and recessive forms of osteogenesis imperfecta, inhibit the hydroxylation of telopeptide lysines in bone collagen.
Contracture
Mutations in PLOD2 cause autosomal-recessive connective tissue disorders within the Bruck syndrome-Osteogenesis imperfecta phenotypic spectrum.
Contracture
Orthopedic Manifestations of Bruck Syndrome: A Case Series with Intermediate to Long-term Follow-Up.
Contracture
Phenotypic and molecular characterization of Bruck syndrome (osteogenesis imperfecta with contractures of the large joints) caused by a recessive mutation in PLOD2.
Diabetes Mellitus, Experimental
Glomerular protocollagen lysyl-hydroxylase activity in streptozotocin diabetes.
Diabetes Mellitus, Experimental
The effect of alloxan diabetes on prolyl and lysyl hydroxylase activity in uninflamed and inflamed rat gingiva.
Diabetes Mellitus, Type 1
Thymic epithelial cell-specific deletion of Jmjd6 reduces Aire protein expression and exacerbates disease development in a mouse model of autoimmune diabetes.
Diabetic Nephropathies
Effect of diabetes and insulin on rat renal glomerular protocollagen hydroxylase activities.
DNA Virus Infections
Nuclear hnRNPA2B1 initiates and amplifies the innate immune response to DNA viruses.
Ehlers-Danlos Syndrome
A case of Ehlers-Danlos syndrome type VIA with a novel PLOD1 gene mutation.
Ehlers-Danlos Syndrome
A common duplication in the lysyl hydroxylase gene of patients with Ehlers Danlos syndrome type VI results in preferential stimulation of lysyl hydroxylase activity and mRNA by hydralazine.
Ehlers-Danlos Syndrome
A compound heterozygote patient with Ehlers-Danlos syndrome type VI has a deletion in one allele and a splicing defect in the other allele of the lysyl hydroxylase gene.
Ehlers-Danlos Syndrome
A homozygous stop codon in the lysyl hydroxylase gene in two siblings with Ehlers-Danlos syndrome type VI.
Ehlers-Danlos Syndrome
A large duplication in the gene for lysyl hydroxylase accounts for the type VI variant of Ehlers-Danlos syndrome in two siblings.
Ehlers-Danlos Syndrome
A new Ehlers-Danlos syndrome with craniofacial characteristics, multiple congenital contractures, progressive joint and skin laxity, and multisystem fragility-related manifestations.
Ehlers-Danlos Syndrome
A nonsense codon of exon 14 reduces lysyl hydroxylase mRNA and leads to aberrant RNA splicing in a patient with Ehlers-Danlos syndrome type VI.
Ehlers-Danlos Syndrome
A novel mutation in the lysyl hydroxylase 1 gene causes decreased lysyl hydroxylase activity in an Ehlers-Danlos VIA patient.
Ehlers-Danlos Syndrome
A null-mutated lysyl hydroxylase gene in a compound heterozygote British patient with Ehlers-Danlos syndrome type VI.
Ehlers-Danlos Syndrome
A patient with Ehlers-Danlos syndrome type VI is a compound heterozygote for mutations in the lysyl hydroxylase gene.
Ehlers-Danlos Syndrome
A patient with Ehlers-Danlos syndrome type VI is homozygous for a premature termination codon in exon 14 of the lysyl hydroxylase 1 gene.
Ehlers-Danlos Syndrome
A splice-site mutation that induces exon skipping and reduction in lysyl hydroxylase mRNA levels but does not create a nonsense codon in Ehlers-Danlos syndrome type VI.
Ehlers-Danlos Syndrome
A substrate preference for the rough endoplasmic reticulum resident protein FKBP22 during collagen biosynthesis.
Ehlers-Danlos Syndrome
Adenoviral gene transfer restores lysyl hydroxylase activity in type VI Ehlers-Danlos syndrome.
Ehlers-Danlos Syndrome
Alu-Alu recombination results in a duplication of seven exons in the lysyl hydroxylase gene in a patient with the type VI variant of Ehlers-Danlos syndrome.
Ehlers-Danlos Syndrome
An Ehlers-Danlos syndrome type VIA patient with cystic malformations of the meninges.
Ehlers-Danlos Syndrome
An in vitro model to evaluate the properties of matrices produced by fibroblasts from osteogenesis imperfecta and Ehlers-Danlos Syndrome patients.
Ehlers-Danlos Syndrome
Biochemical characterization of variants of the Ehlers-Danlos syndrome type VI.
Ehlers-Danlos Syndrome
Cloning and characterization of a third human lysyl hydroxylase isoform.
Ehlers-Danlos Syndrome
Defects in the biochemistry of collagen in diseases of connective tissue.
Ehlers-Danlos Syndrome
Deletion of cysteine 369 in lysyl hydroxylase 1 eliminates enzyme activity and causes Ehlers-Danlos syndrome type VI.
Ehlers-Danlos Syndrome
Delineation of dermatan 4-O-sulfotransferase 1 deficient Ehlers-Danlos syndrome: Observation of two additional patients and comprehensive review of 20 reported patients.
