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(7Z)-octadec-7-enoic acid + ferrocytochrome b5 + O2 + H+
(5Z,7Z)-octadeca-5,7-dienoic acid + ferricytochrome b5 + H2O
-
5% conversion
-
-
?
(8Z,11Z,14Z)-eicosa-8,11,14-trienoyl-[glycerolipid] + ferrocytochrome b5 + O2 + H+
(5Z,8Z,11Z,14Z)-eicosatetra-5,8,11,14-tetraenoyl-[glycerolipid] + ferricytochrome b5 + H2O
-
-
-
?
(8Z,11Z,14Z)-icosa-8,11,14-trienoyl-[glycerolipid] + ferrocytochrome b5 + O2 + H+
(5Z,8Z,11Z,14Z)-icosatetra-5,8,11,14-tetraenoyl-[glycerolipid] + ferricytochrome b5 + H2O
(8Z,11Z,14Z,17Z)-eicosa-8,11,14,17-tetraenoyl-[glycerolipid] + ferrocytochrome b5 + O2 + H+
(5Z,8Z,11Z,14Z,17Z)-eicosa-5,8,11,14,17-pentaenoyl-[glycerolipid] + ferricytochrome b5 + H2O
best substrate
-
-
?
(8Z,11Z,14Z,17Z)-icosa-8,11,14,17-tetraenoyl-[glycerolipid] + ferrocytochrome b5 + O2 + H+
(5Z,8Z,11Z,14Z,17Z)-icosa-5,8,11,14,17-pentaenoyl-[glycerolipid] + ferricytochrome b5 + H2O
an (8Z,11Z,14Z)-icosa-8,11,14-trienoyl-[glycerolipid] + 2 ferrocytochrome b5 + O2 + 2 H+
a (5Z,8Z,11Z,14Z)-icosatetra-5,8,11,14-tetraenoyl-[glycerolipid] + ferricytochrome b5 + 2 H2O
an (8Z,11Z,14Z,17Z)-icosa-8,11,14,17-tetraenoyl-[glycerolipid] + 2 ferrocytochrome b5 + O2 + 2 H+
a (5Z,8Z,11Z,14Z,17Z)-icosa-5,8,11,14,17-pentaenoyl-[glycerolipid] + ferricytochrome b5 + 2 H2O
di-homo-gamma-linolenic acid + ferrocytochrome b5 + O2 + H+
arachidonic acid + ferricytochrome b5 + H2O
-
55% conversion
-
-
?
dihomo-gamma-linolenic acid + ferrocytochrome b5 + O2 + H+
arachidonic acid + ferricytochrome b5 + H2O
eicosa-11,14,17-trienoate + acceptor + O2 + H+
eicosa-5,11,14,17-tetraenoate + ?
-
i.e. juniperoate
-
?
eicosa-11,14,17-trienoic acid + acceptor + O2 + H+
eicosa-5,11,14,17-tetraenoic acid + ?
-
-
i.e. juniperoic acid
-
?
eicosa-11,14,17-trienoyl-CoA + acceptor + O2 + H+
eicosa-5,11,14,17-tetraenoyl-CoA + ?
-
-
i.e. juniperoyl-CoA
-
?
eicosa-11,14-dienoate + acceptor + O2 + H+
eicosa-5,11,14-trienoate + ?
-
i.e. sciadonoate
-
?
eicosa-11,14-dienoic acid + acceptor + O2 + H+
eicosa-5,11,14-trienoic acid + ?
-
-
i.e. sciadonoic acid
-
?
eicosa-11,14-dienoyl-CoA + acceptor + O2 + H+
eicosa-5,11,14-trienoyl-CoA + ?
-
-
i.e. sciadonoyl-CoA
-
?
linoleic acid + ferrocytochrome b5 + O2 + H+
pinolenic acid + ferricytochrome b5 + H2O
oleic acid + ferrocytochrome b5 + O2 + H+
taxoleic acid + ferricytochrome b5 + H2O
additional information
?
-
(8Z,11Z,14Z)-icosa-8,11,14-trienoyl-[glycerolipid] + ferrocytochrome b5 + O2 + H+
(5Z,8Z,11Z,14Z)-icosatetra-5,8,11,14-tetraenoyl-[glycerolipid] + ferricytochrome b5 + H2O
-
-
-
-
?
(8Z,11Z,14Z)-icosa-8,11,14-trienoyl-[glycerolipid] + ferrocytochrome b5 + O2 + H+
(5Z,8Z,11Z,14Z)-icosatetra-5,8,11,14-tetraenoyl-[glycerolipid] + ferricytochrome b5 + H2O
-
-
-
-
?
(8Z,11Z,14Z)-icosa-8,11,14-trienoyl-[glycerolipid] + ferrocytochrome b5 + O2 + H+
(5Z,8Z,11Z,14Z)-icosatetra-5,8,11,14-tetraenoyl-[glycerolipid] + ferricytochrome b5 + H2O
-
-
-
-
?
(8Z,11Z,14Z)-icosa-8,11,14-trienoyl-[glycerolipid] + ferrocytochrome b5 + O2 + H+
(5Z,8Z,11Z,14Z)-icosatetra-5,8,11,14-tetraenoyl-[glycerolipid] + ferricytochrome b5 + H2O
-
-
-
-
?
(8Z,11Z,14Z)-icosa-8,11,14-trienoyl-[glycerolipid] + ferrocytochrome b5 + O2 + H+
(5Z,8Z,11Z,14Z)-icosatetra-5,8,11,14-tetraenoyl-[glycerolipid] + ferricytochrome b5 + H2O
-
-
-
-
?
(8Z,11Z,14Z)-icosa-8,11,14-trienoyl-[glycerolipid] + ferrocytochrome b5 + O2 + H+
(5Z,8Z,11Z,14Z)-icosatetra-5,8,11,14-tetraenoyl-[glycerolipid] + ferricytochrome b5 + H2O
-
-
-
?
(8Z,11Z,14Z)-icosa-8,11,14-trienoyl-[glycerolipid] + ferrocytochrome b5 + O2 + H+
(5Z,8Z,11Z,14Z)-icosatetra-5,8,11,14-tetraenoyl-[glycerolipid] + ferricytochrome b5 + H2O
-
-
-
-
?
(8Z,11Z,14Z)-icosa-8,11,14-trienoyl-[glycerolipid] + ferrocytochrome b5 + O2 + H+
(5Z,8Z,11Z,14Z)-icosatetra-5,8,11,14-tetraenoyl-[glycerolipid] + ferricytochrome b5 + H2O
-
-
-
-
?
(8Z,11Z,14Z)-icosa-8,11,14-trienoyl-[glycerolipid] + ferrocytochrome b5 + O2 + H+
(5Z,8Z,11Z,14Z)-icosatetra-5,8,11,14-tetraenoyl-[glycerolipid] + ferricytochrome b5 + H2O
-
-
-
?
(8Z,11Z,14Z)-icosa-8,11,14-trienoyl-[glycerolipid] + ferrocytochrome b5 + O2 + H+
(5Z,8Z,11Z,14Z)-icosatetra-5,8,11,14-tetraenoyl-[glycerolipid] + ferricytochrome b5 + H2O
-
-
-
-
?
