Information on EC 1.2.1.B25 - long-chain-fatty-acyl-CoA reductase

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The expected taxonomic range for this enzyme is: Arabidopsis thaliana

EC NUMBER
COMMENTARY hide
1.2.1.B25
preliminary BRENDA-supplied EC number
RECOMMENDED NAME
GeneOntology No.
long-chain-fatty-acyl-CoA reductase
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REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
hexadecanal + CoA + NADP+ = hexadecanoyl-CoA + NADPH
show the reaction diagram
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SYSTEMATIC NAME
IUBMB Comments
long-chain-aldehyde:NADP+ oxidoreductase
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ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
GENERAL INFORMATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
metabolism
enzyme is responsible for generating primary fatty alcohols associated with suberin biosynthesis; enzyme is responsible for generating primary fatty alcohols associated with suberin biosynthesis; enzyme is responsible for generating primary fatty alcohols associated with suberin biosynthesis
physiological function
observations reveal the association of the FAR6 gene with wound response
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
a long-chain fatty acyl-CoA + NADPH + H+
a long-chain aldehyde + CoA + NADP+
show the reaction diagram
additional information
?
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detailed analysis of FAR6 gene promotor
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?
SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE
; slight accumulation; slight accumulation
Manually annotated by BRENDA team
young; young and mature one; young and mature one
Manually annotated by BRENDA team
slight accumulation; slight accumulation
Manually annotated by BRENDA team
developing one; slight accumulation in developing ones; slight accumulation in developing ones
Manually annotated by BRENDA team
gene expressed predominantly
Manually annotated by BRENDA team
additional information
Cloned/COMMENTARY
ORGANISM
UNIPROT
LITERATURE
open reading frame subcloned into yeast expression vector pVT102U Saccharomyces cerevisiae; open reading frame subcloned into yeast expression vector pVT102U Saccharomyces cerevisiae; open reading frame subcloned into yeast expression vector pVT102U Saccharomyces cerevisiae
EXPRESSION
ORGANISM
UNIPROT
LITERATURE
expression is induced by wounding in the epidermal layer of mature stem internodes, transcript levels increase more than 2fold after 30 min of wounding
FAR1 transcript detectable by RT-PCR at 1 h after wounding and peaks at 48 h and remained high after 96 h, further induction after 4 h at salt concentrations of 50, 100, and 200 mM NaCl - FAR1 levels remain induced at 24 h only in the presence of 200 mM NaCl; FAR4 transcript detectable by RT-PCR at 24 h after wounding and peaks at 48 h and remained high after 96 h, further induction after 4 h at salt concentrations of 50, 100, and 200 mM NaCl - induced expression levels remain high after 24 h at all three salt concentrations; FAR5 transcript detectable by RT-PCR at 1 h after wounding and peaks at 48 h and remained high after 96 h, further induction after 4 h at salt concentrations of 50, 100, and 200 mM NaCl - induced expression levels remain high after 24 h at all three salt concentrations