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Disease on EC 1.14.19.17 - sphingolipid 4-desaturase

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DISEASE
TITLE OF PUBLICATION
LINK TO PUBMED
Alzheimer Disease
Dihydroceramide Desaturase 1 Inhibitors Reduce Amyloid-? Levels in Primary Neurons from an Alzheimer's Disease Transgenic Model.
Amyloidosis
Dihydroceramide Desaturase 1 Inhibitors Reduce Amyloid-? Levels in Primary Neurons from an Alzheimer's Disease Transgenic Model.
Asthma
Current status of allergy prevalence in Germany: Position paper of the Environmental Medicine Commission of the Robert Koch Institute.
Carcinogenesis
SLC14A1 prevents oncometabolite accumulation and recruits HDAC1 to transrepress oncometabolite genes in urothelial carcinoma.
Carcinoma
Dihydroceramide delays cell cycle G1/S transition via activation of ER stress and induction of autophagy.
Overexpression of degenerative spermatocyte homolog 1 up-regulates the expression of cyclin D1 and enhances metastatic efficiency in esophageal carcinoma Eca109 cells.
Carcinoma, Non-Small-Cell Lung
The anti-cancer drug ABTL0812 induces ER stress-mediated cytotoxic autophagy by increasing dihydroceramide levels in cancer cells.
Carcinoma, Squamous Cell
Dihydroceramide desaturase knockdown impacts sphingolipids and apoptosis after photodamage in human head and neck squamous carcinoma cells.
Chickenpox
Vaccine-Preventable Infections in Childcare Workers.
Cholangiocarcinoma
Dihydroceramide desaturase activity in tumors.
Colorectal Neoplasms
M6A methylation of DEGS2, a key ceramide-synthesizing enzyme, is involved in colorectal cancer progression through ceramide synthesis.
Coronary Artery Disease
Second vs. first-generation drug-eluting stents in complex lesions subsets: 3 years' follow-up of ERACI IV study.
Coronary Disease
[Prevalence of myocardial infarction and coronary heart disease in adults aged 40-79 years in Germany: results of the German Health Interview and Examination Survey for Adults (DEGS1)].
Dermatitis, Atopic
Current status of allergy prevalence in Germany: Position paper of the Environmental Medicine Commission of the Robert Koch Institute.
Dermatitis, Contact
Current status of allergy prevalence in Germany: Position paper of the Environmental Medicine Commission of the Robert Koch Institute.
Diabetes Mellitus, Type 2
Lipid environment induces ER stress, TXNIP expression and inflammation in immune cells of individuals with type 2 diabetes.
Dystonia
Recent genetic advances in early-onset dystonia.
Food Hypersensitivity
Current status of allergy prevalence in Germany: Position paper of the Environmental Medicine Commission of the Robert Koch Institute.
Hepatitis A
Vaccine-Preventable Infections in Childcare Workers.
Herpes Zoster
Vaccine-Preventable Infections in Childcare Workers.
HIV Infections
Reconnaissance of the candidate genes involved in the pathogenesis of human immunodeficiency virus and targeted by antiretroviral therapy.
Hypersensitivity
Current status of allergy prevalence in Germany: Position paper of the Environmental Medicine Commission of the Robert Koch Institute.
Hypertension
Ceramide mediates vascular dysfunction in diet-induced obesity by PP2A-mediated dephosphorylation of the eNOS-Akt complex.
Comparing nationwide prevalences of hypertension and depression based on claims data and survey data: An example from Germany.
How to compare cardiovascular disease and risk factors in elderly patients with haemophilia with the general population.
[Blood pressure in Germany 2008-2011: results of the German Health Interview and Examination Survey for Adults (DEGS1)].
Infections
Dihydrosphingomyelin impairs HIV-1 infection by rigidifying liquid-ordered membrane domains.
Infertility, Male
The Des-1 protein, required for central spindle assembly and cytokinesis, is associated with mitochondria along the meiotic spindle apparatus and with the contractile ring during male meiosis in Drosophila melanogaster.
Influenza, Human
[Vaccination coverage in German adults: results of the German Health Interview and Examination Survey for Adults (DEGS1)].
Insulin Resistance
Differential regulation of Dihydroceramide desaturase by palmitate vs. monounsaturated fatty acids:Implications to insulin resistance.
Mechanistic interplay between ceramide and insulin resistance.
Leukoencephalopathies
Loss of the sphingolipid desaturase DEGS1 causes hypomyelinating leukodystrophy.
Lung Neoplasms
The anti-cancer drug ABTL0812 induces ER stress-mediated cytotoxic autophagy by increasing dihydroceramide levels in cancer cells.
Measles
Vaccine-Preventable Infections in Childcare Workers.