(8Z,11Z,14Z)-icosa-8,11,14-trienoyl-[glycerolipid] + ferrocytochrome b5 + O2 + H+
(5Z,8Z,11Z,14Z)-icosatetra-5,8,11,14-tetraenoyl-[glycerolipid] + ferricytochrome b5 + H2O
-
-
-
-
?
(8Z,11Z,14Z)-icosa-8,11,14-trienoyl-[glycerolipid] + ferrocytochrome b5 + O2 + H+
(5Z,8Z,11Z,14Z)-icosatetra-5,8,11,14-tetraenoyl-[glycerolipid] + ferricytochrome b5 + H2O
-
-
-
-
?
(8Z,11Z,14Z)-icosa-8,11,14-trienoyl-[glycerolipid] + ferrocytochrome b5 + O2 + H+
(5Z,8Z,11Z,14Z)-icosatetra-5,8,11,14-tetraenoyl-[glycerolipid] + ferricytochrome b5 + H2O
-
-
-
-
?
(8Z,11Z,14Z)-icosa-8,11,14-trienoyl-[glycerolipid] + ferrocytochrome b5 + O2 + H+
(5Z,8Z,11Z,14Z)-icosatetra-5,8,11,14-tetraenoyl-[glycerolipid] + ferricytochrome b5 + H2O
-
-
-
-
?
(8Z,11Z,14Z,17Z)-icosa-8,11,14,17-tetraenoyl-[glycerolipid] + ferrocytochrome b5 + O2 + H+
(5Z,8Z,11Z,14Z,17Z)-icosa-5,8,11,14,17-pentaenoyl-[glycerolipid] + ferricytochrome b5 + H2O
-
-
-
-
?
(8Z,11Z,14Z,17Z)-icosa-8,11,14,17-tetraenoyl-[glycerolipid] + ferrocytochrome b5 + O2 + H+
(5Z,8Z,11Z,14Z,17Z)-icosa-5,8,11,14,17-pentaenoyl-[glycerolipid] + ferricytochrome b5 + H2O
-
-
-
-
?
(8Z,11Z,14Z,17Z)-icosa-8,11,14,17-tetraenoyl-[glycerolipid] + ferrocytochrome b5 + O2 + H+
(5Z,8Z,11Z,14Z,17Z)-icosa-5,8,11,14,17-pentaenoyl-[glycerolipid] + ferricytochrome b5 + H2O
-
-
-
-
?
(8Z,11Z,14Z,17Z)-icosa-8,11,14,17-tetraenoyl-[glycerolipid] + ferrocytochrome b5 + O2 + H+
(5Z,8Z,11Z,14Z,17Z)-icosa-5,8,11,14,17-pentaenoyl-[glycerolipid] + ferricytochrome b5 + H2O
-
-
-
-
?
(8Z,11Z,14Z,17Z)-icosa-8,11,14,17-tetraenoyl-[glycerolipid] + ferrocytochrome b5 + O2 + H+
(5Z,8Z,11Z,14Z,17Z)-icosa-5,8,11,14,17-pentaenoyl-[glycerolipid] + ferricytochrome b5 + H2O
-
-
-
?
(8Z,11Z,14Z,17Z)-icosa-8,11,14,17-tetraenoyl-[glycerolipid] + ferrocytochrome b5 + O2 + H+
(5Z,8Z,11Z,14Z,17Z)-icosa-5,8,11,14,17-pentaenoyl-[glycerolipid] + ferricytochrome b5 + H2O
-
-
-
-
?
(8Z,11Z,14Z,17Z)-icosa-8,11,14,17-tetraenoyl-[glycerolipid] + ferrocytochrome b5 + O2 + H+
(5Z,8Z,11Z,14Z,17Z)-icosa-5,8,11,14,17-pentaenoyl-[glycerolipid] + ferricytochrome b5 + H2O
-
-
-
-
?
(8Z,11Z,14Z,17Z)-icosa-8,11,14,17-tetraenoyl-[glycerolipid] + ferrocytochrome b5 + O2 + H+
(5Z,8Z,11Z,14Z,17Z)-icosa-5,8,11,14,17-pentaenoyl-[glycerolipid] + ferricytochrome b5 + H2O
-
-
-
-
?
(8Z,11Z,14Z,17Z)-icosa-8,11,14,17-tetraenoyl-[glycerolipid] + ferrocytochrome b5 + O2 + H+
(5Z,8Z,11Z,14Z,17Z)-icosa-5,8,11,14,17-pentaenoyl-[glycerolipid] + ferricytochrome b5 + H2O
-
-
-
-
?
(8Z,11Z,14Z,17Z)-icosa-8,11,14,17-tetraenoyl-[glycerolipid] + ferrocytochrome b5 + O2 + H+
(5Z,8Z,11Z,14Z,17Z)-icosa-5,8,11,14,17-pentaenoyl-[glycerolipid] + ferricytochrome b5 + H2O
-
-
-
-
?
(8Z,11Z,14Z,17Z)-icosa-8,11,14,17-tetraenoyl-[glycerolipid] + ferrocytochrome b5 + O2 + H+
(5Z,8Z,11Z,14Z,17Z)-icosa-5,8,11,14,17-pentaenoyl-[glycerolipid] + ferricytochrome b5 + H2O
-
-
-
-
?
(8Z,11Z,14Z,17Z)-icosa-8,11,14,17-tetraenoyl-[glycerolipid] + ferrocytochrome b5 + O2 + H+
(5Z,8Z,11Z,14Z,17Z)-icosa-5,8,11,14,17-pentaenoyl-[glycerolipid] + ferricytochrome b5 + H2O
-
-
-
-
?
an (8Z,11Z,14Z)-icosa-8,11,14-trienoyl-[glycerolipid] + 2 ferrocytochrome b5 + O2 + 2 H+
a (5Z,8Z,11Z,14Z)-icosatetra-5,8,11,14-tetraenoyl-[glycerolipid] + ferricytochrome b5 + 2 H2O
-
-
-
?
an (8Z,11Z,14Z)-icosa-8,11,14-trienoyl-[glycerolipid] + 2 ferrocytochrome b5 + O2 + 2 H+
a (5Z,8Z,11Z,14Z)-icosatetra-5,8,11,14-tetraenoyl-[glycerolipid] + ferricytochrome b5 + 2 H2O
(8Z,11Z,14Z)-icosa-8,11,14-trienoate i.e. di-homo-gamma-linolenate. The enzyme contains a cytochrome b5 domain that acts as the direct electron donor to the active site of the desaturase, and does not require an external cytochrome
(5Z,8Z,11Z,14Z)-icosatetra-5,8,11,14-tetraenoate i.e. arachidonate
-
?
an (8Z,11Z,14Z)-icosa-8,11,14-trienoyl-[glycerolipid] + 2 ferrocytochrome b5 + O2 + 2 H+
a (5Z,8Z,11Z,14Z)-icosatetra-5,8,11,14-tetraenoyl-[glycerolipid] + ferricytochrome b5 + 2 H2O
-
-
-
?
