Information on EC 1.14.19.24 - acyl-CoA 11-(E)-desaturase

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The enzyme appears in viruses and cellular organisms

EC NUMBER
COMMENTARY hide
1.14.19.24
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RECOMMENDED NAME
GeneOntology No.
acyl-CoA 11-(E)-desaturase
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REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
an acyl-CoA + 2 ferrocytochrome b5 + O2 + 2 H+ = an (11E)-enoyl-CoA + 2 ferricytochrome b5 + 2 H2O
show the reaction diagram
REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
oxidation
-
-
-
-
redox reaction
-
-
-
-
reduction
-
-
-
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PATHWAY
BRENDA Link
KEGG Link
MetaCyc Link
Spodoptera littoralis pheromone biosynthesis
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SYSTEMATIC NAME
IUBMB Comments
acyl-CoA,ferrocytochrome b5:oxygen oxidoreductase (11,12 trans-dehydrogenating)
Involved in sex pheromone synthesis in the Lepidoptera (moths). The enzyme from the moth Spodoptera littoralis prefers 13:0 and 14:0 substrates. The product is formed by the stereospecific removal of the pro-R H at C-11 and the pro-S H at C-12. cf. EC 1.14.19.5, acyl-CoA 11-(Z)-desaturase.
CAS REGISTRY NUMBER
COMMENTARY hide
199543-17-4
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ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
redbanded leafroller moth
UniProt
Manually annotated by BRENDA team
lightbrown apple moth
UniProt
Manually annotated by BRENDA team
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
(9E)-tetradecenoate + acceptor + O2 + H+
(9E,11E)-tetradecadienoate + ?
show the reaction diagram
-
-
-
?
hexadecanoate + acceptor + O2 + H+
(11E)-hexadecenoate + ?
show the reaction diagram
-
-
-
?
myristoyl-CoA + reduced acceptor + O2
(E)-11-tetradecenoyl-CoA + acceptor + 2 H2O
show the reaction diagram
tetradecanoate + acceptor + O2 + H+
(11E)-tetradecenoate + ?
show the reaction diagram
-
-
-
?
tetradecenoyl-CoA + acceptor + O2 + H+
(Z)-11-tetradecenoic acid + (E)-11-tetradecenoic acid + ?
show the reaction diagram
-
product ratio of 6:1 (Z:E)
-
?
additional information
?
-
the enzyme exhibits no activity with C16 and C18 precursor acids
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-
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NATURAL SUBSTRATES
NATURAL PRODUCTS
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
(9E)-tetradecenoate + acceptor + O2 + H+
(9E,11E)-tetradecadienoate + ?
show the reaction diagram
Q95UJ3
-
-
-
?
hexadecanoate + acceptor + O2 + H+
(11E)-hexadecenoate + ?
show the reaction diagram
Q95UJ3
-
-
-
?
myristoyl-CoA + reduced acceptor + O2
(E)-11-tetradecenoyl-CoA + acceptor + 2 H2O
show the reaction diagram
tetradecanoate + acceptor + O2 + H+
(11E)-tetradecenoate + ?
show the reaction diagram
Q95UJ3
-
-
-
?
LOCALIZATION
ORGANISM
UNIPROT
COMMENTARY hide
GeneOntology No.
LITERATURE
SOURCE
Cloned/COMMENTARY
ORGANISM
UNIPROT
LITERATURE
expressed in Saccharomyces cerevisiae strain InvSc1