Ehlers-Danlos Syndrome
Duplication of seven exons in the lysyl hydroxylase gene is associated with longer forms of a repetitive sequence within the gene and is a common cause for the type VI variant of Ehlers-Danlos syndrome.
Ehlers-Danlos Syndrome
Ehlers Danlos syndrome, kyphoscoliotic type due to Lysyl Hydroxylase 1 deficiency in two children without congenital or early onset kyphoscoliosis.
Ehlers-Danlos Syndrome
Ehlers-Danlos syndrome in two siblings with deficient lysyl hydroxylase activity in cultured skin fibroblasts but only mild hydroxylysine deficit in skin.
Ehlers-Danlos Syndrome
Ehlers-Danlos syndrome type VI results from a nonsense mutation and a splice site-mediated exon-skipping mutation in the lysyl hydroxylase gene.
Ehlers-Danlos Syndrome
Ehlers-Danlos syndrome type VI with normal lysyl hydroxylase activity cannot be explained by a defect in cellular uptake of ascorbic acid.
Ehlers-Danlos Syndrome
Ehlers-Danlos syndrome type VI: clinical manifestations of collagen lysyl hydroxylase deficiency.
Ehlers-Danlos Syndrome
Ehlers-Danlos syndrome type VI: collagen type specificity of defective lysyl hydroxylation in various tissues.
Ehlers-Danlos Syndrome
Ehlers-Danlos syndrome type VI: lysyl hydroxylase deficiency due to a novel point mutation (W612C).
Ehlers-Danlos Syndrome
Genotyping and prenatal assessment of collagen lysyl hydroxylase deficiency in a family with Ehlers-Danlos syndrome type VI.
Ehlers-Danlos Syndrome
Heterogeneous basis of the type VIB form of Ehlers-Danlos syndrome (EDS VIB) that is unrelated to decreased collagen lysyl hydroxylation.
Ehlers-Danlos Syndrome
Human lysyl hydroxylase: purification to homogeneity, partial characterization and comparison of catalytic properties with those of a mutant enzyme from Ehlers-Danlos syndrome type VI fibroblasts.
Ehlers-Danlos Syndrome
Joint and skin laxity with Dandy-Walker malformation and contractures: a distinct recessive syndrome?
Ehlers-Danlos Syndrome
Mutation analysis of the PLOD1 gene: an efficient multistep approach to the molecular diagnosis of the kyphoscoliotic type of Ehlers-Danlos syndrome (EDS VIA).
Ehlers-Danlos Syndrome
Mutational analysis of the lysyl hydroxylase 1 gene (PLOD) in six unrelated patients with Ehlers-Danlos syndrome type VI: prenatal exclusion of this disorder in one family.
Ehlers-Danlos Syndrome
Mutations in the lysyl hydroxylase 1 gene that result in enzyme deficiency and the clinical phenotype of Ehlers-Danlos syndrome type VI.
Ehlers-Danlos Syndrome
Nevo syndrome is allelic to the kyphoscoliotic type of the Ehlers-Danlos syndrome (EDS VIA).
Ehlers-Danlos Syndrome
Novel human pathological mutations. Gene symbol: PLOD1. Disease: Ehlers-Danlos syndrome type VIA, kyphoscoliotic type.
Ehlers-Danlos Syndrome
Phenotypic variability of the kyphoscoliotic type of Ehlers-Danlos syndrome (EDS VIA): clinical, molecular and biochemical delineation.
Ehlers-Danlos Syndrome
Preferential hydroxylation of type IV collagen by lysyl hydroxylase from Ehlers-Danlos syndrome type VI fibroblasts.
Ehlers-Danlos Syndrome
Prenatal exclusion of Ehlers-Danlos syndrome type VI by mutational analysis.
Ehlers-Danlos Syndrome
Structure and expression of the human lysyl hydroxylase gene (PLOD): introns 9 and 16 contain Alu sequences at the sites of recombination in Ehlers-Danlos syndrome type VI patients.
Ehlers-Danlos Syndrome
The first case report of Kyphoscoliotic Ehlers-Danlos syndrome of chinese origin with a novel PLOD1 gene mutation.
Ehlers-Danlos Syndrome
The kyphoscoliotic type of Ehlers-Danlos syndrome (type VI): differential effects on the hydroxylation of lysine in collagens I and II revealed by analysis of cross-linked telopeptides from urine.
Ehlers-Danlos Syndrome
The mRNA and the activity of lysyl hydroxylase are up-regulated by the administration of ascorbate and hydralazine to human skin fibroblasts from a patient with Ehlers-Danlos syndrome type VI.
Ehlers-Danlos Syndrome
Transcriptome Profiling of Primary Skin Fibroblasts Reveal Distinct Molecular Features Between PLOD1- and FKBP14-Kyphoscoliotic Ehlers-Danlos Syndrome.
Ehlers-Danlos Syndrome
Two novel variants in PLOD1 causing hydrocephalus in female newborn with kyphoscoliotic Ehlers-Danlos syndrome.
Ehlers-Danlos Syndrome
[The biochemistry of collagen and the locomotor apparatus. Hereditary diseases of connective tissue and rheumatologic diseases (part 2)]
Endometrial Neoplasms
Hypoxia-induced PLOD2 regulates invasion and epithelial-mesenchymal transition in endometrial carcinoma cells.