an (8Z,11Z,14Z)-icosa-8,11,14-trienoyl-[glycerolipid] + 2 ferrocytochrome b5 + O2 + 2 H+
a (5Z,8Z,11Z,14Z)-icosatetra-5,8,11,14-tetraenoyl-[glycerolipid] + ferricytochrome b5 + 2 H2O
(8Z,11Z,14Z)-icosa-8,11,14-trienoate i.e. di-homo-gamma-linolenate. The enzyme contains a cytochrome b5 domain that acts as the direct electron donor to the active site of the desaturase, and does not require an external cytochrome
(5Z,8Z,11Z,14Z)-icosatetra-5,8,11,14-tetraenoate i.e. arachidonate
-
?
an (8Z,11Z,14Z)-icosa-8,11,14-trienoyl-[glycerolipid] + 2 ferrocytochrome b5 + O2 + 2 H+
a (5Z,8Z,11Z,14Z)-icosatetra-5,8,11,14-tetraenoyl-[glycerolipid] + ferricytochrome b5 + 2 H2O
-
(8Z,11Z,14Z)-icosa-8,11,14-trienoate i.e. di-homo-gamma-linolenate. Expression of the enzyme in Saccharomyces cerevisiae results in the production of the DELTA5-containing fatty acid arachidonic acid in cells that are provided di-homo-gamma-linolenic acid
(5Z,8Z,11Z,14Z)-icosatetra-5,8,11,14-tetraenoate i.e. arachidonate
-
?
an (8Z,11Z,14Z)-icosa-8,11,14-trienoyl-[glycerolipid] + 2 ferrocytochrome b5 + O2 + 2 H+
a (5Z,8Z,11Z,14Z)-icosatetra-5,8,11,14-tetraenoyl-[glycerolipid] + ferricytochrome b5 + 2 H2O
-
-
-
?
an (8Z,11Z,14Z,17Z)-icosa-8,11,14,17-tetraenoyl-[glycerolipid] + 2 ferrocytochrome b5 + O2 + 2 H+
a (5Z,8Z,11Z,14Z,17Z)-icosa-5,8,11,14,17-pentaenoyl-[glycerolipid] + ferricytochrome b5 + 2 H2O
-
-
-
-
?
an (8Z,11Z,14Z,17Z)-icosa-8,11,14,17-tetraenoyl-[glycerolipid] + 2 ferrocytochrome b5 + O2 + 2 H+
a (5Z,8Z,11Z,14Z,17Z)-icosa-5,8,11,14,17-pentaenoyl-[glycerolipid] + ferricytochrome b5 + 2 H2O
-
-
-
?
dihomo-gamma-linolenic acid + ferrocytochrome b5 + O2 + H+
arachidonic acid + ferricytochrome b5 + H2O
-
-
-
-
?
dihomo-gamma-linolenic acid + ferrocytochrome b5 + O2 + H+
arachidonic acid + ferricytochrome b5 + H2O
-
-
-
?
dihomo-gamma-linolenic acid + ferrocytochrome b5 + O2 + H+
arachidonic acid + ferricytochrome b5 + H2O
-
-
-
?
dihomo-gamma-linolenic acid + ferrocytochrome b5 + O2 + H+
arachidonic acid + ferricytochrome b5 + H2O
-
-
-
-
?
linoleic acid + ferrocytochrome b5 + O2 + H+
pinolenic acid + ferricytochrome b5 + H2O
-
-
pinoleinic acid is DELTA5,9,12-18:3
-
?
linoleic acid + ferrocytochrome b5 + O2 + H+
pinolenic acid + ferricytochrome b5 + H2O
-
-
pinoleinic acid is DELTA5,9,12-18:3
-
?
oleic acid + ferrocytochrome b5 + O2 + H+
taxoleic acid + ferricytochrome b5 + H2O
-
-
taxoleic acid is DELTA5,9-18:2
-
?
oleic acid + ferrocytochrome b5 + O2 + H+
taxoleic acid + ferricytochrome b5 + H2O
-
-
taxoleic acid is DELTA5,9-18:2
-
?
additional information
?
-
-
the enzyme catalyzes the introduction of a cis-double bond at the DELTA5 position of a wide range of saturated fatty acids including tetradecanoic acid, pentadecanoic acid, octadecanoic acid, 14-methyl pentadecanoic acid, 15-methylhexadecanoic acid, and 14-methylhexadecanoic acid
-
-
?
additional information
?
-
-
the enzyme catalyzes the introduction of a cis-double bond at the DELTA5 position of a wide range of saturated fatty acids including tetradecanoic acid, pentadecanoic acid, octadecanoic acid, 14-methyl pentadecanoic acid, 15-methylhexadecanoic acid, and 14-methylhexadecanoic acid
-
-
?
additional information
?
-
-
no activity with 20:1DELTA11, 18:2DELTA9,12, and 18:3DELTA9,12,15
-
-
?
additional information
?
-
the encoded enzyme displays DELTA5-desaturase activity on myristic acid to produce Z5-14:acyl, when heterologously expressed in yeast, but is not able to desaturate any other fatty acid (C8-C16)
-
-
?
additional information
?
-
-
the encoded enzyme displays DELTA5-desaturase activity on myristic acid to produce Z5-14:acyl, when heterologously expressed in yeast, but is not able to desaturate any other fatty acid (C8-C16)
-
-
?
additional information
?
-
the encoded enzyme displays DELTA5-desaturase activity on myristic acid to produce Z5-14:acyl, when heterologously expressed in yeast, but is not able to desaturate any other fatty acid (C8-C16)
-
-
?
additional information
?
-
the encoded enzyme displays DELTA5-desaturase activity on myristic acid to produce Z5-14:acyl, when heterologously expressed in yeast, but is not able to desaturate any other fatty acid (C8-C16)
-
-
?
additional information
?
-
-
the encoded enzyme displays DELTA5-desaturase activity on myristic acid to produce Z5-14:acyl, when heterologously expressed in yeast, but is not able to desaturate any other fatty acid (C8-C16)
-
-
?
additional information
?
-
the encoded enzyme displays DELTA5-desaturase activity on myristic acid to produce Z5-14:acyl, when heterologously expressed in yeast, but is not able to desaturate any other fatty acid (C8C16)
-
-
?
additional information
?
-
the encoded enzyme displays DELTA5-desaturase activity on myristic acid to produce Z5-14:acyl, when heterologously expressed in yeast, but is not able to desaturate any other fatty acid (C8C16)
-
-
?
additional information
?
-
-
the encoded enzyme displays DELTA5-desaturase activity on myristic acid to produce Z5-14:acyl, when heterologously expressed in yeast, but is not able to desaturate any other fatty acid (C8C16)
-
-
?
additional information
?
-
no activity with 18:3(n-3)
-
-
?
additional information
?
-
-
no activity with 18:3(n-3)
-
-
?
additional information
?
-
the enzyme can desaturate C20:4(n-3) and C20:3(n-6) to C20:5(n-3) and C20:4(n-6) respectively, displaying a DELTA5 desaturation activity
-
-
?
additional information
?
-
no activity with 18:2(DELTA9,12), 18:3n-3(DELTA9,12,15), or 22:5n-3(DELTA7,11,13,16,19)
-
-
?
additional information
?
-
expression of the fasd2b in yeast generates a protein that converts eicosatetraenoic acid (20:4n-3) to eicosapentaenoic acid (20:5n-3), and functions as a monofunctional DELTA5 desaturase. The enzyme does not show any DELTA8 desaturase activity
-
-
?
additional information
?
