Information on EC 1.14.13.203 - farnesoate epoxidase

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The expected taxonomic range for this enzyme is: Bombyx mori

EC NUMBER
COMMENTARY hide
1.14.13.203
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RECOMMENDED NAME
GeneOntology No.
farnesoate epoxidase
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REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
(2E,6E)-farnesoate + NADPH + H+ + O2 = juvenile-hormone-III carboxylate + NADP+ + H2O
show the reaction diagram
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PATHWAY
BRENDA Link
KEGG Link
MetaCyc Link
juvenile hormone III biosynthesis II
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Insect hormone biosynthesis
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SYSTEMATIC NAME
IUBMB Comments
(2E,6E)-farnesoate,NADPH:oxygen oxidoreductase
A heme-thiolate protein (cytochrome P-450). The enzyme, found in Lepidoptera (moths and butterflies), is specific for farnesoate (cf. EC 1.14.13.202, methyl farnesoate epoxidase) [1,2]. It is involved in the synthesis of juvenile hormone.
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
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UniProt
Manually annotated by BRENDA team
GENERAL INFORMATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
malfunction
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CYP15C1 is the gene responsible for the dimolting (mod) mutant that undergoes precocious metamorphosis with fewer larval–larval molt. A 68-bp deletion is identified in the mod allele that introduces a premature stop codon in the coding region of CYP15C1
metabolism
the enzyme is involved in the synthesis of juvenile hormone
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
(2E,6E)-farnesoate + NADPH + H+ + O2
juvenile-hormone-III carboxylate + NADP+ + H2O
show the reaction diagram
NATURAL SUBSTRATES
NATURAL PRODUCTS
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
(2E,6E)-farnesoate + NADPH + H+ + O2
juvenile-hormone-III carboxylate + NADP+ + H2O
show the reaction diagram
COFACTOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
cytochrome P-450
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a heme-thiolate protein
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SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE
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the enzyme specifically expressed in the corpus allatum, an endocrine organ that synthesizes and secretes juvenile hormones. CYP15C1 mRNA is constitutively expressed in corpus allatum from the first instar larval to adult stages, even when juvenile-hormone is not synthesized. No apparent differences in levels of CYP15C1 mRNA are observed between males and females during pupal and adult stages
Manually annotated by BRENDA team
Cloned/COMMENTARY
ORGANISM
UNIPROT
LITERATURE
expression in Sf2 or Sf9 cells
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