Reference on EC 1.14.19.30 - acyl-lipid (8-3)-desaturase
Please use the Reference Search for a specific query.
Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
REF. 
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Fujiwara, Y.; Okayasu, T.; Ishibashi, T.; Imai, Y.
Immunochemical evidence for the enzymatic difference of DELTA6-desaturase from DELTA9- and DELTA5-desaturase in rat liver microsomes
Biochem. Biophys. Res. Commun.
110
36-41
1983
Rattus norvegicus
Michaelson, L.V.; Lazarus, C.M.; Griffiths, G.; Napier, J.A.; Stobart, A.K.
Isolation of a DELTA5-fatty acid desaturase gene from Mortierella alpina
J. Biol. Chem.
273
19055-19059
1998
Mortierella alpina (O74212), Mortierella alpina, Mortierella alpina CBS 210.32 (O74212)
Kaewsuwan, S.; Cahoon, E.B.; Perroud, P.F.; Wiwat, C.; Panvisavas, N.; Quatrano, R.S.; Cove, D.J.; Bunyapraphatsara, N.
Identification and functional characterization of the moss Physcomitrella patens DELTA5-desaturase gene involved in arachidonic and eicosapentaenoic acid biosynthesis
J. Biol. Chem.
281
21988-21997
2006
Physcomitrium patens
Zhou, X.R.; Robert, S.S.; Petrie, J.R.; Frampton, D.M., Mansour, M.P.; Blackburn, S.I.; Nichols, P.D.; Green, A.G.; Singh, S.P.
Isolation and characterization of genes from the marine microalga Pavlova salina encoding three front-end desaturases involved in docosahexaenoic acid biosynthesis
Phytochemistry
68
785-796
2007
Rebecca salina (A4KDP0), Rebecca salina
Tavares, S.; Grotkjaer, T.; Obsen, T.; Haslam, R.; Napier, J.; Gunnarsson, N.
Metabolic engineering of Saccharomyces cerevisiae for production of eicosapentaenoic acid, using a novel DELTA5-desaturase from Paramecium tetraurelia
Appl. Environ. Microbiol.
77
1854-1861
2011
Leishmania major, Mortierella alpina, Paramecium tetraurelia, Ostreococcus tauri, Ostreococcus sp. 'lucimarinus'
Watts, J.; Browse, J.
Isolation and characterization of a DELTA5-fatty acid desaturase from Caenorhabditis elegans
Arch. Biochem. Biophys.
362
175-182
1999
Caenorhabditis elegans
Leikin, A.; Brenner, R.
In vivo phospholipid modification induces changes in microsomal DELTA5-desaturase activity
Biochim. Biophys. Acta
1165
189-193
1992
Rattus norvegicus
Baugh, S.; Pabba, P.; Barbosa, J.; Coulter, E.; Desai, U.; Gay, J.; Gopinathan, S.; Han, Q.; Hari, R.; Kimball, S.; Nguyen, H.; Ni, C.; Powell, D.; Smith, A.; Terranova, K.; Wilson, A.; Yu, X.; Lombardo, V.
Design, synthesis, and in vivo activity of novel inhibitors of delta-5 desaturase for the treatment of metabolic syndrome
Bioorg. Med. Chem. Lett.
25
3836-3839
2015
Mus musculus
Kumon, Y.; Kamisaka, Y.; Tomita, N.; Kimura, K.; Uemura, H.; Yokochi, T.; Yokoyama, R.; Honda, D.
Isolation and characterization of a DELTA5-desaturase from Oblongichytrium sp.
Biosci. Biotechnol. Biochem.
72
2224-2227
2008
Oblongichytrium sp. SEK 347 (B5MFC9)
Saito, T.; Ochiai, H.
Identification of DELTA5-fatty acid desaturase from the cellular slime mold Dictyostelium discoideum
Eur. J. Biochem.
265
809-814
1999
Dictyostelium discoideum, Dictyostelium discoideum AX2
Peng, K.; Zheng, C.; Xue, J.; Chen, X.; Yang, W.; Liu, J.; Bai, W.; Li, H.
