Reference on EC 1.14.19.3 - acyl-CoA 6-desaturase
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Jeffcoat, R.; Dunton, A.P.; James, A.T.
Evidence for the different responses of delta9-, delta6- and delta5-fatty acyl-CoA desaturases to cytoplasmic proteins
Biochim. Biophys. Acta
528
28-35
1978
Rattus norvegicus
Browse, J.A.; Slack, C.R.
Catalase stimulates linoleate desaturase activity in microsomes from developing linseed cotyledons
FEBS Lett.
131
111-114
1981
Linum usitatissimum, Spinacia oleracea
-
Mahfouz, M.; Johnson, S.; Holman, R.T.
Inhibition of desaturation of palmitic, linoleic and eicosa-8,11,14-trienoic acids in vitro by isomeric cis-octadecenoic acids
Biochim. Biophys. Acta
663
58-68
1981
Rattus norvegicus
Okayasu, T.; Nagao, M.; Ishibashi, T.; Imai, Y.
Purification and partial characterization of linoleoyl-CoA desaturase from rat liver microsomes
Arch. Biochem. Biophys.
206
21-28
1981
Rattus norvegicus, Rattus norvegicus Wistar
Garda, H.A.; Brenner, R.R.
Short chain aliphatic alcohols increase rat-liver microsomal membrane fluidity and affect the activities of some microsomal membrane-bound enzymes
Biochim. Biophys. Acta
769
160-170
1984
Rattus norvegicus, Rattus norvegicus Wistar
Griffiths, G.; Stobart, A.K.; Stymne, S.
DELTA 6- and DELTA 12-desaturase activities and phosphatidic acid formation in microsomal preparations from the developing cotyledons of common borage (Borago officinalis)
Biochem. J.
252
641-647
1988
Borago officinalis
Norman, H.A.; Pillai, P.; St.John, J.B.
In vitro desaturation of monogalactosyldiacylglycerol and phosphatidylcholine molecular species by chloroplast homogenates
Phytochemistry
30
2217-2222
1991
Arabidopsis thaliana, Glycine max, Spinacia oleracea, Arabidopsis thaliana Heynh.
-
Rodriguez, A.; Sarda, P.; Boulot, P.; Leger, C.L.; Descomps, B.
Differential effect of N-ethyl maleimide on delta6-desaturase activity in human fetal liver toward fatty acids of the n-6 and n-3 series
Lipids
34
23-30
1999
Homo sapiens, Rattus norvegicus
Brown, J.E.; Lindsay, R.M.; Riemersma, R.A.
Linoleic acid metabolism in the spontaneously diabetic rat: delta6-desaturase activity vs. product/precursor ratios
Lipids
35
1319-1323
2000
Homo sapiens, Rattus norvegicus
Chuang, L.T.; Thurmond, J.M.; Liu, J.W.; Kirchner, S.J.; Mukerji, P.; Bray, T.M.; Huang, Y.S.
Effect of conjugated linoleic acid on fungal DELTA6-desaturase activity in a transformed yeast system
Lipids
36
139-143
2001
Mortierella alpina
Williard, D.E.; Nwankwo, J.O.; Kaduce, T.L.; Harmon, S.D.; Irons, M.; Moser, H.W.; Raymond, G.V.; Spector, A.A.
Identification of a fatty acid DELTA6-desaturase deficiency in human skin fibroblasts
J. Lipid Res.
42
501-508
2001
Homo sapiens, Mus musculus, Rattus norvegicus
D'Andrea, S.; Guillou, H.; Jan, S.; Catheline, D.; Thibault, J.N.; Bouriel, M.; Rioux, V.; Legrand, P.
The same rat DELTA6-desaturase not only acts on 18- but also on 24-carbon fatty acids in very-long-chain polyunsaturated fatty acid biosynthesis
Biochem. J.
364
49-55
2002
Homo sapiens, Rattus norvegicus, Rattus norvegicus Sprague-Dawley
Ramanadham, S.; Zhang, S.; Ma, Z.; Wohltmann, M.; Bohrer, A.; Hsu, F.F.; Turk, J.