-
-
expression of the fasd2b in yeast generates a protein that converts eicosatetraenoic acid (20:4n-3) to eicosapentaenoic acid (20:5n-3), and functions as a monofunctional DELTA5 desaturase. The enzyme does not show any DELTA8 desaturase activity
-
-
?
additional information
?
-
-
no products are detected with the C18 fatty acid linoleic and gamma-linolenic acids or with the C22 fatty acid adrenic and docosapentaenoic acids
-
-
?
additional information
?
-
-
no activity with 18:3(n-3)
-
-
?
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
(8Z,11Z,14Z)-eicosa-8,11,14-trienoyl-[glycerolipid] + ferrocytochrome b5 + O2 + H+
(5Z,8Z,11Z,14Z)-eicosatetra-5,8,11,14-tetraenoyl-[glycerolipid] + ferricytochrome b5 + H2O
-
-
-
?
(8Z,11Z,14Z)-icosa-8,11,14-trienoyl-[glycerolipid] + ferrocytochrome b5 + O2 + H+
(5Z,8Z,11Z,14Z)-icosatetra-5,8,11,14-tetraenoyl-[glycerolipid] + ferricytochrome b5 + H2O
(8Z,11Z,14Z,17Z)-eicosa-8,11,14,17-tetraenoyl-[glycerolipid] + ferrocytochrome b5 + O2 + H+
(5Z,8Z,11Z,14Z,17Z)-eicosa-5,8,11,14,17-pentaenoyl-[glycerolipid] + ferricytochrome b5 + H2O
best substrate
-
-
?
(8Z,11Z,14Z,17Z)-icosa-8,11,14,17-tetraenoyl-[glycerolipid] + ferrocytochrome b5 + O2 + H+
(5Z,8Z,11Z,14Z,17Z)-icosa-5,8,11,14,17-pentaenoyl-[glycerolipid] + ferricytochrome b5 + H2O
an (8Z,11Z,14Z)-icosa-8,11,14-trienoyl-[glycerolipid] + 2 ferrocytochrome b5 + O2 + 2 H+
a (5Z,8Z,11Z,14Z)-icosatetra-5,8,11,14-tetraenoyl-[glycerolipid] + ferricytochrome b5 + 2 H2O
dihomo-gamma-linolenic acid + ferrocytochrome b5 + O2 + H+
arachidonic acid + ferricytochrome b5 + H2O
(8Z,11Z,14Z)-icosa-8,11,14-trienoyl-[glycerolipid] + ferrocytochrome b5 + O2 + H+
(5Z,8Z,11Z,14Z)-icosatetra-5,8,11,14-tetraenoyl-[glycerolipid] + ferricytochrome b5 + H2O
-
-
-
-
?
(8Z,11Z,14Z)-icosa-8,11,14-trienoyl-[glycerolipid] + ferrocytochrome b5 + O2 + H+
(5Z,8Z,11Z,14Z)-icosatetra-5,8,11,14-tetraenoyl-[glycerolipid] + ferricytochrome b5 + H2O
-
-
-
-
?
(8Z,11Z,14Z)-icosa-8,11,14-trienoyl-[glycerolipid] + ferrocytochrome b5 + O2 + H+
(5Z,8Z,11Z,14Z)-icosatetra-5,8,11,14-tetraenoyl-[glycerolipid] + ferricytochrome b5 + H2O
-
-
-
-
?
(8Z,11Z,14Z)-icosa-8,11,14-trienoyl-[glycerolipid] + ferrocytochrome b5 + O2 + H+
(5Z,8Z,11Z,14Z)-icosatetra-5,8,11,14-tetraenoyl-[glycerolipid] + ferricytochrome b5 + H2O
-
-
-
-
?
(8Z,11Z,14Z)-icosa-8,11,14-trienoyl-[glycerolipid] + ferrocytochrome b5 + O2 + H+
(5Z,8Z,11Z,14Z)-icosatetra-5,8,11,14-tetraenoyl-[glycerolipid] + ferricytochrome b5 + H2O
-
-
-
-
?
(8Z,11Z,14Z)-icosa-8,11,14-trienoyl-[glycerolipid] + ferrocytochrome b5 + O2 + H+
(5Z,8Z,11Z,14Z)-icosatetra-5,8,11,14-tetraenoyl-[glycerolipid] + ferricytochrome b5 + H2O
-
-
-
?
(8Z,11Z,14Z)-icosa-8,11,14-trienoyl-[glycerolipid] + ferrocytochrome b5 + O2 + H+
(5Z,8Z,11Z,14Z)-icosatetra-5,8,11,14-tetraenoyl-[glycerolipid] + ferricytochrome b5 + H2O
-
-
-
-
?
(8Z,11Z,14Z)-icosa-8,11,14-trienoyl-[glycerolipid] + ferrocytochrome b5 + O2 + H+
(5Z,8Z,11Z,14Z)-icosatetra-5,8,11,14-tetraenoyl-[glycerolipid] + ferricytochrome b5 + H2O
-
-
-
-
?
(8Z,11Z,14Z)-icosa-8,11,14-trienoyl-[glycerolipid] + ferrocytochrome b5 + O2 + H+
(5Z,8Z,11Z,14Z)-icosatetra-5,8,11,14-tetraenoyl-[glycerolipid] + ferricytochrome b5 + H2O
-
-
-
?
(8Z,11Z,14Z)-icosa-8,11,14-trienoyl-[glycerolipid] + ferrocytochrome b5 + O2 + H+
(5Z,8Z,11Z,14Z)-icosatetra-5,8,11,14-tetraenoyl-[glycerolipid] + ferricytochrome b5 + H2O
-
-
-
-
?
(8Z,11Z,14Z)-icosa-8,11,14-trienoyl-[glycerolipid] + ferrocytochrome b5 + O2 + H+
(5Z,8Z,11Z,14Z)-icosatetra-5,8,11,14-tetraenoyl-[glycerolipid] + ferricytochrome b5 + H2O
-
-
-
-
?
(8Z,11Z,14Z)-icosa-8,11,14-trienoyl-[glycerolipid] + ferrocytochrome b5 + O2 + H+
(5Z,8Z,11Z,14Z)-icosatetra-5,8,11,14-tetraenoyl-[glycerolipid] + ferricytochrome b5 + H2O
-
-
-
-
?
(8Z,11Z,14Z)-icosa-8,11,14-trienoyl-[glycerolipid] + ferrocytochrome b5 + O2 + H+
(5Z,8Z,11Z,14Z)-icosatetra-5,8,11,14-tetraenoyl-[glycerolipid] + ferricytochrome b5 + H2O
-
-
-
-
?
(8Z,11Z,14Z)-icosa-8,11,14-trienoyl-[glycerolipid] + ferrocytochrome b5 + O2 + H+
(5Z,8Z,11Z,14Z)-icosatetra-5,8,11,14-tetraenoyl-[glycerolipid] + ferricytochrome b5 + H2O
-
-
-
-
?
(8Z,11Z,14Z,17Z)-icosa-8,11,14,17-tetraenoyl-[glycerolipid] + ferrocytochrome b5 + O2 + H+
(5Z,8Z,11Z,14Z,17Z)-icosa-5,8,11,14,17-pentaenoyl-[glycerolipid] + ferricytochrome b5 + H2O
-
-
-
-
?