Epidermolysis Bullosa Dystrophica
Lysyl Hydroxylase 3 Localizes to Epidermal Basement Membrane and Is Reduced in Patients with Recessive Dystrophic Epidermolysis Bullosa.
Esophageal Squamous Cell Carcinoma
Association of ECRG4 with PLK1, CDK4, PLOD1 and PLOD2 in esophageal squamous cell carcinoma.
Esophageal Squamous Cell Carcinoma
Hypoxia-induced PLOD1 overexpression contributes to the malignant phenotype of glioblastoma via NF-?B signaling.
Esophageal Squamous Cell Carcinoma
[Expression of PLOD2 in esophageal squamous cell carcinoma and its correlation with invasion and metastasis].
Foot-and-Mouth Disease
Analysis of Amino Acid Mutations of the Foot-and-Mouth Disease Virus Serotype O Using both Heparan Sulfate and JMJD6 Receptors.
Foot-and-Mouth Disease
Bifunctional Enzyme JMJD6 Contributes to Multiple Disease Pathogenesis: New Twist on the Old Story.
Gastrointestinal Neoplasms
High Expression of PLOD1 Drives Tumorigenesis and Affects Clinical Outcome in Gastrointestinal Carcinoma.
Genetic Diseases, Inborn
Warmblood Fragile Foal Syndrome causative single nucleotide polymorphism frequency in Warmblood horses in Brazil.
Glioblastoma
Histology-based expression profiling yields novel prognostic markers in human glioblastoma.
Glioblastoma
Hypoxia-induced PLOD1 overexpression contributes to the malignant phenotype of glioblastoma via NF-?B signaling.
Glioblastoma
Overexpression of PLOD3 promotes tumor progression and poor prognosis in gliomas.
Glioblastoma
Procollagen-lysine 2-oxoglutarate 5-dioxygenase 2 promotes hypoxia-induced glioma migration and invasion.
Glioblastoma
Transcription elongation factors represent in vivo cancer dependencies in glioblastoma.
Glioma
Correction: Procollagen-lysine 2-oxoglutarate 5-dioxygenase 2 promotes hypoxia-induced glioma migration and invasion.
Glioma
Hypoxia-induced PLOD1 overexpression contributes to the malignant phenotype of glioblastoma via NF-?B signaling.
Glioma
Hypoxia-induced PLOD2 promotes proliferation, migration and invasion via PI3K/Akt signaling in glioma.
Glioma
Inhibition of JMJD6 expression reduces the proliferation, migration and invasion of neuroglioma stem cells.
Glioma
Procollagen-lysine 2-oxoglutarate 5-dioxygenase 2 promotes hypoxia-induced glioma migration and invasion.
Glioma
The relationship between PLOD1 expression level and glioma prognosis investigated using public databases.
Hearing Loss
A substrate preference for the rough endoplasmic reticulum resident protein FKBP22 during collagen biosynthesis.
Hearing Loss
FKBP14 kyphoscoliotic Ehlers-Danlos Syndrome in adolescent patient: the first Colombian report.
Hepatitis B, Chronic
Regulation of T cell proliferation by JMJD6 and PDGF-BB during chronic hepatitis B infection.
Hydrocephalus
Two novel variants in PLOD1 causing hydrocephalus in female newborn with kyphoscoliotic Ehlers-Danlos syndrome.
Hyperalgesia
Normalizing JMJD6 Expression in Rat Spinal Dorsal Horn Alleviates Hyperalgesia Following Chronic Constriction Injury.
Hyperglycemia
Glomerular protocollagen lysyl-hydroxylase activity in streptozotocin diabetes.
Hypertension
Minoxidil Cannot Be Used To Target Lysyl Hydroxylases during Postnatal Mouse Lung Development: A Cautionary Note.
Infections
Regulation of T cell proliferation by JMJD6 and PDGF-BB during chronic hepatitis B infection.
Iron Deficiencies
JMJD6 Dysfunction Due to Iron Deficiency in Preeclampsia Disrupts Fibronectin Homeostasis Resulting in Diminished Trophoblast Migration.
Joint Instability
The first case report of Kyphoscoliotic Ehlers-Danlos syndrome of chinese origin with a novel PLOD1 gene mutation.
Kidney Neoplasms
Epigenome screening highlights that JMJD6 confers an epigenetic vulnerability and mediates sunitinib sensitivity in renal cell carcinoma.
Kidney Neoplasms
The effect of a novel glycolysis-related gene signature on progression, prognosis and immune microenvironment of renal cell carcinoma.
Laryngeal Neoplasms
PLOD2 contributes to drug resistance in laryngeal cancer by promoting cancer stem cell-like characteristics.
Liver Cirrhosis
A twenty gene-based gene set variation score reflects the pathological progression from cirrhosis to hepatocellular carcinoma.
Liver Cirrhosis
Identification of differentially expressed genes in hepatic HepG2 cells treated with acetaminophen using suppression subtractive hybridization.
Lung Neoplasms
MiR-770 inhibits tumorigenesis and EMT by targeting JMJD6 and regulating WNT/?-catenin pathway in non-small cell lung cancer.