DELTA6-, stearoyl CoA-, and DELTA5-desaturase enzymes are expressed in beta-cells and are altered by increases in exogenous PUFA concentrations
Biochim. Biophys. Acta
1580
40-56
2002
Homo sapiens, Rattus norvegicus
Cahoon, E.B.; Lindqvist, Y.; Schneider, G.; Shanklin, J.
Redesign of soluble fatty acid desaturases from plants from altered substrate specificity and double bond position
Proc. Natl. Acad. Sci. USA
94
4872-4877
1997
Thunbergia alata
Cahoon, E.B.; Coughlan, S.J.; Shanklin, J.
Characterization of a structurally and functionally diverged acyl-acyl carrier protein desaturase from milkweed seed
Plant Mol. Biol.
33
1105-1110
1997
Thunbergia alata
Schultz, D.J.; Suh, M.C.; Ohlrogge, J.B.
Stearoyl-acyl carrier protein and unusual acyl-acyl carrier protein desaturase activities are differentially influenced by ferredoxin
Plant Physiol.
124
681-692
2000
Thunbergia alata
Domergue, F.; Abbadi, A.; Zahringer, U.; Moreau, H.; Heinz, E.
In vivo characterization of the first acyl-CoA DELTA6-desaturase from a member of the plant kingdom, the microalga Ostreococcus tauri
Biochem. J.
389
483-490
2005
Ostreococcus tauri, Ostreococcus tauri (Q4JDG7)
Guillou, H.; D'Andrea, S.; Rioux, V.; Jan, S.; Legrand, P.
The surprising diversity of DELTA6-desaturase substrates
Biochem. Soc. Trans.
32
86-87
2004
Rattus norvegicus
Saether, T.; Tran, T.N.; Rootwelt, H.; Christophersen, B.O.; Haugen, T.B.
Expression and regulation of DELTA5-desaturase, DELTA6-desaturase, stearoyl-coenzyme A (CoA) desaturase 1, and stearoyl-CoA desaturase 2 in rat testis
Biol. Reprod.
69
117-124
2003
Rattus norvegicus
Sakuradani, E.; Shimizu, S.
Gene cloning and functional analysis of a second DELTA6-fatty acid desaturase from an arachidonic acid-producing Mortierella fungus
Biosci. Biotechnol. Biochem.
67
704-711
2003
Mortierella alpina (Q76LW8), Mortierella alpina
Abe, T.; Sakuradani, E.; Asano, T.; Kanamaru, H.; Ioka, Y.; Shimizu, S.
Identification of mutation sites on DELTA6 desaturase genes from Mortierella alpina 1S-4 mutants
Biosci. Biotechnol. Biochem.
69
1021-1024
2005
Mortierella alpina
Zheng, X.; Seiliez, I.; Hastings, N.; Tocher, D.R.; Panserat, S.; Dickson, C.A.; Bergot, P.; Teale, A.J.
Characterization and comparison of fatty acyl DELTA6 desaturase cDNAs from freshwater and marine teleost fish species
Comp. Biochem. Physiol. B
139
269-279
2004
Cyprinus carpio (Q9DEX6), Cyprinus carpio, Oncorhynchus mykiss (Q98SW7), Oncorhynchus mykiss, Scophthalmus maximus, Sparus aurata (Q8AY64)
Sayanova, O.V.; Beaudoin, F.; Michaelson, L.V.; Shewry, P.R.; Napier, J.A.
Identification of primula fatty acid DELTA6-desaturases with n-3 substrate preferences
FEBS Lett.
542
100-104
2003
Primula vialii (Q84KG6), Primula farinosa (Q84KG8)
Na-Ranong, S.; Laoteng, K.; Kittakoop, P.; Tantichareon, M.; Cheevadhanarak, S.
Substrate specificity and preference of DELTA6-desaturase of Mucor rouxii
FEBS Lett.
579
2744-2748
2005
Amylomyces rouxii
Ge, L.; Gordon, J.S.; Hsuan, C.; Stenn, K.; Prouty, S.M.
Identification of the DELTA-6 desaturase of human sebaceous glands: expression and enzyme activity
J. Invest. Dermatol.
120
707-714
2003
Homo sapiens (O95864), Homo sapiens
Zheng, X.; Tocher, D.R.; Dickson, C.A.; Bell, J.G.; Teale, A.J.