Delta 5 fatty acid desaturase upregulates the synthesis of polyunsaturated fatty acids in the marine diatom Phaeodactylum tricornutum
J. Agric. Food Chem.
62
8773-8776
2014
Phaeodactylum tricornutum
Altabe, S.; Aguilar, P.; Caballero, G.; De Mendozal, D.
The Bacillus subtilis acyl lipid desaturase is a DELTA5 desaturase
J. Bacteriol.
185
3228-3231
2003
Bacillus subtilis, Bacillus subtilis JH642
Knutzon, D.; Thurmond, J.; Huang, Y.; Chaudhary, S.; Bobik Jr., E.; Chan, G.; Kirchner, S.; Mukerji, P.
Identification of DELTA5-desaturase from Mortierella alpina by heterologous expression in bakers yeast and canola
J. Biol. Chem.
273
29360-29366
1998
Mortierella alpina, Mortierella alpina ATCC 32221
Cho, H.; Nakamura, M.; Clarke, S.
Cloning, expression, and fatty acid regulation of the human DELTA-5 desaturase
J. Biol. Chem.
274
37335-37339
1999
Rattus norvegicus, Homo sapiens (Q9Y5Q0), Homo sapiens
Rodriguez, A.; Sarda, P.; Nessmann, C.; Boulot, P.; Leger, C.; Descomps, B.
DELTA6- and DELTA5-desaturase activities in the human fetal liver: Kinetic aspects
J. Lipid Res.
39
1825-1832
1998
Homo sapiens
Meesapyodsuk, D.; Qiu, X.
The front-end desaturase: Structure, function, evolution and biotechnological use
Lipids
47
227-237
2012
Mortierella alpina (O74212)
El Boustani, S.; Causse, J.; Descomps, B.; Monnier, L.; Mendy, F.; de Paulet, A.
Direct in vivo characterization of delta 5 desaturase activity in humans by deuterium labeling: Effect of insulin
Metab. Clin. Exp.
38
315-321
1989
Homo sapiens
Imamura, S.; Morioka, T.; Yamazaki, Y.; Numaguchi, R.; Urata, H.; Motoyama, K.; Mori, K.; Fukumoto, S.; Shoji, T.; Emoto, M.; Inaba, M.
Response to comment on Imamura et al. Plasma polyunsaturated fatty acid profile and delta-5 desaturase activity are altered in patients with type 2 diabetes
Metab. Clin. Exp.
63
1432-1438
2014
Homo sapiens
Saito, T.; Kato, A.; Ochiai, H.; Morita, N.
Temperature adaptation in Dictyostelium: Role of DELTA5 fatty acid desaturase
Microbiology
151
113-119
2005
Dictyostelium discoideum, Dictyostelium discoideum AX2
Irazu, C.; Gonzalez-Rodriguez, S.; Brenner, R.
DELTA5 Desaturase activity in rat kidney microsomes
Mol. Cell. Biochem.
129
31-37
1993
Rattus norvegicus
Shimizu, S.; Kawashima, H.; Akimoto, K.; Shinmen, Y.; Sugano, H.; Yamada, H.
Inhibition of DELTA5-desaturase in polyunsaturated fatty acid biosynthesis by (-)-asarinin and (-)-epiasarinin
Phytochemistry
31
757-760
1992
Rattus norvegicus
-
Sayanova, O.; Haslam, R.; Caleron, M.; Napier, J.
Cloning and characterization of unusual fatty acid desaturases from Anemone leveillei: Identification of an acyl-coenzyme A C20 DELTA5-desaturase responsible for the synthesis of sciadonic acid
Plant Physiol.
144
455-467
2007
Anemone leveillei
Gromovsky, A.D.; Schugar, R.C.; Brown, A.L.; Helsley, R.N.; Burrows, A.C.; Ferguson, D.; Zhang, R.; Sansbury, B.E.; Lee, R.G.; Morton, R.E.; Allende, D.S.; Parks, J.S.; Spite, M.; Brown, J.M.
DELTA-5 fatty acid desaturase FADS1 impacts metabolic disease by balancing proinflammatory and proresolving lipid mediators
Arterioscler. Thromb. Vasc. Biol.
38
218-231
2017
Homo sapiens (O60427)
Wang, Y.D.; Peng, K.C.; Wu, J.L.; Chen, J.Y.