Lung Neoplasms
PLOD3 suppression exerts an anti-tumor effect on human lung cancer cells by modulating the PKC-delta signaling pathway.
Lung Neoplasms
[Mechanism of PLOD2 induced osimertinib resistance in non-small cell lung cancer HCC827 cells].
Lymphatic Metastasis
Correlation between procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 and breast cancer.
Lymphatic Metastasis
Hypoxia-Induced PLOD2 is a Key Regulator in Epithelial-Mesenchymal Transition and Chemoresistance in Biliary Tract Cancer.
Lymphatic Metastasis
[Expression of PLOD2 in esophageal squamous cell carcinoma and its correlation with invasion and metastasis].
Lymphatic Metastasis
[Upregulation of PLOD2 promotes invasion and metastasis of osteosarcoma cells].
Melanoma
JMJD6 promotes melanoma carcinogenesis through regulation of the alternative splicing of PAK1, a key MAPK signaling component.
Mouth Neoplasms
Bifunctional Enzyme JMJD6 Contributes to Multiple Disease Pathogenesis: New Twist on the Old Story.
Mouth Neoplasms
Elevated expression of JMJD6 is associated with oral carcinogenesis and maintains cancer stemness properties.
Muscle Hypotonia
The first case report of Kyphoscoliotic Ehlers-Danlos syndrome of chinese origin with a novel PLOD1 gene mutation.
Muscle Hypotonia
Transcriptome Profiling of Primary Skin Fibroblasts Reveal Distinct Molecular Features Between PLOD1- and FKBP14-Kyphoscoliotic Ehlers-Danlos Syndrome.
Muscular Diseases
A substrate preference for the rough endoplasmic reticulum resident protein FKBP22 during collagen biosynthesis.
Muscular Diseases
FKBP14 kyphoscoliotic Ehlers-Danlos Syndrome in adolescent patient: the first Colombian report.
Myopia
A DNA pooling-based case-control study of myopia candidate genes COL11A1, COL18A1, FBN1, and PLOD1 in a Chinese population.
Neoplasm Metastasis
A collagen glucosyltransferase drives lung adenocarcinoma progression in mice.
Neoplasm Metastasis
A feedback loop between hypoxia and matrix stress relaxation increases oxygen-axis migration and metastasis in sarcoma.
Neoplasm Metastasis
Adipocyte-derived IL-6 and leptin promote breast Cancer metastasis via upregulation of Lysyl Hydroxylase-2 expression.
Neoplasm Metastasis
Association of ECRG4 with PLK1, CDK4, PLOD1 and PLOD2 in esophageal squamous cell carcinoma.
Neoplasm Metastasis
Correlation between procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 and breast cancer.
Neoplasm Metastasis
DT-13 suppresses breast cancer metastasis by modulating PLOD2 in the adipocytes microenvironment.
Neoplasm Metastasis
Global secretome analysis identifies novel mediators of bone metastasis.
Neoplasm Metastasis
Hypermethylation of GNA14 and its tumor-suppressive role in hepatitis B virus-related hepatocellular carcinoma.
Neoplasm Metastasis
Hypoxia and TGF-?1 induced PLOD2 expression improve the migration and invasion of cervical cancer cells by promoting epithelial-to-mesenchymal transition (EMT) and focal adhesion formation.
Neoplasm Metastasis
Hypoxia-Dependent Modification of Collagen Networks Promotes Sarcoma Metastasis.
Neoplasm Metastasis
Hypoxia-Induced PLOD2 is a Key Regulator in Epithelial-Mesenchymal Transition and Chemoresistance in Biliary Tract Cancer.
Neoplasm Metastasis
JMJD6 induces HOTAIR, an oncogenic lincRNA, by physically interacting with its proximal promoter.
Neoplasm Metastasis
Lysyl hydroxylase 2 induces a collagen cross-link switch in tumor stroma.
Neoplasm Metastasis
Lysyl hydroxylase 2-induced collagen cross-link switching promotes metastasis in head and neck squamous cell carcinomas.
Neoplasm Metastasis
Lysyl hydroxylases are transcription targets for GATA3 driving lung cancer cell metastasis.
Neoplasm Metastasis
Overexpression of PLOD3 promotes tumor progression and poor prognosis in gliomas.
Neoplasm Metastasis
PLOD1 Is a Prognostic Biomarker and Mediator of Proliferation and Invasion in Osteosarcoma.
Neoplasm Metastasis
PLOD1, a target of miR-34c, contributes to cell growth and metastasis via repressing LATS1 phosphorylation and inactivating Hippo pathway in osteosarcoma.
Neoplasm Metastasis
PLOD2 Is Essential to Functional Activation of Integrin ?1 for Invasion/Metastasis in Head and Neck Squamous Cell Carcinomas.
Neoplasm Metastasis
PLOD2 regulated by transcription factor FOXA1 promotes metastasis in NSCLC.
Neoplasm Metastasis
PLOD2-driven IL-6/STAT3 signaling promotes the invasion and metastasis of oral squamous cell carcinoma via activation of integrin ?1.