Highly unsaturated fatty acid synthesis in vertebrates: new insights with the cloning and characterization of a DELTA6 desaturase of Atlantic salmon
Lipids
40
13-24
2005
Salmo salar (Q6SES0), Salmo salar
Jan, S.; Guillou, H.; D'Andrea, S.; Daval, S.; Bouriel, M.; Rioux, V.; Legrand, P.
Myristic acid increases DELTA6-desaturase activity in cultured rat hepatocytes
Reprod. Nutr. Dev.
44
131-140
2004
Rattus norvegicus
Wang, D.; Li, M.; Wei, D.; Cai, Y.; Zhang, Y.; Xing, L.
Identification and functional characterization of the DELTA 6-fatty acid desaturase gene from Thamnidium elegans
J. Eukaryot. Microbiol.
54
110-117
2007
Thamnidium elegans, Thamnidium elegans (Q58KB0), Thamnidium elegans As.3.2806, Thamnidium elegans As3.2806 (Q58KB0), Thamnidium elegans As3.2806
Hsiao, T.Y.; Holmes, B.; Blanch, H.W.
Identification and functional analysis of a DELTA-6 desaturase from the marine microalga Glossomastix chrysoplasta
Mar. Biotechnol.
9
154-165
2007
Glossomastix chrysoplasta
Kurdrid, P.; Subudhi, S.; Hongsthong, A.; Ruengjitchatchawalya, M.; Tanticharoen, M.
Functional expression of Spirulina-DELTA6 desaturase gene in yeast, Saccharomyces cerevisiae
Mol. Biol. Rep.
32
215-226
2005
Arthrospira platensis, Arthrospira platensis C1
Kurdrid, P.; Subudhi, S.; Cheevadhanarak, S.; Tanticharoen, M.; Hongsthong, A.
Effect of two intermediate electron donors, NADPH and FADH(2), on Spirulina DELTA6-desaturase co-expressed with two different immediate electron donors, cytochrome b5 and ferredoxin, in Escherichia coli
Mol. Biol. Rep.
34
261-266
2006
Arthrospira platensis
Eckert, H.; La Vallee, B.; Schweiger, B.J.; Kinney, A.J.; Cahoon, E.B.; Clemente, T.
Co-expression of the borage DELTA6 desaturase and the Arabidopsis DELTA15 desaturase results in high accumulation of stearidonic acid in the seeds of transgenic soybean
Planta
224
1050-1057
2006
Borago officinalis
Subudhi, S.; Kurdrid, P.; Hongsthong, A.; Sirijuntarut, M.; Cheevadhanarak, S.; Tanticharoen, M.
Isolation and functional characterization of Spirulina D6D gene promoter: role of a putative GntR transcription factor in transcriptional regulation of D6D gene expression
Biochem. Biophys. Res. Commun.
365
643-649
2008
Arthrospira platensis (Q54795), Arthrospira platensis C1 (Q54795)
Das, U.N.
A defect in the activity of DELTA6 and DELTA5 desaturases may be a factor in the initiation and progression of atherosclerosis
Prostaglandins Leukot. Essent. Fatty Acids
76
251-268
2007
Homo sapiens
Li, Y.Y.; Hu, C.B.; Zheng, Y.J.; Xia, X.A.; Xu, W.J.; Wang, S.Q.; Chen, W.Z.; Sun, Z.W.; Huang, J.H.
The effects of dietary fatty acids on liver fatty acid composition and Delta6-desaturase expression differ with ambient salinities in Siganus canaliculatus
Comp. Biochem. Physiol. B
151
183-190
2008
Siganus canaliculatus (B2KKL4), Siganus canaliculatus
Wan, X.; Zhang, Y.; Wang, P.; Huang, F.; Chen, H.; Jiang, M.
Production of gamma-linolenic acid in Pichia pastoris by expression of a Delta-6 desaturase gene from Cunninghamella echinulata
J. Microbiol. Biotechnol.
19
1098-1102
2009
Cunninghamella echinulata (Q3LU33), Cunninghamella echinulata, Cunninghamella echinulata MIAN6 (Q3LU33), Cunninghamella echinulata MIAN6
Lu, H.; Li, J.N.; Chai, Y.R.; Zhang, X.K.
