Information on EC 1.2.3.5 - glyoxylate oxidase

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The enzyme appears in viruses and cellular organisms

EC NUMBER
COMMENTARY hide
1.2.3.5
-
RECOMMENDED NAME
GeneOntology No.
glyoxylate oxidase
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
glyoxylate + H2O + O2 = oxalate + H2O2
show the reaction diagram
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-
-
-
REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
oxidation
-
-
-
-
redox reaction
-
-
-
-
reduction
-
-
-
-
PATHWAY
BRENDA Link
KEGG Link
MetaCyc Link
Glyoxylate and dicarboxylate metabolism
-
-
Metabolic pathways
-
-
SYSTEMATIC NAME
IUBMB Comments
glyoxylate:oxygen oxidoreductase
-
CAS REGISTRY NUMBER
COMMENTARY hide
37251-03-9
-
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
Tyromyces palustris
-
-
-
Manually annotated by BRENDA team
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
glycolaldehyde + O2 + H2O
?
show the reaction diagram
Tyromyces palustris
-
-
-
-
?
glycolate + O2 + H2O
?
show the reaction diagram
Tyromyces palustris
-
-
-
-
?
glyoxylic acid + O2 + H2O
oxalate + H2O2
show the reaction diagram
NATURAL SUBSTRATES
NATURAL PRODUCTS
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
glyoxylic acid + O2 + H2O
oxalate + H2O2
show the reaction diagram
COFACTOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
additional information
-
INHIBITORS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
4,4-dihydroxy-1,3-benzene disulfonic acid disodium salt
Tyromyces palustris
-
2 mM concentration 17% inhibition
benzoquinone
Tyromyces palustris
-
0.01 mM concentration 100% inhibition
CuSO4
Tyromyces palustris
-
0.05 mM concentration 100% inhibition
fluoroacetate
Tyromyces palustris
-
2 mM concentration 22% inhibition
KCN
-
20 mM concentration 25% inhibition
oxalate
Tyromyces palustris
-
moderate inhibitor
p-chloromercuribenzoate
Tyromyces palustris
-
0.1 mM concentration 100% inhibition
succinate
-
glyoxylate oxidase activity is repressed 10.7fold in the presence of succinate; glyoxylate oxidase activity is repressed 4.8fold in the presence of succinate
ACTIVATING COMPOUND
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
potassium ferricyanide
Tyromyces palustris
-
1 mM concentration 158% activation
Sodium azide
-
20 mM concentration 60% activation
KM VALUE [mM]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
3.7
glyoxylate
Tyromyces palustris
-
-
Ki VALUE [mM]
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.05
oxalate
Tyromyces palustris
-
-
pH OPTIMUM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
8
Tyromyces palustris
-
-
pH RANGE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
6.5 - 8.5
Tyromyces palustris
-
at pH 6.5 and 8.5 50% activity
TEMPERATURE OPTIMUM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
40
Tyromyces palustris
-
-
MOLECULAR WEIGHT
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
127000
Tyromyces palustris
-
gel filtration
Purification/COMMENTARY
ORGANISM
UNIPROT
LITERATURE