Neoplasm Metastasis
Procollagen Lysyl Hydroxylase 2 is Essential for Breast Cancer Metastasis.
Neoplasm Metastasis
Regulation of the collagen cross-linking enzymes LOXL2 and PLOD2 by tumor-suppressive microRNA-26a/b in renal cell carcinoma.
Neoplasm Metastasis
The Collagen-Modifying Enzyme PLOD2 Is Induced and Required during L1-Mediated Colon Cancer Progression.
Neoplasm Metastasis
The epigenetic modifier JMJD6 is amplified in mammary tumors and cooperates with c-Myc to enhance cellular transformation, tumor progression, and metastasis.
Neoplasm Metastasis
The relationship between PLOD1 expression level and glioma prognosis investigated using public databases.
Neoplasm Metastasis
Tumor-secreted PAI-1 promotes breast cancer metastasis via the induction of adipocyte-derived collagen remodeling.
Neoplasm Metastasis
[Expression of PLOD2 in esophageal squamous cell carcinoma and its correlation with invasion and metastasis].
Neoplasm Metastasis
[Upregulation of PLOD2 promotes invasion and metastasis of osteosarcoma cells].
Neoplasms
111 ALTERATIONS IN BOVINE ENDOMETRIAL MESSENGER AND micro RNA EXPRESSION PROFILE DUE TO CLINICAL ENDOMETRITIS.
Neoplasms
A five-gene signature is a prognostic biomarker in pan-cancer and related with immunologically associated extracellular matrix.
Neoplasms
Aberrantly expressed PLOD1 promotes cancer aggressiveness in bladder cancer: a potential prognostic marker and therapeutic target.
Neoplasms
Adipocyte-derived IL-6 and leptin promote breast Cancer metastasis via upregulation of Lysyl Hydroxylase-2 expression.
Neoplasms
Antibody-mediated blockade of JMJD6 interaction with collagen I exerts antifibrotic and antimetastatic activities.
Neoplasms
ASO Author Reflections: Hypoxia-Induced PLOD2 Is a Key Regulator in Epithelial-Mesenchymal Transition and Chemoresistance in Biliary Tract Cancer.
Neoplasms
Association analysis of bone mineral density and single nucleotide polymorphisms in two candidate genes on chromosome 1p36.
Neoplasms
Barrier to autointegration factor 1, procollagen-lysine, 2-oxoglutarate 5-dioxygenase 3, and splicing factor 3b subunit 4 as early-stage cancer decision markers and drivers of hepatocellular carcinoma.
Neoplasms
Cancer-Associated Fibroblasts Induce a Collagen Cross-link Switch in Tumor Stroma.
Neoplasms
Characterization of a cancer-associated Epstein-Barr virus EBNA1 variant reveals a novel interaction with PLOD1 and PLOD3.
Neoplasms
Comparative study of the haplotype structure and linkage disequilibrium of chromosome 1p36.2 region in the Korean and Japanese populations.
Neoplasms
Correlation between procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 and breast cancer.
Neoplasms
DT-13 suppresses breast cancer metastasis by modulating PLOD2 in the adipocytes microenvironment.
Neoplasms
Elevated expression of JMJD6 is associated with oral carcinogenesis and maintains cancer stemness properties.
Neoplasms
Gene expression patterns for doxorubicin (Adriamycin) and cyclophosphamide (Cytoxan) (AC) response and resistance.
Neoplasms
Gene Regulation Network Analysis on Human Prostate Orthografts Highlights a Potential Role for the JMJD6 Regulon in Clinical Prostate Cancer.
Neoplasms
High Expression of PLOD1 Drives Tumorigenesis and Affects Clinical Outcome in Gastrointestinal Carcinoma.
Neoplasms
Hypermethylation of GNA14 and its tumor-suppressive role in hepatitis B virus-related hepatocellular carcinoma.
Neoplasms
Hypoxia and TGF-?1 induced PLOD2 expression improve the migration and invasion of cervical cancer cells by promoting epithelial-to-mesenchymal transition (EMT) and focal adhesion formation.
Neoplasms
Hypoxia-induced PLOD1 overexpression contributes to the malignant phenotype of glioblastoma via NF-?B signaling.
Neoplasms
Hypoxia-Induced PLOD2 is a Key Regulator in Epithelial-Mesenchymal Transition and Chemoresistance in Biliary Tract Cancer.
Neoplasms
Hypoxia-induced PLOD2 regulates invasion and epithelial-mesenchymal transition in endometrial carcinoma cells.
Neoplasms
Hypoxic stellate cells of pancreatic cancer stroma regulate extracellular matrix fiber organization and cancer cell motility.
Neoplasms
Identification of PLOD Family Genes as Novel Prognostic Biomarkers for Hepatocellular Carcinoma.
Neoplasms
Inhibition of JMJD6 expression reduces the proliferation, migration and invasion of neuroglioma stem cells.
Neoplasms
JMJD6 induces HOTAIR, an oncogenic lincRNA, by physically interacting with its proximal promoter.
Neoplasms
JMJD6 Promotes Colon Carcinogenesis through Negative Regulation of p53 by Hydroxylation.