(8Z,11Z,14Z,17Z)-icosa-8,11,14,17-tetraenoyl-[glycerolipid] + ferrocytochrome b5 + O2 + H+
(5Z,8Z,11Z,14Z,17Z)-icosa-5,8,11,14,17-pentaenoyl-[glycerolipid] + ferricytochrome b5 + H2O
-
-
-
-
?
(8Z,11Z,14Z,17Z)-icosa-8,11,14,17-tetraenoyl-[glycerolipid] + ferrocytochrome b5 + O2 + H+
(5Z,8Z,11Z,14Z,17Z)-icosa-5,8,11,14,17-pentaenoyl-[glycerolipid] + ferricytochrome b5 + H2O
-
-
-
-
?
(8Z,11Z,14Z,17Z)-icosa-8,11,14,17-tetraenoyl-[glycerolipid] + ferrocytochrome b5 + O2 + H+
(5Z,8Z,11Z,14Z,17Z)-icosa-5,8,11,14,17-pentaenoyl-[glycerolipid] + ferricytochrome b5 + H2O
-
-
-
-
?
(8Z,11Z,14Z,17Z)-icosa-8,11,14,17-tetraenoyl-[glycerolipid] + ferrocytochrome b5 + O2 + H+
(5Z,8Z,11Z,14Z,17Z)-icosa-5,8,11,14,17-pentaenoyl-[glycerolipid] + ferricytochrome b5 + H2O
-
-
-
?
(8Z,11Z,14Z,17Z)-icosa-8,11,14,17-tetraenoyl-[glycerolipid] + ferrocytochrome b5 + O2 + H+
(5Z,8Z,11Z,14Z,17Z)-icosa-5,8,11,14,17-pentaenoyl-[glycerolipid] + ferricytochrome b5 + H2O
-
-
-
-
?
(8Z,11Z,14Z,17Z)-icosa-8,11,14,17-tetraenoyl-[glycerolipid] + ferrocytochrome b5 + O2 + H+
(5Z,8Z,11Z,14Z,17Z)-icosa-5,8,11,14,17-pentaenoyl-[glycerolipid] + ferricytochrome b5 + H2O
-
-
-
-
?
(8Z,11Z,14Z,17Z)-icosa-8,11,14,17-tetraenoyl-[glycerolipid] + ferrocytochrome b5 + O2 + H+
(5Z,8Z,11Z,14Z,17Z)-icosa-5,8,11,14,17-pentaenoyl-[glycerolipid] + ferricytochrome b5 + H2O
-
-
-
-
?
(8Z,11Z,14Z,17Z)-icosa-8,11,14,17-tetraenoyl-[glycerolipid] + ferrocytochrome b5 + O2 + H+
(5Z,8Z,11Z,14Z,17Z)-icosa-5,8,11,14,17-pentaenoyl-[glycerolipid] + ferricytochrome b5 + H2O
-
-
-
-
?
(8Z,11Z,14Z,17Z)-icosa-8,11,14,17-tetraenoyl-[glycerolipid] + ferrocytochrome b5 + O2 + H+
(5Z,8Z,11Z,14Z,17Z)-icosa-5,8,11,14,17-pentaenoyl-[glycerolipid] + ferricytochrome b5 + H2O
-
-
-
-
?
(8Z,11Z,14Z,17Z)-icosa-8,11,14,17-tetraenoyl-[glycerolipid] + ferrocytochrome b5 + O2 + H+
(5Z,8Z,11Z,14Z,17Z)-icosa-5,8,11,14,17-pentaenoyl-[glycerolipid] + ferricytochrome b5 + H2O
-
-
-
-
?
(8Z,11Z,14Z,17Z)-icosa-8,11,14,17-tetraenoyl-[glycerolipid] + ferrocytochrome b5 + O2 + H+
(5Z,8Z,11Z,14Z,17Z)-icosa-5,8,11,14,17-pentaenoyl-[glycerolipid] + ferricytochrome b5 + H2O
-
-
-
-
?
an (8Z,11Z,14Z)-icosa-8,11,14-trienoyl-[glycerolipid] + 2 ferrocytochrome b5 + O2 + 2 H+
a (5Z,8Z,11Z,14Z)-icosatetra-5,8,11,14-tetraenoyl-[glycerolipid] + ferricytochrome b5 + 2 H2O
-
-
-
?
an (8Z,11Z,14Z)-icosa-8,11,14-trienoyl-[glycerolipid] + 2 ferrocytochrome b5 + O2 + 2 H+
a (5Z,8Z,11Z,14Z)-icosatetra-5,8,11,14-tetraenoyl-[glycerolipid] + ferricytochrome b5 + 2 H2O
-
-
-
?
dihomo-gamma-linolenic acid + ferrocytochrome b5 + O2 + H+
arachidonic acid + ferricytochrome b5 + H2O
-
-
-
?
dihomo-gamma-linolenic acid + ferrocytochrome b5 + O2 + H+
arachidonic acid + ferricytochrome b5 + H2O
-
-
-
-
?
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
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Acute Coronary Syndrome
Relationships of Fatty Acids, Delta-5 Desaturase Activity, and Lipid Profiles in Men with Acute Coronary Syndrome.
Atherosclerosis
Effects of compound-326, a selective delta-5 desaturase inhibitor, in ApoE knockout mice with two different protocols for atherosclerosis development.
Breast Neoplasms
Growth inhibitory and anti-metastatic activity of epithelial cell adhesion molecule targeted three-way junctional delta-5-desaturase siRNA nanoparticle for breast cancer therapy.
Breast Neoplasms
Knockdown delta-5-desaturase in breast cancer cells that overexpress COX-2 results in inhibition of growth, migration and invasion via a dihomo-?-linolenic acid peroxidation dependent mechanism.
Carcinoma, Hepatocellular
Linoleate and linolenate desaturation by rat hepatoma cells.
Cardiovascular Diseases
Novel Heterocyclic Compounds as Delta-5-Desaturase Inhibitors for Treating Metabolic and Cardiovascular Diseases.
Colitis, Ulcerative
Modulation in delta 9, delta 6, and delta 5 fatty acid desaturase activity in the human intestinal CaCo-2 cell line.
Colonic Neoplasms
Dihomo-?-linolenic acid inhibits xenograft tumor growth in mice bearing shRNA-transfected HCA-7 cells targeting delta-5-desaturase.
Colonic Neoplasms
Inhibition of cancer migration and invasion by knocking down delta-5-desaturase in COX-2 overexpressed cancer cells.
Colonic Neoplasms
Knockdown delta-5-desaturase promotes the formation of a novel free radical byproduct from COX-catalyzed ?-6 peroxidation to induce apoptosis and sensitize pancreatic cancer cells to chemotherapy drugs.
Colonic Neoplasms
Knockdown of delta-5-desaturase promotes the anti-cancer activity of dihomo-?-linolenic acid and enhances the efficacy of chemotherapy in colon cancer cells expressing COX-2.
Colonic Neoplasms
Specific delivery of delta-5-desaturase siRNA via RNA nanoparticles supplemented with dihomo-?-linolenic acid for colon cancer suppression.
Coronary Artery Disease
Relationships of Fatty Acids, Delta-5 Desaturase Activity, and Lipid Profiles in Men with Acute Coronary Syndrome.
Dermatitis, Atopic
Erythrocyte and plasma fatty acid patterns in dogs with atopic dermatitis and healthy dogs in the same household.