Identification and characterization of a novel delta6-fatty acid desaturase gene from Rhizopus nigricans
Mol. Biol. Rep.
36
2291-2297
2009
Rhizopus stolonifer (Q32VA4)
Vagner, M.; Santigosa, E.
Characterization and modulation of gene expression and enzymatic activity of DELTA-6 desaturase in teleosts: A review
Aquaculture
315
131-143
2011
Dicentrarchus labrax (B2ZE91), Rachycentron canadum (B7U6V1), Gadus morhua (Q4TVM9), Scophthalmus maximus (Q6QDP0), Salmo salar (Q6SES0), Sparus aurata (Q8AY64), Oncorhynchus mykiss (Q98SW7), Cyprinus carpio (Q9DEX6), Danio rerio (Q9DEX7)
Monroig, O.; Zheng, X.; Morais, S.; Leaver, M.J.; Taggart, J.B.; Tocher, D.R.
Multiple genes for functional DELTA6 fatty acyl desaturases (Fad) in Atlantic salmon (Salmo salar L.): gene and cDNA characterization, functional expression, tissue distribution and nutritional regulation
Biochim. Biophys. Acta
1801
1072-1081
2010
Salmo salar (D2KE02), Salmo salar (D2KE03), Salmo salar (Q6SES0), Salmo salar
Kim, S.; Kim, J.; Kim, S.; Roh, K.; Kim, H.; Lee, K.; Jang, Y.; Kwon, M.; Park, J.
Functional characterization of a DELTA 6-desaturase gene from the black seabream (Acanthopagrus schlegeli)
Biotechnol. Lett.
33
1185-1193
2011
Acanthopagrus schlegelii
Reisner, K.; Lehtonen, M.; Storvik, M.; Jantson, T.; Lakso, M.; Callaway, J.C.; Wong, G.
Trans fat diet causes decreased brood size and shortened lifespan in Caenorhabditis elegans DELTA-6-desaturase mutant fat-3
J. Biochem. Mol. Toxicol.
25
269-279
2011
Caenorhabditis elegans
Iskandarov, U.; Khozin-Goldberg, I.; Cohen, Z.
Identification and characterization of DELTA12, DELTA6, and DELTA5 desaturases from the green microalga Parietochloris incisa
Lipids
45
519-530
2010
Lobosphaera incisa
Santigosa, E.; Geay, F.; Tonon, T.; Le Delliou, H.; Kuhl, H.; Reinhardt, R.; Corcos, L.; Cahu, C.; Zambonino-Infante, J.L.; Mazurais, D.
Cloning, tissue expression analysis, and functional characterization of two DELTA6-desaturase variants of sea bass (Dicentrarchus labrax L.)
Mar. Biotechnol.
13
22-31
2011
Dicentrarchus labrax (B1PJR8), Dicentrarchus labrax (B2ZE91)
Huang, S.; Liu, R.; Niu, Y.; Hasi, A.
Cloning and functional characterization of a fatty acid DELTA6-desaturase from Oenothera biennis: Production of alpha-linolenic acid by heterologous expression in Saccharomyces cerevisiae
Russ. J. Plant Physiol.
57
568-573
2010
Oenothera biennis (E1U2Q3)
-
Lu, H.; Zhu, Y.
The thermostability of two kinds of recombinant DELTA6-fatty acid desaturase with different N-terminal sequence lengths in low temperature
Appl. Biochem. Biotechnol.
171
165-172
2013
Rhizopus stolonifer, Rhizopus stolonifer R31.6
Chen, Q.; Nimal, J.; Li, W.; Liu, X.; Cao, W.
Delta-6 desaturase from borage converts linoleic acid to gamma-linolenic acid in HEK293 cells
Biochem. Biophys. Res. Commun.
410
484-488
2011
Borago officinalis (O04353), Borago officinalis
Kim, S.H.; Park, J.S.; Kim, S.Y.; Kim, J.B.; Roh, K.H.; Kim, H.U.; Lee, K.R.; Kim, J.B.
Functional characterization of polyunsaturated fatty acid delta 6-desaturase and elongase genes from the black seabream (Acanthopagrus schlegelii)
Cell Biochem. Biophys.