Neoplasms
Jmjd6, a JmjC Dioxygenase with Many Interaction Partners and Pleiotropic Functions.
Neoplasms
Jumonji Domain Containing Protein 6: A Novel Oxygen Sensor in the Human Placenta.
Neoplasms
Jumonji domain-containing 6 (JMJD6) identified as a potential therapeutic target in ovarian cancer.
Neoplasms
Knockdown of PLOD3 suppresses the malignant progression of renal cell carcinoma via reducing TWIST1 expression.
Neoplasms
KRAB-Induced Heterochromatin Effectively Silences PLOD2 Gene Expression in Somatic Cells and is Resilient to TGF?1 Activation.
Neoplasms
LncRNA ZFPM2-AS1 aggravates the malignant development of breast cancer via upregulating JMJD6.
Neoplasms
LOXL4 knockdown enhances tumor growth and lung metastasis through collagen-dependent extracellular matrix changes in triple-negative breast cancer.
Neoplasms
Lysyl Hydroxylase 2 Is Secreted by Tumor Cells and Can Modify Collagen in the Extracellular Space.
Neoplasms
MiR-770 inhibits tumorigenesis and EMT by targeting JMJD6 and regulating WNT/?-catenin pathway in non-small cell lung cancer.
Neoplasms
Overexpression of PLOD3 promotes tumor progression and poor prognosis in gliomas.
Neoplasms
PLOD1 Is a Prognostic Biomarker and Mediator of Proliferation and Invasion in Osteosarcoma.
Neoplasms
PLOD1 promotes cell growth and aerobic glycolysis by regulating the SOX9/PI3K/Akt/mTOR signaling pathway in gastric cancer.
Neoplasms
PLOD1, a target of miR-34c, contributes to cell growth and metastasis via repressing LATS1 phosphorylation and inactivating Hippo pathway in osteosarcoma.
Neoplasms
PLOD2 contributes to drug resistance in laryngeal cancer by promoting cancer stem cell-like characteristics.
Neoplasms
PLOD2 increases resistance of gastric cancer cells to 5-fluorouracil by upregulating BCRP and inhibiting apoptosis.
Neoplasms
PLOD2 Is a Potent Prognostic Marker and Associates with Immune Infiltration in Cervical Cancer.
Neoplasms
PLOD2 Is Essential to Functional Activation of Integrin ?1 for Invasion/Metastasis in Head and Neck Squamous Cell Carcinomas.
Neoplasms
PLOD2 promotes aerobic glycolysis and cell progression in colorectal cancer by upregulating HK2.
Neoplasms
PLOD3 Is Associated with Immune Cell Infiltration and Genomic Instability in Colon Adenocarcinoma.
Neoplasms
PLOD3 is Upregulated in Gastric Cancer and Correlated with Clinicopathologic Characteristics.
Neoplasms
PLOD3 suppression exerts an anti-tumor effect on human lung cancer cells by modulating the PKC-delta signaling pathway.
Neoplasms
PLODs are overexpressed in ovarian cancer and are associated with gap junctions via connexin 43.
Neoplasms
Procollagen-lysine 2-oxoglutarate 5-dioxygenase 2 promotes hypoxia-induced glioma migration and invasion.
Neoplasms
Prognostic and therapeutic implications of extracellular matrix associated gene signature in renal clear cell carcinoma.
Neoplasms
Targeted Demethylation of the PLOD2 mRNA Inhibits the Proliferation and Migration of Renal Cell Carcinoma.
Neoplasms
The Collagen-Modifying Enzyme PLOD2 Is Induced and Required during L1-Mediated Colon Cancer Progression.
Neoplasms
The epigenetic modifier JMJD6 is amplified in mammary tumors and cooperates with c-Myc to enhance cellular transformation, tumor progression, and metastasis.
Neoplasms
The potential underlying mechanism of the leukemia caused by MLL-fusion and potential treatments.
Neoplasms
The relationship between PLOD1 expression level and glioma prognosis investigated using public databases.
Neoplasms
Tumor-secreted PAI-1 promotes breast cancer metastasis via the induction of adipocyte-derived collagen remodeling.
Neoplasms
Tumour-associated macrophages drive stromal cell-dependent collagen crosslinking and stiffening to promote breast cancer aggression.
Neoplasms
Understanding the molecular mechanism associated with reversal of oral submucous fibrosis targeting hydroxylysine aldehyde-derived collagen cross-links.
Neoplasms
[Expression of PLOD2 in esophageal squamous cell carcinoma and its correlation with invasion and metastasis].
Neuralgia
JMJD6 exerts function in neuropathic pain by regulating NF??B following peripheral nerve injury in rats.
Neuralgia
Normalizing JMJD6 Expression in Rat Spinal Dorsal Horn Alleviates Hyperalgesia Following Chronic Constriction Injury.
Neuralgia
[Wnt3a signaling pathway plays a role in neuropathic pain through epigenetic modification of JMJD6].
Osteogenesis Imperfecta
An in vitro model to evaluate the properties of matrices produced by fibroblasts from osteogenesis imperfecta and Ehlers-Danlos Syndrome patients.