Metabolic Diseases
Ablation of dihydroceramide desaturase 1, a therapeutic target for the treatment of metabolic diseases, simultaneously stimulates anabolic and catabolic signaling.
Mumps
Vaccine-Preventable Infections in Childcare Workers.
Myocardial Infarction
Second vs. first-generation drug-eluting stents in complex lesions subsets: 3 years' follow-up of ERACI IV study.
[Prevalence of myocardial infarction and coronary heart disease in adults aged 40-79 years in Germany: results of the German Health Interview and Examination Survey for Adults (DEGS1)].
Neoplasm Metastasis
Cell cycle-coupled expansion of AR activity promotes cancer progression.
M6A methylation of DEGS2, a key ceramide-synthesizing enzyme, is involved in colorectal cancer progression through ceramide synthesis.
Overexpression of degenerative spermatocyte homolog 1 up-regulates the expression of cyclin D1 and enhances metastatic efficiency in esophageal carcinoma Eca109 cells.
Neoplasms
Alkaline ceramidase 2 (ACER2) and its product dihydrosphingosine mediate the cytotoxicity of N-(4-hydroxyphenyl)retinamide in tumor cells.
Association of the key genes in the pathophysiology between the Type 2 diabetes and Lung cancer.
Cationic ceramides and analogues, LCL30 and LCL85, as adjuvants to photodynamic therapy of tumors.
Dihydroceramide desaturase activity in tumors.
Gamma-tocotrienol profoundly alters sphingolipids in cancer cells by inhibition of dihydroceramide desaturase and possibly activation of sphingolipid hydrolysis during prolonged treatment.
M6A methylation of DEGS2, a key ceramide-synthesizing enzyme, is involved in colorectal cancer progression through ceramide synthesis.
Overexpression of degenerative spermatocyte homolog 1 up-regulates the expression of cyclin D1 and enhances metastatic efficiency in esophageal carcinoma Eca109 cells.
The anti-cancer drug ABTL0812 induces ER stress-mediated cytotoxic autophagy by increasing dihydroceramide levels in cancer cells.
[Participation in cancer screening in Germany: results of the German Health Interview and Examination Survey for Adults (DEGS1)].
Nervous System Diseases
DEGS1 variant causes neurological disorder.
DEGS1-associated aberrant sphingolipid metabolism impairs nervous system function in humans.
Neuroblastoma
Cell density dependent reduction of dihydroceramide desaturase activity in neuroblastoma cells.
Involvement of dihydroceramide desaturase in cell cycle progression in human neuroblastoma cells.
Obesity
Increased dihydroceramide/ceramide ratio mediated by defective expression of degs1 impairs adipocyte differentiation and function.
Selective Blood Pressure Screening in the Young: Quantification of Population Wide Underestimation of Elevated Blood Pressure.
[Overweight and obesity in Germany: results of the German Health Interview and Examination Survey for Adults (DEGS1)].
Ovarian Neoplasms
Comprehensive analysis of LASS6 expression and prognostic value in ovarian cancer.
Overweight
[Overweight and obesity in Germany: results of the German Health Interview and Examination Survey for Adults (DEGS1)].
Pancreatic Neoplasms
?-Tocotrienol induces apoptosis in pancreatic cancer cells by upregulation of ceramide synthesis and modulation of sphingolipid transport.
Pediatric Obesity
Selective Blood Pressure Screening in the Young: Quantification of Population Wide Underestimation of Elevated Blood Pressure.
Prostatic Neoplasms
Proteasomal degradation of sphingosine kinase 1 and inhibition of dihydroceramide desaturase by the sphingosine kinase inhibitors, SKi or ABC294640, induces growth arrest in androgen-independent LNCaP-AI prostate cancer cells.
The Sphingosine Kinase 2 Inhibitor ABC294640 Reduces the Growth of Prostate Cancer Cells and Results in Accumulation of Dihydroceramides In Vitro and In Vivo.
Renal Insufficiency
The Prevalence of Renal Failure.
Rhinitis, Allergic, Seasonal
Current status of allergy prevalence in Germany: Position paper of the Environmental Medicine Commission of the Robert Koch Institute.
Rubella
Vaccine-Preventable Infections in Childcare Workers.
Sarcoma
Dihydroceramide desaturase activity in tumors.
Stroke
Second vs. first-generation drug-eluting stents in complex lesions subsets: 3 years' follow-up of ERACI IV study.
[Prevalence of stroke in adults aged 40 to 79 years in Germany: results of the German Health Interview and Examination Survey for Adults (DEGS1)].
Thrombosis
Comparison of the safety between first- and second-generation drug eluting stents Meta-analysis from 19 randomized trials and 16,924 patients.
Vision Disorders
Visual Impairment Is Associated With Depressive Symptoms-Results From the Nationwide German DEGS1 Study.
Whooping Cough
Vaccine-Preventable Infections in Childcare Workers.