Diabetes Mellitus
Effect of L-arginine-nitric oxide system on the metabolism of essential fatty acids in chemical-induced diabetes mellitus.
Diabetes Mellitus, Type 2
Desaturation function does not decline after menopause in human females.
Diabetes Mellitus, Type 2
Effect of L-arginine-nitric oxide system on the metabolism of essential fatty acids in chemical-induced diabetes mellitus.
Diabetes Mellitus, Type 2
Plasma polyunsaturated fatty acid profile and delta-5 desaturase activity are altered in patients with type 2 diabetes.
Diabetes Mellitus, Type 2
Response to comment on Imamura et al. Plasma polyunsaturated fatty acid profile and delta-5 desaturase activity are altered in patients with type 2 diabetes. Metabolism 2014;63(11):1432-8.
Diabetes Mellitus, Type 2
The effect of FADS2 gene rs174583 polymorphism on desaturase activities, fatty acid profile, insulin resistance, biochemical indices, and incidence of type 2 diabetes.
Diabetes, Gestational
Longitudinal circulating concentrations of long-chain polyunsaturated fatty acids in the third trimester of pregnancy in gestational diabetes.
Dyslipidemias
One-Carbon Metabolism and Lipid Metabolism in DOHaD.
Fibrosarcoma
Eicosadiynoic acid: a non-toxic inhibitor of multiple enzymatic steps in the production of icosanoids from arachidonic acid.
Heart Failure
Mechanisms involved in the differential reduction of omega-3 and omega-6 highly unsaturated fatty acids by structural heart disease resulting in "HUFA deficiency".
Hyperinsulinism
Long-term melatonin administration reduces hyperinsulinemia and improves the altered fatty-acid compositions in type 2 diabetic rats via the restoration of Delta-5 desaturase activity.
Hypertension
Effect of sucrose addition to drinking water, that induces hypertension in the rats, on liver microsomal Delta9 and Delta5-desaturase activities.
Hypertriglyceridemia
Long-term melatonin administration reduces hyperinsulinemia and improves the altered fatty-acid compositions in type 2 diabetic rats via the restoration of Delta-5 desaturase activity.
Hypertriglyceridemia
Palmitoleic and Dihomo-?-Linolenic Acids Are Positively Associated With Abdominal Obesity and Increased Metabolic Risk in Children.
Infections
Dual expression of transgenic delta-5 and delta-6 desaturase in tilapia alters gut microbiota and enhances resistance to Vibrio vulnificus infection.
Inflammatory Bowel Diseases
Modulation in delta 9, delta 6, and delta 5 fatty acid desaturase activity in the human intestinal CaCo-2 cell line.
Insulin Resistance
A Novel Selective Inhibitor of Delta-5 Desaturase Lowers Insulin Resistance and Reduces Body Weight in Diet-Induced Obese C57BL/6J Mice.
Insulin Resistance
Association of Changes in Body Fatness and Fatty Acid Composition of Plasma Phospholipids During Early Puberty in Japanese Children.
Insulin Resistance
Characteristics of obese children with low content of arachidonic acid in plasma lipids.
Insulin Resistance
Decreased Liver Fatty Acid Delta-6 and Delta-5 Desaturase Activity in Obese Patients.
Insulin Resistance
Dietary fat and insulin action in humans.
Insulin Resistance
Effects of fish oil alone and combined with long chain (n-6) fatty acids on some coronary risk factors in male subjects.
Insulin Resistance
Effects of Hypoxia and Bed Rest on Markers of Cardiometabolic Risk: Compensatory Changes in Circulating TRAIL and Glutathione Redox Capacity.
Insulin Resistance
Effects of two-months balanced diet in metabolically healthy obesity: lipid correlations with gender and BMI-related differences.
Insulin Resistance
Improvements in glucose tolerance and insulin sensitivity after lifestyle intervention are related to changes in serum fatty acid profile and desaturase activities: the SLIM study.
Insulin Resistance
Lower estimates of delta-5 desaturase and elongase activity are related to adverse profiles for several metabolic risk factors in young Japanese women.
Insulin Resistance
Palmitoleic and Dihomo-?-Linolenic Acids Are Positively Associated With Abdominal Obesity and Increased Metabolic Risk in Children.
Ketosis
Short-term diabetic ketosis alters n-6 polyunsaturated fatty acid content in plasma phospholipids.
Liver Cirrhosis
Advanced Liver Fibrosis Is Independently Associated with Palmitic Acid and Insulin Levels in Patients with Non-Alcoholic Fatty Liver Disease.
Lung Neoplasms
2D Nanomaterial, Ti3C2 MXene-Based Sensor to Guide Lung Cancer Therapy and Management.
Lung Neoplasms
Iminodibenzyl redirected cyclooxygenase-2 catalyzed dihomo-?-linolenic acid peroxidation pattern in lung cancer.
Malnutrition
One-Carbon Metabolism and Lipid Metabolism in DOHaD.
Metabolic Syndrome
Carrying minor allele of FADS1 and haplotype of FADS1 and FADS2 increased the risk of metabolic syndrome and moderate but not low fat diets lowered the risk in two Korean cohorts.
Metabolic Syndrome
Design, synthesis, and in vivo activity of novel inhibitors of delta-5 desaturase for the treatment of metabolic syndrome.
Metabolic Syndrome
Docosahexaenoic Acid Content in Plasma Phospholipids and Desaturase Indices in Obese Children.
Metabolic Syndrome
Omega-6 polyunsaturated fatty acids, serum zinc, delta-5- and delta-6-desaturase activities and incident metabolic syndrome.
Myocardial Infarction
The serum cholesterol ester fatty acid composition but not the serum concentration of alpha tocopherol predicts the development of myocardial infarction in 50-year-old men: 19 years follow-up.
Neoplasms
Delta-5-desaturase: A novel therapeutic target for cancer management.
Neoplasms
Dihomo-?-linolenic acid inhibits growth of xenograft tumors in mice bearing human pancreatic cancer cells (BxPC-3) transfected with delta-5-desaturase shRNA.
Neoplasms
Dihomo-?-linolenic acid inhibits xenograft tumor growth in mice bearing shRNA-transfected HCA-7 cells targeting delta-5-desaturase.
Neoplasms
EpCAM-Targeted 3WJ RNA Nanoparticle Harboring Delta-5-Desaturase siRNA Inhibited Lung Tumor Formation via DGLA Peroxidation.
Neoplasms
Erratum to "Inhibition of cancer migration and invasion by knocking down delta-5-desaturase in COX-2 overexpressed cancer cells" [Redox Biol. 11 (2017) 653-662].
Neoplasms
Iminodibenzyl induced redirected COX-2 activity inhibits breast cancer progression.
Neoplasms
Inhibition of cancer migration and invasion by knocking down delta-5-desaturase in COX-2 overexpressed cancer cells.
Neoplasms
Knockdown delta-5-desaturase in breast cancer cells that overexpress COX-2 results in inhibition of growth, migration and invasion via a dihomo-?-linolenic acid peroxidation dependent mechanism.
Neoplasms
Knockdown of delta-5-desaturase promotes the anti-cancer activity of dihomo-?-linolenic acid and enhances the efficacy of chemotherapy in colon cancer cells expressing COX-2.