Osteogenesis Imperfecta
Case Report: Exome Sequencing Identified a Novel Compound Heterozygous Variation in PLOD2 Causing Bruck Syndrome Type 2.
Osteogenesis Imperfecta
Defects in the biochemistry of collagen in diseases of connective tissue.
Osteogenesis Imperfecta
Mutations in PLOD2 cause autosomal-recessive connective tissue disorders within the Bruck syndrome-Osteogenesis imperfecta phenotypic spectrum.
Osteogenesis Imperfecta
Phenomics-Based Quantification of CRISPR-Induced Mosaicism in Zebrafish.
Osteoporosis
Association of PLOD1 polymorphisms with bone mineral density in a population-based study of women from the UK.
Osteosarcoma
JMJD6-STAT3Y705ph axis promotes autophagy in osteosarcoma cancer cells by regulating ATG.
Osteosarcoma
PLOD1 Is a Prognostic Biomarker and Mediator of Proliferation and Invasion in Osteosarcoma.
Osteosarcoma
PLOD1 promotes cell growth and aerobic glycolysis by regulating the SOX9/PI3K/Akt/mTOR signaling pathway in gastric cancer.
Osteosarcoma
PLOD1, a target of miR-34c, contributes to cell growth and metastasis via repressing LATS1 phosphorylation and inactivating Hippo pathway in osteosarcoma.
Osteosarcoma
[Upregulation of PLOD2 promotes invasion and metastasis of osteosarcoma cells].
Ovarian Neoplasms
Jumonji domain-containing 6 (JMJD6) identified as a potential therapeutic target in ovarian cancer.
Ovarian Neoplasms
PLODs are overexpressed in ovarian cancer and are associated with gap junctions via connexin 43.
Pancreatic Neoplasms
Hypoxic stellate cells of pancreatic cancer stroma regulate extracellular matrix fiber organization and cancer cell motility.
Peripheral Nerve Injuries
JMJD6 exerts function in neuropathic pain by regulating NF??B following peripheral nerve injury in rats.
Pre-Eclampsia
Compromised JMJD6 histone demethylase activity impacts on VHL gene repression in preeclampsia.
Pre-Eclampsia
JMJD6 Dysfunction Due to Iron Deficiency in Preeclampsia Disrupts Fibronectin Homeostasis Resulting in Diminished Trophoblast Migration.
Pre-Eclampsia
Jumonji Domain Containing Protein 6 Is Decreased in Human Preeclamptic Placentas and Regulates sFLT-1 Splice Variant Production.
Pre-Eclampsia
Jumonji Domain Containing Protein 6: A Novel Oxygen Sensor in the Human Placenta.
Premature Birth
Minoxidil Cannot Be Used To Target Lysyl Hydroxylases during Postnatal Mouse Lung Development: A Cautionary Note.
procollagen c-endopeptidase deficiency
[The biochemistry of collagen and the locomotor apparatus. Hereditary diseases of connective tissue and rheumatologic diseases (part 2)]
procollagen-lysine 5-dioxygenase deficiency
A new Ehlers-Danlos syndrome with craniofacial characteristics, multiple congenital contractures, progressive joint and skin laxity, and multisystem fragility-related manifestations.
procollagen-lysine 5-dioxygenase deficiency
Defects in the biochemistry of collagen in diseases of connective tissue.
procollagen-lysine 5-dioxygenase deficiency
Delineation of dermatan 4-O-sulfotransferase 1 deficient Ehlers-Danlos syndrome: Observation of two additional patients and comprehensive review of 20 reported patients.
procollagen-lysine 5-dioxygenase deficiency
Ehlers Danlos syndrome, kyphoscoliotic type due to Lysyl Hydroxylase 1 deficiency in two children without congenital or early onset kyphoscoliosis.
procollagen-lysine 5-dioxygenase deficiency
Ehlers-Danlos syndrome type VI: clinical manifestations of collagen lysyl hydroxylase deficiency.
procollagen-lysine 5-dioxygenase deficiency
Ehlers-Danlos syndrome type VI: lysyl hydroxylase deficiency due to a novel point mutation (W612C).
procollagen-lysine 5-dioxygenase deficiency
Ehlers-Danlos syndrome type VIB with characteristic facies, decreased curvatures of the spinal column, and joint contractures in two unrelated girls.
procollagen-lysine 5-dioxygenase deficiency
Genotyping and prenatal assessment of collagen lysyl hydroxylase deficiency in a family with Ehlers-Danlos syndrome type VI.
procollagen-lysine 5-dioxygenase deficiency
Inherited human collagen lysyl hydroxylase deficiency: ascorbic acid response.
procollagen-lysine 5-dioxygenase deficiency
Intronic regulation of Aire expression by Jmjd6 for self-tolerance induction in the thymus.
procollagen-lysine 5-dioxygenase deficiency
JMJD6 modulates DNA damage response through downregulating H4K16ac independently of its enzymatic activity.
procollagen-lysine 5-dioxygenase deficiency
Joint and skin laxity with Dandy-Walker malformation and contractures: a distinct recessive syndrome?
procollagen-lysine 5-dioxygenase deficiency
Loss-of-function mutations of CHST14 in a new type of Ehlers-Danlos syndrome.
procollagen-lysine 5-dioxygenase deficiency
Two novel variants in PLOD1 causing hydrocephalus in female newborn with kyphoscoliotic Ehlers-Danlos syndrome.