68
335-346
2013
Acanthopagrus schlegelii
Tanomman, S.; Ketudat-Cairns, M.; Jangprai, A.; Boonanuntanasarn, S.
Characterization of fatty acid delta-6 desaturase gene in Nile tilapia and heterogenous expression in Saccharomyces cerevisiae
Comp. Biochem. Physiol. B
166
148-156
2013
Oreochromis niloticus
Dahmen, J.L.; Olsen, R.; Fahy, D.; Wallis, J.G.; Browse, J.
Cytochrome b5 coexpression increases Tetrahymena thermophila DELTA6 fatty acid desaturase activity in Saccharomyces cerevisiae
Eukaryot. Cell
12
923-931
2013
Tetrahymena thermophila, Tetrahymena thermophila ATCC 30007
Kim, S.H.; Roh, K.H.; Kim, J.B.; Kim, K.S.; Kim, N.S.; Kim, H.U.; Lee, K.R.; Park, J.S.; Kim, J.B.
Isolation and functional characterization of a delta 6-desaturase gene from the pike eel (Muraenesox cinereus)
J. Microbiol.
51
807-813
2013
Muraenesox cinereus (K9L0F6), Muraenesox cinereus, Muraenesox cinereus pike eel (K9L0F6)
Song, L.; Zhang, Y.; Li, S.; Hu, J.; Yin, W.; Chen, Y.; Hao, S.; Wang, B.; Wang, R.; Hu, Z.
Identification of the substrate recognition region in the DELTA6-fatty acid and DELTA8-sphingolipid desaturase by fusion mutagenesis
Planta
239
753-763
2014
Ribes nigrum
Sayanova, O.; Ruiz-Lopez, N.; Haslam, R.P.; Napier, J.A.
The role of DELTA6-desaturase acyl-carrier specificity in the efficient synthesis of long-chain polyunsaturated fatty acids in transgenic plants
Plant Biotechnol. J.
10
195-206
2012
Mus musculus, Salmo salar, Ostreococcus tauri
Girke, T.; Schmidt, H.; Zaehringer, U.; Reski, R.; Heinz, E.
Identification of a novel DELTA6-acyl-group desaturase by targeted gene disruption in Physcomitrella patens
Plant J.
15
39-48
1998
Physcomitrium patens
Shokri, E.; Nematzadeh, G.; Zolala, J.; Nasiri, N.; Kazemi-Tabar, S.; Hosseinpour-Azad, N.
Delta-6 desaturase makes a different fatty acid profile of seed oil in Iranian borage (Echium amoenum Fisch. and Mey.)
Acta Physiol. Plant.
36
2413-2418
2014
Echium amoenum (D2KP14)
-
Park, H.G.; Kothapalli, K.S.D.; Park, W.J.; DeAllie, C.; Liu, L.; Liang, A.; Lawrence, P.; Brenna, J.T.
Palmitic acid (16 0) competes with omega-6 linoleic and omega-3 alpha-linolenic acids for FADS2 mediated DELTA6-desaturation
Biochim. Biophys. Acta
1861
91-97
2016
Papio anubis (B8R1K0)
Jiang, X.; Liu, H.; Niu, Y.; Qi, F.; Zhang, M.; Huang, J.
Functional identification and regulatory analysis of DELTA6-fatty acid desaturase from the oleaginous fungus Mucor sp. EIM-10
Biotechnol. Lett.
39
453-461
2017
Mucor sp. (B3GQC8), Mucor sp. EIM-10 (B3GQC8)
Kim, S.; Park, J.; Kim, S.; Kim, J.; Roh, K.; Kim, H.; Lee, K.; Kim, J.
Functional characterization of polyunsaturated fatty acid delta 6-desaturase and elongase genes from the black seabream (Acanthopagrus schlegelii)
Cell Biochem. Biophys.
68
335-346
2014
Acanthopagrus schlegelii (A0A1S5R926)
-
Geay, F.; Tinti, E.; Mellery, J.; Michaux, C.; Larondelle, Y.; Perpete, E.; Kestemont, P.
