Information on EC 1.14.13.204 - long-chain acyl-CoA omega-monooxygenase

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The expected taxonomic range for this enzyme is: Petunia x hybrida

EC NUMBER
COMMENTARY hide
1.14.13.204
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RECOMMENDED NAME
GeneOntology No.
long-chain acyl-CoA omega-monooxygenase
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REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
linoleoyl-CoA + NADPH + H+ + O2 = 18-hydroxylinoleoyl-CoA + NADP+ + H2O
show the reaction diagram
(2)
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oleoyl-CoA + NADPH + H+ + O2 = 18-hydroxyoleoyl-CoA + NADP+ + H2O
show the reaction diagram
(1)
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PATHWAY
BRENDA Link
KEGG Link
MetaCyc Link
stigma estolide biosynthesis
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SYSTEMATIC NAME
IUBMB Comments
long-chain acyl-CoA,NADPH:O2 oxidoreductase (omega-hydroxylating)
The enzymes from solanaceous plants are involved in the biosynthesis of stigmatic estolide, a lipid-based polyester that forms a major component of the exudate.
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
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UniProt
Manually annotated by BRENDA team
GENERAL INFORMATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
physiological function
gene CYP86A22 encodes a fatty acyl-CoA omega-hydroxylase involved in estolide biosynthesis in the stigma of Petunia hybrida. omega-Hydroxy fatty acids are essentially absent in the stigmas from 18 of 46 CYP86A22-RNAi transgenic plants and have varying levels of suppression in the remaining 28 plants. Lipids in the 18 CYP86A22-RNAi stigmas are predominantly triacylglycerols and diacylglycerols instead of the estolides
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
oleate + NADPH + H+ + O2
18-hydroxyoleate + NADP+ + H2O
show the reaction diagram
about 6% of the activity with palmitoyl-CoA
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?
oleoyl-CoA + NADPH + H+ + O2
18-hydroxyoleoyl-CoA + NADP+ + H2O
show the reaction diagram
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?
palmitoyl-CoA + NADPH + H+ + O2
16-hydroxypalmitoyl-CoA + NADP+ + H2O
show the reaction diagram
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about 21% of the activity with palmitoyl-CoA
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?
stearoyl-CoA + NADPH + H+ + O2
18-hydroxystearoyl-CoA + NADP+ + H2O
show the reaction diagram
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about 18% of the activity with palmitoyl-CoA
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?
additional information
?
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SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE
expressed predominantly in the developing stigma
Manually annotated by BRENDA team
STORAGE STABILITY
ORGANISM
UNIPROT
LITERATURE
-80°C, stable for at least six months