Information on EC 1.14.13.190 - ferruginol synthase

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The expected taxonomic range for this enzyme is: Rosmarinus officinalis

EC NUMBER
COMMENTARY hide
1.14.13.190
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RECOMMENDED NAME
GeneOntology No.
ferruginol synthase
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REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
abieta-8,11,13-triene + NADPH + H+ + O2 = ferruginol + NADP+ + H2O
show the reaction diagram
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REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
hydroxylation
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PATHWAY
BRENDA Link
KEGG Link
MetaCyc Link
carnosate bioynthesis
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Diterpenoid biosynthesis
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Biosynthesis of secondary metabolites
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SYSTEMATIC NAME
IUBMB Comments
miltiradiene,NADPH:oxygen oxidoreductase (ferruginol forming)
The enzyme is found in some members of the Lamiaceae (mint family). The enzyme from Rosmarinus officinalis (rosemary) is involved in biosynthesis of carnosic acid, while the enzyme from the Chinese medicinal herb Salvia miltiorrhiza is involved in the biosynthesis of the tanshinones, abietane-type norditerpenoid naphthoquinones that are the main lipophilic bioactive components found in the plant.
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
abieta-8,11,13-triene + O2
ferruginol + H2O
show the reaction diagram
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abieta-8,11,13-triene is formed spontaneously from miltiradiene. This reaction may be catalyzed by a not yet identified enzyme
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-
?
NATURAL SUBSTRATES
NATURAL PRODUCTS
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
abieta-8,11,13-triene + O2
ferruginol + H2O
show the reaction diagram
-
abieta-8,11,13-triene is formed spontaneously from miltiradiene. This reaction may be catalyzed by a not yet identified enzyme
-
-
?
KM VALUE [mM]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.025
abieta-8,11,13-triene
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pH and temperature not specified in the publication
Cloned/COMMENTARY
ORGANISM
UNIPROT
LITERATURE
expressed in Escherichia coli
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