Neoplasms
Prostate tumor growth can be modulated by dietarily targeting the 15-lipoxygenase-1 and cyclooxygenase-2 enzymes.
Neoplasms
Specific delivery of delta-5-desaturase siRNA via RNA nanoparticles supplemented with dihomo-?-linolenic acid for colon cancer suppression.
Neoplasms
The effect of chemical hepatocarcinogenesis on liver phospholipid composition in rats fed N-6 and N-3 fatty acid-supplemented diets.
Neoplasms
Tissue distribution and metabolism of gamma-linolenoyl-3-eicosapentaenoyl propane diol enterally or intravenously administered to mice bearing human pancreatic carcinomas.
Neuroblastoma
Differential effects of steroids on the synthesis of polyunsaturated fatty acids by human neuroblastoma cells.
Obesity
Dietary fats, membrane phospholipids and obesity.
Obesity, Abdominal
Abdominal adiposity is associated with fatty acid desaturase activity in boys: Implications for C-reactive protein and insulin resistance.
Overweight
Palmitoleic and Dihomo-?-Linolenic Acids Are Positively Associated With Abdominal Obesity and Increased Metabolic Risk in Children.
Pancreatic Neoplasms
Dihomo-?-linolenic acid inhibits growth of xenograft tumors in mice bearing human pancreatic cancer cells (BxPC-3) transfected with delta-5-desaturase shRNA.
Pancreatic Neoplasms
EpCAM-Targeted 3WJ RNA Nanoparticle Harboring Delta-5-Desaturase siRNA Inhibited Lung Tumor Formation via DGLA Peroxidation.
Pancreatic Neoplasms
Inhibition of cancer migration and invasion by knocking down delta-5-desaturase in COX-2 overexpressed cancer cells.
Pancreatic Neoplasms
Knockdown delta-5-desaturase promotes the formation of a novel free radical byproduct from COX-catalyzed ?-6 peroxidation to induce apoptosis and sensitize pancreatic cancer cells to chemotherapy drugs.
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Fujiwara, Y.; Okayasu, T.; Ishibashi, T.; Imai, Y.
Immunochemical evidence for the enzymatic difference of DELTA6-desaturase from DELTA9- and DELTA5-desaturase in rat liver microsomes
Biochem. Biophys. Res. Commun.
110
36-41
1983
Rattus norvegicus
brenda
Michaelson, L.V.; Lazarus, C.M.; Griffiths, G.; Napier, J.A.; Stobart, A.K.
Isolation of a DELTA5-fatty acid desaturase gene from Mortierella alpina
J. Biol. Chem.
273
19055-19059
1998
Mortierella alpina (O74212), Mortierella alpina, Mortierella alpina CBS 210.32 (O74212)
brenda
Kaewsuwan, S.; Cahoon, E.B.; Perroud, P.F.; Wiwat, C.; Panvisavas, N.; Quatrano, R.S.; Cove, D.J.; Bunyapraphatsara, N.
Identification and functional characterization of the moss Physcomitrella patens DELTA5-desaturase gene involved in arachidonic and eicosapentaenoic acid biosynthesis
J. Biol. Chem.
281
21988-21997
2006
Physcomitrium patens
brenda
Zhou, X.R.; Robert, S.S.; Petrie, J.R.; Frampton, D.M., Mansour, M.P.; Blackburn, S.I.; Nichols, P.D.; Green, A.G.; Singh, S.P.
Isolation and characterization of genes from the marine microalga Pavlova salina encoding three front-end desaturases involved in docosahexaenoic acid biosynthesis
Phytochemistry
68
785-796
2007
Rebecca salina (A4KDP0), Rebecca salina
brenda
Tavares, S.; Grotkjaer, T.; Obsen, T.; Haslam, R.; Napier, J.; Gunnarsson, N.
Metabolic engineering of Saccharomyces cerevisiae for production of eicosapentaenoic acid, using a novel DELTA5-desaturase from Paramecium tetraurelia
Appl. Environ. Microbiol.
77
1854-1861
2011
Leishmania major, Mortierella alpina, Paramecium tetraurelia, Ostreococcus tauri, Ostreococcus sp. 'lucimarinus'
brenda
Watts, J.; Browse, J.
Isolation and characterization of a DELTA5-fatty acid desaturase from Caenorhabditis elegans
Arch. Biochem. Biophys.
362
175-182
1999
Caenorhabditis elegans
brenda
Leikin, A.; Brenner, R.
In vivo phospholipid modification induces changes in microsomal DELTA5-desaturase activity
Biochim. Biophys. Acta
1165
189-193
1992
Rattus norvegicus
brenda
Baugh, S.; Pabba, P.; Barbosa, J.; Coulter, E.; Desai, U.; Gay, J.; Gopinathan, S.; Han, Q.; Hari, R.; Kimball, S.; Nguyen, H.; Ni, C.; Powell, D.; Smith, A.; Terranova, K.; Wilson, A.; Yu, X.; Lombardo, V.
Design, synthesis, and in vivo activity of novel inhibitors of delta-5 desaturase for the treatment of metabolic syndrome
Bioorg. Med. Chem. Lett.
25
3836-3839
2015
Mus musculus
brenda
Kumon, Y.; Kamisaka, Y.; Tomita, N.; Kimura, K.; Uemura, H.; Yokochi, T.; Yokoyama, R.; Honda, D.
Isolation and characterization of a DELTA5-desaturase from Oblongichytrium sp.
Biosci. Biotechnol. Biochem.
72
2224-2227
2008
Oblongichytrium sp. SEK 347 (B5MFC9)
brenda
Saito, T.; Ochiai, H.
Identification of DELTA5-fatty acid desaturase from the cellular slime mold Dictyostelium discoideum
Eur. J. Biochem.
265
809-814
1999
Dictyostelium discoideum, Dictyostelium discoideum AX2
brenda
Peng, K.; Zheng, C.; Xue, J.; Chen, X.; Yang, W.; Liu, J.; Bai, W.; Li, H.
Delta 5 fatty acid desaturase upregulates the synthesis of polyunsaturated fatty acids in the marine diatom Phaeodactylum tricornutum
J. Agric. Food Chem.
62
8773-8776
2014
Phaeodactylum tricornutum
brenda
Altabe, S.; Aguilar, P.; Caballero, G.; De Mendozal, D.
The Bacillus subtilis acyl lipid desaturase is a DELTA5 desaturase
J. Bacteriol.
185
3228-3231
2003
Bacillus subtilis, Bacillus subtilis JH642
brenda
Knutzon, D.; Thurmond, J.; Huang, Y.; Chaudhary, S.; Bobik Jr., E.; Chan, G.; Kirchner, S.; Mukerji, P.
Identification of DELTA5-desaturase from Mortierella alpina by heterologous expression in bakers yeast and canola
J. Biol. Chem.
273
29360-29366
1998
Mortierella alpina, Mortierella alpina ATCC 32221
brenda
Cho, H.; Nakamura, M.; Clarke, S.
Cloning, expression, and fatty acid regulation of the human DELTA-5 desaturase
J. Biol. Chem.
274
37335-37339
1999
Rattus norvegicus, Homo sapiens (Q9Y5Q0), Homo sapiens
brenda
Rodriguez, A.; Sarda, P.; Nessmann, C.; Boulot, P.; Leger, C.; Descomps, B.