Cloning and functional characterization of DELTA6 fatty acid desaturase (FADS2) in Eurasian perch (Perca fluviatilis)
Comp. Biochem. Physiol. B
191
112-125
2016
Perca fluviatilis (A0A0A1E9M5), Perca fluviatilis
Rezapour-Firouzi, S.; Arefhosseini, S.R.; Ebrahimi-Mamaghani, M.; Baradaran, B.; Sadeghihokmabad, E.; Mostafaei, S.; Torbati, M.; Chehreh, M.
Alteration of delta-6-desaturase (FADS2), secretory phospholipase-A2 (sPLA2) enzymes by Hot-nature diet with co-supplemented hemp seed, evening primrose oils intervention in multiple sclerosis patients
Complement. Ther. Med.
23
652-657
2015
Homo sapiens (O95864), Homo sapiens
Wang, Y.D.; Peng, K.C.; Wu, J.L.; Chen, J.Y.
Transgenic expression of salmon DELTA-5 and DELTA-6 desaturase in zebrafish muscle inhibits the growth of Vibrio alginolyticus and affects fish immunomodulatory activity
Fish Shellfish Immunol.
39
223-230
2014
Salmo salar (Q6SES0)
Lopez-Vicario, C.; Gonzalez-Periz, A.; Rius, B.; Moran-Salvador, E.; Garcia-Alonso, V.; Lozano, J.; Bataller, R.; Cofan, M.; Kang, J.; Arroyo, V.; Claria, J.; Titos, E.
Molecular interplay between DELTA5/DELTA6 desaturases and long-chain fatty acids in the pathogenesis of non-alcoholic steatohepatitis
Gut
63
344-355
2014
Mus musculus (F2WWK6)
Yary, T.; Voutilainen, S.; Tuomainen, T.P.; Ruusunen, A.; Nurmi, T.; Virtanen, J.K.
Omega-6 polyunsaturated fatty acids, serum zinc, delta-5- and delta-6-desaturase activities and incident metabolic syndrome
J. Hum. Nutr. Diet.
30
506-514
2017
Homo sapiens (O95864), Homo sapiens
Shi, H.; Chen, H.; Gu, Z.; Song, Y.; Zhang, H.; Chen, W.; Chen, Y.Q.
Molecular mechanism of substrate specificity for delta 6 desaturase from Mortierella alpina and Micromonas pusilla
J. Lipid Res.
56
2309-2321
2015
Micromonas pusilla (A0A172SZR2), Micromonas pusilla, Mortierella alpina (Q70BL2), Mortierella alpina, Mortierella alpina ATCC 32222 (Q70BL2), Micromonas pusilla CCMP 1545 (A0A172SZR2)
Vaittinen, M.; Walle, P.; Kuosmanen, E.; Maennistoe, V.; Kaekelae, P.; Agren, J.; Schwab, U.; Pihlajamaeki, J.
FADS2 genotype regulates delta-6 desaturase activity and inflammation in human adipose tissue
J. Lipid Res.
57
56-65
2016
Homo sapiens (O95864), Homo sapiens
Watanabe, K.; Ohno, M.; Taguchi, M.; Kawamoto, S.; Ono, K.; Aki, T.
Identification of amino acid residues that determine the substrate specificity of mammalian membrane-bound front-end fatty acid desaturases
J. Lipid Res.
57
89-99
2016
Rattus norvegicus (Q9Z122)
Shi, H.; Wu, R.; Zheng, Y.; Yue, X.
Molecular mechanisms underlying catalytic activity of delta 6 desaturase from Glossomastix chrysoplasta and Thalassiosira pseudonana
J. Lipid Res.
59
79-88
2017
Glossomastix chrysoplasta (Q49S39), Thalassiosira pseudonana (Q4G2T1)
Shi, H.; Chen, H.; Gu, Z.; Zhang, H.; Chen, W.; Chen, Y.Q.
Application of a delta-6 desaturase with alpha-linolenic acid preference on eicosapentaenoic acid production in Mortierella alpina
Microb. Cell Fact.
15
117
2016
Micromonas pusilla (C1MKR5), Micromonas pusilla, Mortierella alpina (Q70BL2), Mortierella alpina, Mortierella alpina ATCC 32222 (Q70BL2), Mortierella alpina ATCC 32222, Micromonas pusilla CCMP 1545 (C1MKR5)
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