Prostatic Neoplasms
Gene Regulation Network Analysis on Human Prostate Orthografts Highlights a Potential Role for the JMJD6 Regulon in Clinical Prostate Cancer.
Prostatic Neoplasms
JMJD6 Is a Druggable Oxygenase That Regulates AR-V7 Expression in Prostate Cancer.
Pulmonary Disease, Chronic Obstructive
PLOD3 Is Associated with Immune Cell Infiltration and Genomic Instability in Colon Adenocarcinoma.
Pulmonary Fibrosis
Lysyl hydroxylase 3 increases collagen deposition and promotes pulmonary fibrosis by activating TGF?1/Smad3 and Wnt/?-catenin pathways.
Pulmonary Fibrosis
Lysyl Hydroxylase Inhibition by Minoxidil Blocks Collagen Deposition and Prevents Pulmonary Fibrosis via TGF-??/Smad3 Signaling Pathway.
RNA Virus Infections
JMJD6 negatively regulates cytosolic RNA induced antiviral signaling by recruiting RNF5 to promote activated IRF3 K48 ubiquitination.
Sarcoma
A feedback loop between hypoxia and matrix stress relaxation increases oxygen-axis migration and metastasis in sarcoma.
Sarcoma
Catalytic properties of lysyl hydroxylase from cells synthesizing genetically different collagen types.
Scleroderma, Systemic
Identification of PLOD2 as telopeptide lysyl hydroxylase, an important enzyme in fibrosis.
Scoliosis
Ehlers Danlos syndrome, kyphoscoliotic type due to Lysyl Hydroxylase 1 deficiency in two children without congenital or early onset kyphoscoliosis.
Shoulder Dislocation
Expression analysis of genes involved in collagen cross-linking and its regulation in traumatic anterior shoulder instability.
Squamous Cell Carcinoma of Head and Neck
Elevated expression of JMJD6 is associated with oral carcinogenesis and maintains cancer stemness properties.
Squamous Cell Carcinoma of Head and Neck
Jumonji domain-containing protein 6 functions as a marker of head and neck squamous cell carcinoma at advanced stage with no effect on prognosis.
Squamous Cell Carcinoma of Head and Neck
Lysyl hydroxylase 2-induced collagen cross-link switching promotes metastasis in head and neck squamous cell carcinomas.
Squamous Cell Carcinoma of Head and Neck
PLOD2 Is Essential to Functional Activation of Integrin ?1 for Invasion/Metastasis in Head and Neck Squamous Cell Carcinomas.
Stomach Neoplasms
High Expression of PLOD1 Drives Tumorigenesis and Affects Clinical Outcome in Gastrointestinal Carcinoma.
Stomach Neoplasms
Hypoxia-induced PLOD1 overexpression contributes to the malignant phenotype of glioblastoma via NF-?B signaling.
Stomach Neoplasms
PLOD1 promotes cell growth and aerobic glycolysis by regulating the SOX9/PI3K/Akt/mTOR signaling pathway in gastric cancer.
Stomach Neoplasms
PLOD2 as a potential regulator of peritoneal dissemination in gastric cancer.
Stomach Neoplasms
PLOD2 increases resistance of gastric cancer cells to 5-fluorouracil by upregulating BCRP and inhibiting apoptosis.
Stomach Neoplasms
PLOD3 is Upregulated in Gastric Cancer and Correlated with Clinicopathologic Characteristics.
Triple Negative Breast Neoplasms
Both EZH2 and JMJD6 regulate cell cycle genes in breast cancer.
Triple Negative Breast Neoplasms
JMJD6 regulates histone H2A.X phosphorylation and promotes autophagy in triple-negative breast cancer cells via a novel tyrosine kinase activity.
type ii protein arginine methyltransferase deficiency
PRMT5- mediated symmetric arginine dimethylation is attenuated by mutant huntingtin and is impaired in Huntington's disease (HD).
Urinary Bladder Neoplasms
Aberrantly expressed PLOD1 promotes cancer aggressiveness in bladder cancer: a potential prognostic marker and therapeutic target.
Urinary Bladder Neoplasms
PLOD1 promotes cell growth and aerobic glycolysis by regulating the SOX9/PI3K/Akt/mTOR signaling pathway in gastric cancer.
Urinary Bladder Neoplasms
Tumour-suppressive miRNA-26a-5p and miR-26b-5p inhibit cell aggressiveness by regulating PLOD2 in bladder cancer.
Uterine Cervical Neoplasms
Hypoxia and TGF-?1 induced PLOD2 expression improve the migration and invasion of cervical cancer cells by promoting epithelial-to-mesenchymal transition (EMT) and focal adhesion formation.
Uterine Cervical Neoplasms
PLOD2 Is a Potent Prognostic Marker and Associates with Immune Infiltration in Cervical Cancer.
Vesicular Stomatitis
JMJD6 negatively regulates cytosolic RNA induced antiviral signaling by recruiting RNF5 to promote activated IRF3 K48 ubiquitination.
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