DELTA6- and DELTA5-desaturase activities in the human fetal liver: Kinetic aspects
J. Lipid Res.
39
1825-1832
1998
Homo sapiens
brenda
Meesapyodsuk, D.; Qiu, X.
The front-end desaturase: Structure, function, evolution and biotechnological use
Lipids
47
227-237
2012
Mortierella alpina (O74212)
brenda
El Boustani, S.; Causse, J.; Descomps, B.; Monnier, L.; Mendy, F.; de Paulet, A.
Direct in vivo characterization of delta 5 desaturase activity in humans by deuterium labeling: Effect of insulin
Metab. Clin. Exp.
38
315-321
1989
Homo sapiens
brenda
Imamura, S.; Morioka, T.; Yamazaki, Y.; Numaguchi, R.; Urata, H.; Motoyama, K.; Mori, K.; Fukumoto, S.; Shoji, T.; Emoto, M.; Inaba, M.
Response to comment on Imamura et al. Plasma polyunsaturated fatty acid profile and delta-5 desaturase activity are altered in patients with type 2 diabetes
Metab. Clin. Exp.
63
1432-1438
2014
Homo sapiens
brenda
Saito, T.; Kato, A.; Ochiai, H.; Morita, N.
Temperature adaptation in Dictyostelium: Role of DELTA5 fatty acid desaturase
Microbiology
151
113-119
2005
Dictyostelium discoideum, Dictyostelium discoideum AX2
brenda
Irazu, C.; Gonzalez-Rodriguez, S.; Brenner, R.
DELTA5 Desaturase activity in rat kidney microsomes
Mol. Cell. Biochem.
129
31-37
1993
Rattus norvegicus
brenda
Shimizu, S.; Kawashima, H.; Akimoto, K.; Shinmen, Y.; Sugano, H.; Yamada, H.
Inhibition of DELTA5-desaturase in polyunsaturated fatty acid biosynthesis by (-)-asarinin and (-)-epiasarinin
Phytochemistry
31
757-760
1992
Rattus norvegicus
-
brenda
Sayanova, O.; Haslam, R.; Caleron, M.; Napier, J.
Cloning and characterization of unusual fatty acid desaturases from Anemone leveillei: Identification of an acyl-coenzyme A C20 DELTA5-desaturase responsible for the synthesis of sciadonic acid
Plant Physiol.
144
455-467
2007
Anemone leveillei
brenda
Gromovsky, A.D.; Schugar, R.C.; Brown, A.L.; Helsley, R.N.; Burrows, A.C.; Ferguson, D.; Zhang, R.; Sansbury, B.E.; Lee, R.G.; Morton, R.E.; Allende, D.S.; Parks, J.S.; Spite, M.; Brown, J.M.
DELTA-5 fatty acid desaturase FADS1 impacts metabolic disease by balancing proinflammatory and proresolving lipid mediators
Arterioscler. Thromb. Vasc. Biol.
38
218-231
2017
Homo sapiens (O60427)
brenda
Wang, Y.D.; Peng, K.C.; Wu, J.L.; Chen, J.Y.
Transgenic expression of salmon DELTA-5 and DELTA-6 desaturase in zebrafish muscle inhibits the growth of Vibrio alginolyticus and affects fish immunomodulatory activity
Fish Shellfish Immunol.
39
223-230
2014
Salmo salar (Q8QGE2)
brenda
Lopez-Vicario, C.; Gonzalez-Periz, A.; Rius, B.; Moran-Salvador, E.; Garcia-Alonso, V.; Lozano, J.; Bataller, R.; Cofan, M.; Kang, J.; Arroyo, V.; Claria, J.; Titos, E.
Molecular interplay between DELTA5/DELTA6 desaturases and long-chain fatty acids in the pathogenesis of non-alcoholic steatohepatitis
Gut
63
344-355
2014
Homo sapiens (O60427), Mus musculus (Q920L1)
brenda
Hagstroem, A.K.; Albre, J.; Tooman, L.K.; Thirmawithana, A.H.; Corcoran, J.; Loefstedt, C.; Newcomb, R.D.
A novel fatty acyl desaturase from the pheromone glands of Ctenopseustis obliquana and C. herana with specific Z5-desaturase activity on myristic acid
J. Chem. Ecol.
40
63-70
2014
Ctenopseustis obliquana (V5RE74), Ctenopseustis obliquana (V5REH3), Ctenopseustis obliquana, Ctenopseustis herana (V5RGA3), Ctenopseustis herana
brenda
Yary, T.; Voutilainen, S.; Tuomainen, T.P.; Ruusunen, A.; Nurmi, T.; Virtanen, J.K.
Omega-6 polyunsaturated fatty acids, serum zinc, delta-5- and delta-6-desaturase activities and incident metabolic syndrome
J. Hum. Nutr. Diet.
30
506-514
2017
Homo sapiens (O60427), Homo sapiens
brenda
Fujimoto, J.; Okamoto, R.; Noguchi, N.; Hara, R.; Masada, S.; Kawamoto, T.; Nagase, H.; Tamura, Y.O.; Imanishi, M.; Takagahara, S.; Kubo, K.; Tohyama, K.; Iida, K.; Andou, T.; Miyahisa, I.; Matsui, J.; Hayashi, R.; Maekawa, T.; Matsunaga, N.
Discovery of 3,5-diphenyl-4-methyl-1,3-oxazolidin-2-ones as novel, potent, and orally available DELTA-5 desaturase (D5D) inhibitors
J. Med. Chem.
60
8963-8981
2017
Rattus norvegicus, Homo sapiens (O60427), Mus musculus (Q920L1)
brenda
Akter, S.; Kurotani, K.; Sato, M.; Hayashi, T.; Kuwahara, K.; Matsushita, Y.; Nakagawa, T.; Konishi, M.; Honda, T.; Yamamoto, S.; Hayashi, T.; Noda, M.; Mizoue, T.
High serum phospholipid dihomo-gamma-linoleic acid concentration and low DELTA5-desaturase activity are associated with increased risk of type 2 diabetes among Japanese adults in the Hitachi Health Study
J. Nutr.
147
1558-1566
2017
Homo sapiens (O60427)
brenda
Liu, H.; Guo, Z.; Zheng, H.; Wang, S.; Wang, Y.; Liu, W.; Zhang, G.
Functional characterization of a DELTA5-like fatty acyl desaturase and its expression during early embryogenesis in the noble scallop Chlamys nobilis Reeve
Mol. Biol. Rep.
41
7437-7445
2014
Mimachlamys nobilis (A0A060IIA2)
brenda
Pickens, C.A.; Matsuo, K.H.; Fenton, J.I.
Relationship between body mass index, C-peptide, and Delta-5-desaturase enzyme activity estimates in adult males
PLoS ONE
11
e0149305
2016
Homo sapiens (O60427)
brenda
Abdul Hamid, N.K.; Carmona-Antonanzas, G.; Monroig, O.; Tocher, D.R.; Turchini, G.M.; Donald, J.A.
Isolation and functional characterisation of a fads2 in Rainbow Trout (Oncorhynchus mykiss) with DELTA5 desaturase activity
PLoS ONE
11
e0150770
2016
Oncorhynchus mykiss (V9ITC5), Oncorhynchus mykiss
brenda