Transgenic expression of salmon DELTA-5 and DELTA-6 desaturase in zebrafish muscle inhibits the growth of Vibrio alginolyticus and affects fish immunomodulatory activity
Fish Shellfish Immunol.
39
223-230
2014
Salmo salar (Q8QGE2)
Lopez-Vicario, C.; Gonzalez-Periz, A.; Rius, B.; Moran-Salvador, E.; Garcia-Alonso, V.; Lozano, J.; Bataller, R.; Cofan, M.; Kang, J.; Arroyo, V.; Claria, J.; Titos, E.
Molecular interplay between DELTA5/DELTA6 desaturases and long-chain fatty acids in the pathogenesis of non-alcoholic steatohepatitis
Gut
63
344-355
2014
Homo sapiens (O60427), Mus musculus (Q920L1)
Hagstroem, A.K.; Albre, J.; Tooman, L.K.; Thirmawithana, A.H.; Corcoran, J.; Loefstedt, C.; Newcomb, R.D.
A novel fatty acyl desaturase from the pheromone glands of Ctenopseustis obliquana and C. herana with specific Z5-desaturase activity on myristic acid
J. Chem. Ecol.
40
63-70
2014
Ctenopseustis obliquana (V5RE74), Ctenopseustis obliquana (V5REH3), Ctenopseustis obliquana, Ctenopseustis herana (V5RGA3), Ctenopseustis herana
Yary, T.; Voutilainen, S.; Tuomainen, T.P.; Ruusunen, A.; Nurmi, T.; Virtanen, J.K.
Omega-6 polyunsaturated fatty acids, serum zinc, delta-5- and delta-6-desaturase activities and incident metabolic syndrome
J. Hum. Nutr. Diet.
30
506-514
2017
Homo sapiens (O60427), Homo sapiens
Fujimoto, J.; Okamoto, R.; Noguchi, N.; Hara, R.; Masada, S.; Kawamoto, T.; Nagase, H.; Tamura, Y.O.; Imanishi, M.; Takagahara, S.; Kubo, K.; Tohyama, K.; Iida, K.; Andou, T.; Miyahisa, I.; Matsui, J.; Hayashi, R.; Maekawa, T.; Matsunaga, N.
Discovery of 3,5-diphenyl-4-methyl-1,3-oxazolidin-2-ones as novel, potent, and orally available DELTA-5 desaturase (D5D) inhibitors
J. Med. Chem.
60
8963-8981
2017
Rattus norvegicus, Homo sapiens (O60427), Mus musculus (Q920L1)
Akter, S.; Kurotani, K.; Sato, M.; Hayashi, T.; Kuwahara, K.; Matsushita, Y.; Nakagawa, T.; Konishi, M.; Honda, T.; Yamamoto, S.; Hayashi, T.; Noda, M.; Mizoue, T.
High serum phospholipid dihomo-gamma-linoleic acid concentration and low DELTA5-desaturase activity are associated with increased risk of type 2 diabetes among Japanese adults in the Hitachi Health Study
J. Nutr.
147
1558-1566
2017
Homo sapiens (O60427)
Liu, H.; Guo, Z.; Zheng, H.; Wang, S.; Wang, Y.; Liu, W.; Zhang, G.
Functional characterization of a DELTA5-like fatty acyl desaturase and its expression during early embryogenesis in the noble scallop Chlamys nobilis Reeve
Mol. Biol. Rep.
41
7437-7445
2014
Mimachlamys nobilis (A0A060IIA2)
Pickens, C.A.; Matsuo, K.H.; Fenton, J.I.
Relationship between body mass index, C-peptide, and Delta-5-desaturase enzyme activity estimates in adult males
PLoS ONE
11
e0149305
2016
Homo sapiens (O60427)
Abdul Hamid, N.K.; Carmona-Antonanzas, G.; Monroig, O.; Tocher, D.R.; Turchini, G.M.; Donald, J.A.
Isolation and functional characterisation of a fads2 in Rainbow Trout (Oncorhynchus mykiss) with DELTA5 desaturase activity
PLoS ONE
11
e0150770
2016
Oncorhynchus mykiss (V9ITC5), Oncorhynchus mykiss
html completed
