Information on EC 1.2.1.33 - (R)-dehydropantoate dehydrogenase

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The enzyme appears in viruses and cellular organisms

EC NUMBER
COMMENTARY hide
1.2.1.33
-
RECOMMENDED NAME
GeneOntology No.
(R)-dehydropantoate dehydrogenase
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
(R)-4-dehydropantoate + NAD+ + H2O = (R)-3,3-dimethylmalate + NADH + 2 H+
show the reaction diagram
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-
-
-
REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
oxidation
-
-
-
-
redox reaction
-
-
-
-
reduction
-
-
-
-
PATHWAY
BRENDA Link
KEGG Link
MetaCyc Link
Pantothenate and CoA biosynthesis
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-
SYSTEMATIC NAME
IUBMB Comments
(R)-4-dehydropantoate:NAD+ 4-oxidoreductase
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CAS REGISTRY NUMBER
COMMENTARY hide
37250-96-7
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ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
P-2
-
-
Manually annotated by BRENDA team
P-2
-
-
Manually annotated by BRENDA team
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
(R)-4-dehydropantoate + NAD+
(R)-3,3-dimethylmalate + NADH
show the reaction diagram
(R)-4-dehydropantoate + NAD+ + H2O
(R)-3,3-dimethylmalate + NADH
show the reaction diagram
NATURAL SUBSTRATES
NATURAL PRODUCTS
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
(R)-4-dehydropantoate + NAD+
(R)-3,3-dimethylmalate + NADH
show the reaction diagram
COFACTOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
additional information
-
no diffusible cofactors found
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INHIBITORS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
(R)-4-Dehydropantoate
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-
NAD+
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above 0.3 mM
KM VALUE [mM]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.07
NAD+
-
-
SPECIFIC ACTIVITY [µmol/min/mg]
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
pH OPTIMUM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
9
-
or higher, activity increases from pH 7.0 to 9.5
pH RANGE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
7 - 9.5
-
activity increases from pH 7.0 to 9.5
TEMPERATURE STABILITY
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
50
-
4 min in presence of aldopantoate: no loss of activity, 1 min in absence of aldopantoate, complete loss of activity
GENERAL STABILITY
ORGANISM
UNIPROT
LITERATURE
aldopantoate stabilizes against heat
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STORAGE STABILITY
ORGANISM
UNIPROT
LITERATURE
0°C, 0.1 M potassium phosphate pH 7.5, 0.015 M mercaptoethanol, 3 days
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Purification/COMMENTARY
ORGANISM
UNIPROT
LITERATURE
P-2, partial
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